DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn31A and SERPINA7

DIOPT Version :9

Sequence 1:	NP_609341.1	Gene:	Spn31A / 34339	FlyBaseID:	FBgn0032178	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	XP_006724746.1	Gene:	SERPINA7 / 6906	HGNCID:	11583	Length:	425	Species:	Homo sapiens

Alignment Length:	419	Identity:	86/419 - (20%)
Similarity:	158/419 - (37%)	Gaps:	70/419 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SEAANPTPY-----DCHIGAGIYHSIATSFAEQNVVVSPLLLEATLSLLFLGSDGATAEELQKQL 61
            |...|.|.|     :......:|........::|:..||:.:.|.|.:|..|:..:|..|:.:.|
Human    32 SSQPNATLYKMSSINADFAFNLYRRFTVETPDKNIFFSPVSISAALVMLSFGACCSTQTEIVETL 96

  Fly    62 ----------RLKQRFASNAKMANFYAAELGNITTDADTFLQLQNRLMLSSESGVADDFQKIAQT 116
                      .::..|.......||...||.         ||:.|.|.:.........|....:|
Human    97 GFNLTDTPMVEIQHGFQHLICSLNFPKKELE---------LQIGNALFIGKHLKPLAKFLNDVKT 152

  Fly   117 YFHATAECVDLEQTEKLRRHISEQILASVGGGSWKDIHVAGGSSANTLLLLL-AANLQSKWFLPF 180
            .:.......|.......::.|:..:.....|   |.:.:......||:::|: ..:.:::|..||
Human   153 LYETEVFSTDFSNISAAKQEINSHVEMQTKG---KVVGLIQDLKPNTIMVLVNYIHFKAQWANPF 214

  Fly   181 SAYRTGLYEFHSG-----SQVKSVPMLFDDDMFVKFAELRDLDARAIELPYEHAEELSMLLILPN 240
            ...:|   |..|.     :....|||:...:   ::..|.|::.....|..::::....|.:||.
Human   215 DPSKT---EDSSSFLIDKTTTVQVPMMHQME---QYYHLVDMELNCTVLQMDYSKNALALFVLPK 273

  Fly   241 QRGGLQELEKQLHDLDLGALQQRMQMEGVQVLLPKFSIDFECSLRQPLKQLGFEEIFAASANFKH 305
            : |.::.:|..:....|....:.:|...|.:.:|||||.....|...|.::|.:..::.:|:|..
Human   274 E-GQMESVEAAMSSKTLKKWNRLLQKGWVDLFVPKFSISATYDLGATLLKMGIQHAYSENADFSG 337

  Fly   306 LHAS-----ANLPIADVL-----QKLRINLNESGSGSG--PEL-----PKNATEYKPIVISNSSR 353
            |...     :|.|...||     .|..:::.|.|:.:.  ||:     |:| |...||:
Human   338 LTEDNGLKLSNRPAGFVLPTQAAHKAVLHIGEKGTEAAAVPEVELSDQPEN-TFLHPII------ 395

  Fly   354 QKFFRADHPFFFAI--RSENVTYLMGHVV 380
                :.|..|...|  ||......:|.||
Human   396 ----QIDRSFMLLILERSTRSILFLGKVV 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn31A	NP_609341.1	SERPIN	18..379	CDD:238101	80/395 (20%)
SERPINA7	XP_006724746.1	alpha-1-antitrypsin_like	46..419	CDD:239011	80/402 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010