DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG44153 and Dscam4

DIOPT Version :9

Sequence 1:	NP_001097136.2	Gene:	CG44153 / 34341	FlyBaseID:	FBgn0265002	Length:	1946	Species:	Drosophila melanogaster
Sequence 2:	NP_001261571.1	Gene:	Dscam4 / 2769008	FlyBaseID:	FBgn0263219	Length:	1935	Species:	Drosophila melanogaster

Alignment Length:	1298	Identity:	244/1298 - (18%)
Similarity:	409/1298 - (31%)	Gaps:	440/1298 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   292 RCEIPEINETTQGCTSNSSSIECHQACDFDNFGR-SISPPGQSYSASKGNRNAARSGKTRYEVTM 355
            :|::|.........|:.......|...:.|..|: ::...|:.|..:.|..:|.:|      .|.
  Fly   147 KCQVPSYMSEFVLVTAWVQDTGMHLYPNTDIGGKYTVLSNGELYINNAGPNDAYKS------YTC 205

  Fly   356 RLGANLTGYYRHADREQLSG-----VMERQLGRVLRNFNITKISDLELISNSTDRLDI------- 408
            |....|||      ..|:|.     ::....|.|....|:.|.|...::.|....|..
  Fly   206 RTVNRLTG------EVQISTYPGRIIVTEPKGMVQPRINVEKHSMRHVVLNGQTTLPCIAQGHPV 264

  Fly   409 -TFHFFGVKGD-------SQRIR--DAITRMVERGRI---GNFTLVANFHHFDENPPLGL---LE 457
             |:.:|..:.:       |:||.  .|....:.:.|:   |.:....|....:|...:.|   ..
  Fly   265 PTYRWFKEENEQLLPLQLSERITIVSAGLLKITKARLEDSGKYLCWVNNTAGEETIQVSLTVTAP 329

  Fly   458 LTVN-QPQ---SGVREASEFIISCTAQGSSRMQFQWFKDGAVVNASKSTREIWTTVLPPETKDVY 518
            ||.: |||   ..|.:.::|  .|...|.......|..||..:...... ||.|.  ||.
  Fly   330 LTAHLQPQVQTVDVDKDAQF--QCIVSGHPVHDVNWLHDGKPILRDNRV-EILTD--PPR----- 384

  Fly   519 TAILGVTKASRIDEGVYSCKVT-DWGVEQCRSLHIHIKSPPRLRVDPAS---------VTLQRGD 573
               |.:.|..:.|.|:|.|.|: :|  ||       |:|...|::..||         .|||.|.
  Fly   385 ---LIIKKVQKEDPGMYQCFVSNEW--EQ-------IQSTAELQLGDASPELLYWFSEQTLQPGP 437

  Fly   574 SLRVRCLSPGNDDIKRYAQLGYSWTRNG--VLFQSDAATAMWEDLYPDG-SILKINNIQK--SAE 633
            ::.::|::.||...:      ::|:.:|  :...|......:..::.|. |.:.|:|:::  ..|
  Fly   438 TVSLKCVATGNPLPQ------FTWSLDGFPIPDSSRFLVGQYVTIHDDVISHVNISNVKEEDGGE 496

  Fly   634 YACLVSNSVRPVSRSVYINVIERNAVHVCPAESTYGVHWPTSAP------GSPIITDCP-RGF-- 689
            |.|...|::..||.|..:|:              ||:.:....|      ||.:|..|| .|:
  Fly   497 YTCTAQNAIGKVSHSAKVNI--------------YGLPYIREMPKITGISGSDLIVKCPVAGYPI 547

  Fly   690 -EGHLKRICE-------QRDTGNSTWLLPDFSGCVRDELLLIYNRFLALSAGFQ-QTNSSNILKA 745
             :.|.:|..:       ||...|.|.::...      :.|.....:..::...| ||:..|:
  Fly   548 DKIHWERDGQTLPINRRQRAYNNGTLIIEQL------QRLEDAGTYTCMAQNKQKQTSRRNV--- 603

  Fly   746 CFEFTLQRRHSFLPGEASFLIDMLHELDTYLQLKGTQLEREMAAEIILRILD-------KVMQNA 803
              |..:......:|.:|  :.:||.|              .|.|.|..:||:       :..:|.
  Fly   604 --EIQVLVPPKIMPIQA--MTNMLRE--------------GMRAAISCQILEGDLPVSFRWERNG 650

  Fly   804 QSL--NSQQQIKKLQQLTQSAALNRETIAASQ------LATSTSGSSQ---PL-----------P 846
            :.|  ...:..::|.:  .||:|..|.|::..      :|::.:|:.:   ||           |
  Fly   651 KPLIGTGNEVFRRLDE--YSASLVIEHISSDHSGNYTCIASNVAGTERFTVPLTVNVPPKWILEP 713

