DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IFIT1 and Utx

DIOPT Version :9

Sequence 1:	NP_001257856.1	Gene:	IFIT1 / 3434	HGNCID:	5407	Length:	478	Species:	Homo sapiens
Sequence 2:	NP_609368.3	Gene:	Utx / 34377	FlyBaseID:	FBgn0260749	Length:	1136	Species:	Drosophila melanogaster

Alignment Length:	538	Identity:	100/538 - (18%)
Similarity:	185/538 - (34%)	Gaps:	176/538 - (32%)

- Green bases have known domain annotations that are detailed below.

Human     4 NGDDHQVKDSLEQLRCHFTWELSIDDDEMPDLENRVLDQIEFLDTKYSVGIHNLLAYVKHLKGQN 68
            ||..|:.|:|                     .:|:  :.|:..:.....|.|     :::...:|
  Fly    50 NGQVHESKNS---------------------SDNK--NAIQKFEPSTQAGEH-----MENTSSRN 86

Human    69 EEALK----SLKEAENLMQEEHDNQANVRSLVTWGNFAWMYYHMGRLAEA----QTYLDKVENIC 125
            .:..|    ..||..::::|:|.::..|.:|...|:   ::..:|..:||    |.||...|| .
  Fly    87 NDDTKPFEQDAKEKVSIIEEKHQDEHYVNALCKLGH---LHLLLGEYSEALSAYQKYLRFREN-N 147

Human   126 KKLSNPFRYRMECPEIDCEEGWALLKCGGKNYERAKACFEKVLEVDPE---NPESSAGYAISAYR 187
            ...::.|.|.:..       .:..|:|    ::.|...|:::|.:.|.   ..|......:....
  Fly   148 YWTNHAFIYGIGV-------AYFKLRC----FKWAIKSFQELLYLSPNFTCANEVHLRLGLMLKH 201

Human   188 LDGFKLATKN---------HKPFSLLPLRQAVRLNPDNGYIKVLLALKLQDEGQEAEG--EKYIE 241
            ...|.:|.|:         ...||.|.::           .::....::|::.:.|:.  |..:.
  Fly   202 CGEFHIALKHLQLALLYTYPSTFSELQVK-----------FQIAHLYEVQNKHKAAKDGYEFLLN 255

Human   242 EALANMSSQTYVFRYAAKFY-------RRKGSVDKALELLKKALQETPTSVLLHHQIGLCYKAQM 299
            |...::..:..|:|.....|       .:|.....||..|:|:::..|.|....:.:|.||
  Fly   256 EKNISLELKADVYRQLGWMYHCVECLGEKKEREANALNFLQKSIEADPKSGQSLYLLGRCY---- 316

Human   300 IQIKEATKGQPRGQNREKLDKMIRSAIFHFESAVEK-------------------KPTFEVAHLD 345
                       .|.|:      :..|...:.::|||                   :||      |
  Fly   317 -----------AGINK------VHDAFLAYRNSVEKSEGNADTWCSIGVLYQQQNQPT------D 358

Human   346 LARMYIEA----GNHRKAEENFQKLLCMKPVVEETMQDIHFHYGRFQEFQKKSDVNAIIHYLKAI 406
            ..:.||.|    .:|:.|..|.       .::.|:...:...|..:        :||    .|.|
  Fly   359 ALQAYICAVQLDKDHKAAWTNL-------GILYESCGQLRDAYACY--------LNA----TKQI 404

Human   407 KIEQASLTRDKSINSLKKLVLRKLRRKALDLESLS--LLGFVYKLEGNMNEA-----------LE 458
            ..:::||.|.|....:||           |...||  |...:..|||.:::|           |.
  Fly   405 SFQKSSLIRKKQAIRMKK-----------DTIGLSKGLSQRITFLEGQLSQAPLPSITSKRRQLC 458

Human   459 YYERALRLAADFENSVRQ 476
            ..|.|..|....|.:.||
  Fly   459 SIEEAWNLPISLEMNSRQ 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IFIT1	NP_001257856.1	TPR 1	52..85		6/36 (17%)
		TPR_12	54..127	CDD:290160	18/80 (23%)
		TPR repeat	54..80	CDD:276809	5/29 (17%)
		TPR 2	95..128		10/36 (28%)
		TPR repeat	97..123	CDD:276809	7/29 (24%)
		TPR repeat	128..170	CDD:276809	7/41 (17%)
		TPR 3	139..174		6/37 (16%)
		TPR 4	183..216		6/41 (15%)
		TPR repeat	216..246	CDD:276809	4/31 (13%)
		TPR 5	218..249		4/32 (13%)
		TPR 6	251..284		9/39 (23%)
		TPR repeat	252..279	CDD:276809	8/33 (24%)
		Interaction with the 5'-triphosphate group of PPP-RNA. /evidence=ECO:0000250	256..262		1/12 (8%)
		TPR repeat	284..335	CDD:276809	8/50 (16%)
		TPR 7	305..339		7/52 (13%)
		TPR 8	340..373		7/36 (19%)
		TPR repeat	340..367	CDD:276809	7/30 (23%)
		TPR 9	378..412		5/33 (15%)
		TPR repeat	378..407	CDD:276809	4/28 (14%)
		TPR 10	437..470		11/45 (24%)
		TPR repeat	437..465	CDD:276809	10/40 (25%)
		TPR_1	438..470	CDD:278916	11/44 (25%)
Utx	NP_609368.3	TPR repeat	147..181	CDD:276809	7/44 (16%)
		TPR_11	156..216	CDD:290150	11/70 (16%)
		TPR repeat	186..216	CDD:276809	4/29 (14%)
		TPR repeat	228..255	CDD:276809	3/37 (8%)
		TPR_11	264..337	CDD:290150	19/93 (20%)
		TPR repeat	265..300	CDD:276809	8/34 (24%)
		TPR repeat	307..334	CDD:276809	6/47 (13%)
		TPR_11	339..402	CDD:290150	13/87 (15%)
		TPR repeat	339..369	CDD:276809	6/35 (17%)
		TPR_1	340..373	CDD:278916	6/38 (16%)
		TPR repeat	374..402	CDD:276809	6/46 (13%)
		JmjC	870..978	CDD:202224
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900