DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn31A and Serpind1

DIOPT Version :9

Sequence 1:	NP_609341.1	Gene:	Spn31A / 34339	FlyBaseID:	FBgn0032178	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_077358.1	Gene:	Serpind1 / 79224	RGDID:	619854	Length:	479	Species:	Rattus norvegicus

Alignment Length:	379	Identity:	89/379 - (23%)
Similarity:	158/379 - (41%)	Gaps:	52/379 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 ATSFAEQNVVVSPLLLEATLSLLFLGSDGATAEELQKQLRLKQRFASNAKMANFYAAELGNITTD 87
            |||  ..|:.::|:.:...:.::.||..|.|.||:...|..|....:::|.         .:||.
  Rat   125 ATS--SDNIFIAPVGISTAMGMISLGLRGETHEEVHSVLHFKDFVNASSKY---------EVTTI 178

  Fly    88 ADTF---------------LQLQNRLMLSSESGVADDFQKIAQTYFHATAECVDLEQ---TEKLR 134
            .:.|               ||..|.|.:..:..:.:||:...:.::.|.|:..|...   ..|..
  Rat   179 HNLFRKLTHRLFRRNFGYTLQSVNDLYIQKQFPIREDFKAAMREFYFAEAQEADFSDPAFISKAN 243

  Fly   135 RHISEQILASVGGGSWKDIHVAGGSSANTLLLLLAANLQSKWFLPFSAYRTGLYEFH-SGSQVKS 198
            .||     ..:..|..|:. :....||..:::|.....:..|...|....|..:.|. :..:|..
  Rat   244 SHI-----LKLTKGLIKEA-LENTDSATQMMILNCIYFKGAWMNKFPVEMTHNHNFRLNEREVVK 302

  Fly   199 VPMLFDDDMFVKFAELRDLDARAIELPYEHAEELSMLLILPNQRGGLQELEKQLHDLDLGALQQR 263
            |.|:.....|:. |..::||...::|  |:...:|||:::|.:..|::.||.||....:...|:.
  Rat   303 VSMMQTKGNFLA-ANDQELDCDILQL--EYVGGISMLIVIPRKLSGMKTLEAQLTPQVVERWQKS 364

  Fly   264 MQMEGVQVLLPKFSIDFECSLRQPLKQLGFEEIFAASANFKHLHASANLPIADVLQ-KLRINLNE 327
            |.....:||||||.::...:|.:.||.:|..::|..:.|...:  |....|.|:.: :..|.:||
  Rat   365 MTNRTREVLLPKFKLEKNYNLVEVLKSMGITKLFNKNGNMSGI--SDQRIIIDLFKHQSTITVNE 427

  Fly   328 SGSGSGPELPKNATEYKPIVISNSSRQKFFRADHPFFFAIRSENVTYL--MGHV 379
            .|:.:.   ......:.|:     |.|..|..|.||.|.:.....:.|  ||.|
  Rat   428 EGTQAA---AVTTVGFMPL-----STQVRFTVDRPFLFLVYEHRTSCLLFMGRV 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn31A	NP_609341.1	SERPIN	18..379	CDD:238101	88/377 (23%)
Serpind1	NP_077358.1	HCII	44..477	CDD:239002	89/379 (23%)
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	55..79
		Glycosaminoglycan-binding site. /evidence=ECO:0000250	172..192		4/28 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020