  Fly   847 GDSSTRGDDGSGSGVTAG-EMSAAPAGSLQATRAGGAGGGPGGASSILTVDEDTLSLDRLNSLRI 910
            .|||.:    :|:.|... :.|..|..::...:|  .|..||.....|
  Fly   714 KDSSAQ----AGADVLLHCQSSGYPTPTITWKKA--IGPTPGEYKDFL----------------- 755

  Fly   911 YMTSVKTLPFNLRIYGEDLFSDQLYMDIGLSSRLLHIMANSTIFASVISYKNLKSFLPKTYYTRG 975
            |..:|:..|                              |.|||...||.::...||.:.....|
  Fly   756 YEPTVQLFP------------------------------NGTIFFKKISKESQGHFLCEAKNNIG 790

  Fly   976 SDPRDSDYVLASRII----------QTWL------------FQSNRSNDNFREPLDLPFEAGHVE 1018
            |.        .|::|          ||..            .|.|...||   |:|..::   ::
  Fly   791 SG--------VSKVIFLKVNVPAHFQTKTKQISVAKGKQVHVQCNVQGDN---PIDFKWK---IQ 841

  Fly  1019 IIFQH--ESVPKK---GDWVAVCGHDYKASFDSTWRSDLCITKHLMANITRCICPLSGTY----- 1073
            ...|:  ||:..:   .|.|...|...:.....|:|.|..|          .||..|..:
  Fly   842 ATQQYLDESLDSRYTIRDQVLDDGMVSELGISHTYRQDTGI----------YICQASNAFGQDEM 896

  Fly  1074 ----VVMLTKRQPNATPHNAPRRPIFVIASCACCLLQCGSALLILVPIWCNRKCAVTFLKMQFCV 1134
                :|.....||.....|:.:
  Fly   897 SIQLIVQEVPEQPKNLRINSQQ------------------------------------------- 918

  Fly  1135 STSSVMLIYLLGFMKMLPVSWHGIISSSLAS-------LLLLGISTLIAIALAIHTELMPKKYLQ 1192
             :.|:.|.:...|....|:..:.|....::.       |.:.|..|:|.|     .:|.|.|...
  Fly   919 -SRSLQLTWSQPFAGNSPIEEYHIYYKQISDIWQNAEHLTIAGAQTVINI-----QQLRPAKAYH 977

  Fly  1193 IGSKPATPTKRRLRREQERERERERDRDRERDRELDSLSNITQIRAQSPLGATTASTTITTTTSS 1257
            |                                         ::.|::.|||:..|..:..||..
  Fly   978 I-----------------------------------------RMSAENKLGASEFSEVVQVTTLE 1001

  Fly  1258 SNP-----GQRRPPPSSTAGMRGAIGISWLLPLLFAVAAPLICSIIGQWPRHWWLEVL---WTG- 1313
            ..|     ..|..|.|||     .|.::|..|                 .|..|..:|   :.|
  Fly  1002 EVPSGPPLAVRAEPKSST-----EIFVTWDAP-----------------ERDHWNGILLGYYVGY 1044

  Fly  1314 --SASPEAGAGKDEAGDSDSGAF--YSAHSLLNGDNLL------------LESEAVMGNGTSSPP 1362
              |.:||    ..|...:...:|  ....|...|:.:|            :::....|:|..|..
  Fly  1045 QMSLTPE----DKEVNPTQGFSFKTVEVRSHFGGETVLANLNKFTQYHVIVQAYTSQGSGPPSKE 1105

  Fly  1363 TETSSASSSSSSTGRAVDDDVATSTSSITSIGSASNSGFSASWSGITSFSTSTSTTSSTSTSV 1425
            ....:.....||...:...||..|||...:.......|.:....|...|..|......|...|
  Fly  1106 IAVQTMEDVPSSPPESPQCDVLGSTSIYITWSPPDIDGQNGKIKGYKVFYISVDELYETDPEV 1168

