Protein Alignment IFIT1 and Utx

DIOPT Version :10

• Sequence 1: NP_001539.3
• Gene: IFIT1 / 3434
• HGNCID: 5407
• Length: 478
• Species: Homo sapiens
• Sequence 2: NP_609368.3
• Gene: Utx / 34377
• FlyBaseID: FBgn0260749
• Length: 1136
• Species: Drosophila melanogaster
• Alignment Length: 538
• Identity: 100/538 - (18%)
• Similarity: 185/538 - (34%)
• Gaps: 176/538 - (32%)

Human     4 NGDDHQVKDSLEQLRCHFTWELSIDDDEMPDLENRVLDQIEFLDTKYSVGIHNLLAYVKHLKGQN 68
            ||..|:.|:|                     .:|:  :.|:..:.....|.|     :::...:|
  Fly    50 NGQVHESKNS---------------------SDNK--NAIQKFEPSTQAGEH-----MENTSSRN 86

Human    69 EEALK----SLKEAENLMQEEHDNQANVRSLVTWGNFAWMYYHMGRLAEA----QTYLDKVENIC 125
            .:..|    ..||..::::|:|.::..|.:|...|:   ::..:|..:||    |.||...|| .
  Fly    87 NDDTKPFEQDAKEKVSIIEEKHQDEHYVNALCKLGH---LHLLLGEYSEALSAYQKYLRFREN-N 147

Human   126 KKLSNPFRYRMECPEIDCEEGWALLKCGGKNYERAKACFEKVLEVDPE---NPESSAGYAISAYR 187
            ...::.|.|.:..       .:..|:|    ::.|...|:::|.:.|.   ..|......:....
  Fly   148 YWTNHAFIYGIGV-------AYFKLRC----FKWAIKSFQELLYLSPNFTCANEVHLRLGLMLKH 201

Human   188 LDGFKLATKN---------HKPFSLLPLRQAVRLNPDNGYIKVLLALKLQDEGQEAEG--EKYIE 241
            ...|.:|.|:         ...||.|.::           .::....::|::.:.|:.  |..:.
  Fly   202 CGEFHIALKHLQLALLYTYPSTFSELQVK-----------FQIAHLYEVQNKHKAAKDGYEFLLN 255

Human   242 EALANMSSQTYVFRYAAKFY-------RRKGSVDKALELLKKALQETPTSVLLHHQIGLCYKAQM 299
            |...::..:..|:|.....|       .:|.....||..|:|:::..|.|....:.:|.||
  Fly   256 EKNISLELKADVYRQLGWMYHCVECLGEKKEREANALNFLQKSIEADPKSGQSLYLLGRCY---- 316

Human   300 IQIKEATKGQPRGQNREKLDKMIRSAIFHFESAVEK-------------------KPTFEVAHLD 345
                       .|.|:      :..|...:.::|||                   :||      |
  Fly   317 -----------AGINK------VHDAFLAYRNSVEKSEGNADTWCSIGVLYQQQNQPT------D 358

Human   346 LARMYIEA----GNHRKAEENFQKLLCMKPVVEETMQDIHFHYGRFQEFQKKSDVNAIIHYLKAI 406
            ..:.||.|    .:|:.|..|.       .::.|:...:...|..:        :||    .|.|
  Fly   359 ALQAYICAVQLDKDHKAAWTNL-------GILYESCGQLRDAYACY--------LNA----TKQI 404

Human   407 KIEQASLTRDKSINSLKKLVLRKLRRKALDLESLS--LLGFVYKLEGNMNEA-----------LE 458
            ..:::||.|.|....:||           |...||  |...:..|||.:::|           |.
  Fly   405 SFQKSSLIRKKQAIRMKK-----------DTIGLSKGLSQRITFLEGQLSQAPLPSITSKRRQLC 458

Human   459 YYERALRLAADFENSVRQ 476
            ..|.|..|....|.:.||
  Fly   459 SIEEAWNLPISLEMNSRQ 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IFIT1	NP_001539.3	TPR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	52..85		6/36 (17%)
		TPR repeat	54..80	CDD:276809	5/29 (17%)
		TPR	55..>245	CDD:440225	37/211 (18%)
		TPR 2. /evidence=ECO:0000255	95..128		10/36 (28%)
		TPR repeat	97..123	CDD:276809	7/29 (24%)
		TPR repeat	128..170	CDD:276809	7/41 (17%)
		TPR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	141..174		6/35 (17%)
		LapB	156..465	CDD:442196	66/365 (18%)
		TPR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	183..216		6/41 (15%)
		TPR repeat	216..246	CDD:276809	4/31 (13%)
		TPR 5. /evidence=ECO:0000255	218..249		4/32 (13%)
		TPR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	251..284		9/39 (23%)
		TPR repeat	252..279	CDD:276809	8/33 (24%)
		TPR repeat	284..335	CDD:276809	8/50 (16%)
		TPR 7. /evidence=ECO:0000255	305..339		7/52 (13%)
		TPR 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	340..373		7/36 (19%)
		TPR repeat	340..367	CDD:276809	7/30 (23%)
		TPR 9. /evidence=ECO:0000255	378..412		5/33 (15%)
		TPR repeat	378..407	CDD:276809	4/28 (14%)
		TPR 10. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	437..470		11/45 (24%)
		TPR repeat	437..465	CDD:276809	10/40 (25%)
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809	7/44 (16%)
		LapB	171..444	CDD:442196	62/340 (18%)
		TPR repeat	186..216	CDD:276809	4/29 (14%)
		TPR repeat	228..255	CDD:276809	3/37 (8%)
		TPR repeat	265..300	CDD:276809	8/34 (24%)
		TPR repeat	307..334	CDD:276809	6/47 (13%)
		TPR repeat	339..369	CDD:276809	6/35 (17%)
		TPR repeat	374..402	CDD:276809	6/46 (13%)
		JmjC	870..978	CDD:396791