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG44153	NP_001097136.2	EGF_CA	<264..294	CDD:238011	0/1 (0%)
		IG_like	467..554	CDD:214653	22/87 (25%)
		Ig	474..551	CDD:143165	20/77 (26%)
		IG_like	564..653	CDD:214653	23/102 (23%)
		Ig	572..642	CDD:299845	15/74 (20%)
		HRM	661..718	CDD:280888	15/73 (21%)
Dscam4	NP_001261571.1	Ig	31..124	CDD:416386
		Ig strand A	32..35	CDD:409353
		Ig strand A'	41..45	CDD:409353
		Ig strand B	48..57	CDD:409353
		Ig strand D	75..78	CDD:409353
		Ig strand E	83..88	CDD:409353
		Ig strand F	101..109	CDD:409353
		Ig strand G	112..124	CDD:409353
		Ig	235..326	CDD:416386	16/90 (18%)
		Ig strand A	235..238	CDD:409353	0/2 (0%)
		Ig strand A'	244..248	CDD:409353	0/3 (0%)
		Ig strand B	251..258	CDD:409353	1/6 (17%)
		Ig strand C	266..271	CDD:409353	1/4 (25%)
		Ig strand C'	276..279	CDD:409353	0/2 (0%)
		Ig strand D	285..289	CDD:409353	2/3 (67%)
		Ig strand E	292..298	CDD:409353	0/5 (0%)
		Ig strand F	305..313	CDD:409353	1/7 (14%)
		Ig strand G	316..326	CDD:409353	2/9 (22%)
		IgC2_3_Dscam	329..417	CDD:409549	30/109 (28%)
		Ig strand B	347..351	CDD:409549	1/5 (20%)
		Ig strand C	360..364	CDD:409549	0/3 (0%)
		Ig strand E	383..387	CDD:409549	2/11 (18%)
		Ig strand F	397..402	CDD:409549	2/4 (50%)
		Ig strand G	410..413	CDD:409549	1/2 (50%)
		IgI_4_Dscam	422..516	CDD:409548	21/99 (21%)
		Ig strand B	439..443	CDD:409548	0/3 (0%)
		Ig strand C	452..456	CDD:409548	0/9 (0%)
		Ig strand E	482..486	CDD:409548	1/3 (33%)
		Ig strand F	496..501	CDD:409548	3/4 (75%)
		Ig strand G	509..512	CDD:409548	1/2 (50%)
		IgI_5_Dscam	520..607	CDD:409550	19/97 (20%)
		Ig strand B	536..540	CDD:409550	1/3 (33%)
		Ig strand C	549..553	CDD:409550	1/3 (33%)
		Ig strand E	571..575	CDD:409550	1/3 (33%)
		Ig strand F	586..591	CDD:409550	0/4 (0%)
		Ig strand G	600..603	CDD:409550	0/2 (0%)
		Ig	610..703	CDD:416386	22/110 (20%)
		Ig strand A	611..613	CDD:409353	0/1 (0%)
		Ig strand A'	620..624	CDD:409353	1/3 (33%)
		Ig strand B	627..636	CDD:409353	3/8 (38%)
		Ig strand C	641..648	CDD:409353	0/6 (0%)
		Ig strand C'	650..652	CDD:409353	0/1 (0%)
		Ig strand D	659..664	CDD:409353	0/4 (0%)
		Ig strand E	668..675	CDD:409353	3/6 (50%)
		Ig strand F	682..690	CDD:409353	1/7 (14%)
		Ig strand G	693..702	CDD:409353	2/8 (25%)
		IgI_7_Dscam	706..801	CDD:409546	28/155 (18%)
		Ig strand B	724..728	CDD:409546	1/3 (33%)
		Ig strand C	737..741	CDD:409546	0/3 (0%)
		Ig strand E	766..770	CDD:409546	2/3 (67%)
		Ig strand F	780..785	CDD:409546	2/4 (50%)
		Ig strand G	794..797	CDD:409546	1/2 (50%)
		Ig	818..904	CDD:416386	20/101 (20%)
		putative Ig strand B	820..827	CDD:409353	1/6 (17%)
		putative Ig strand C	835..841	CDD:409353	1/8 (13%)
		putative Ig strand C'	853..856	CDD:409353	0/2 (0%)
		putative Ig strand D	862..866	CDD:409353	0/3 (0%)
		putative Ig strand E	868..874	CDD:409353	0/5 (0%)
		putative Ig strand F	881..889	CDD:409353	3/17 (18%)
		putative Ig strand G	892..902	CDD:409353	0/9 (0%)
		FN3	906..999	CDD:238020	22/182 (12%)
		FN3	1006..1110	CDD:238020	23/129 (18%)
		fn3	1117..1203	CDD:394996	12/52 (23%)
		FN3	1215..1307	CDD:238020
Ig	<1334..1401	CDD:416386
Ig strand C	1345..1349	CDD:409353
Ig strand D	1363..1366	CDD:409353
Ig strand E	1367..1372	CDD:409353
Ig strand F	1380..1388	CDD:409353
Ig strand G	1394..1401	CDD:409353
FN3	1405..1494	CDD:238020
FN3	1499..1580	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10075
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100