DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn31A and SERPINB3

DIOPT Version :9

Sequence 1:	NP_609341.1	Gene:	Spn31A / 34339	FlyBaseID:	FBgn0032178	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_008850.1	Gene:	SERPINB3 / 6317	HGNCID:	10569	Length:	390	Species:	Homo sapiens

Alignment Length:	399	Identity:	99/399 - (24%)
Similarity:	179/399 - (44%)	Gaps:	43/399 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSEAANPTPYDCHIGAGIYHSIATSFAEQNVVVSPLLLEATLSLLFLGSDGATAEELQKQLRLKQ 65
            :|||.....:|      ::.....| .|.|:..||:.:.:.|.::.||:...||::::|.|...|
Human     4 LSEANTKFMFD------LFQQFRKS-KENNIFYSPISITSALGMVLLGAKDNTAQQIKKVLHFDQ 61

  Fly    66 -RFASNAKMANFYAAELGNI-------------TTDADTFLQLQNRLMLSSESGVADDFQKIAQT 116
             ...:..|.|.::....||:             :|||.. |::.|:|..........::....:.
Human    62 VTENTTGKAATYHVDRSGNVHHQFQKLLTEFNKSTDAYE-LKIANKLFGEKTYLFLQEYLDAIKK 125

  Fly   117 YFHATAECVDL-----EQTEKLRRHISEQILASVGGGSWKDIHVAGGSSANTLLLLL-AANLQSK 175
            ::..:.|.||.     |..:|:...:..|....:     |::...|...:||.|:|: |...:.:
Human   126 FYQTSVESVDFANAPEESRKKINSWVESQTNEKI-----KNLIPEGNIGSNTTLVLVNAIYFKGQ 185

  Fly   176 WFLPFSAYRTGLYEFHSGSQV-KSVPMLFDDDMFVKFAELRDLDARAIELPYEHAEELSMLLILP 239
            |...|:...|...:|...... ||:.|:.....| .||.|.|:.|:.:|:||: .::|||:::||
Human   186 WEKKFNKEDTKEEKFWPNKNTYKSIQMMRQYTSF-HFASLEDVQAKVLEIPYK-GKDLSMIVLLP 248

  Fly   240 NQRGGLQELEKQL--HDLDLGALQQRMQMEGVQVLLPKFSIDFECSLRQPLKQLGFEEIFAASAN 302
            |:..|||:||::|  ..|......|.|:...|.:.||:|.::....|:..|:.:|..:||...|:
Human   249 NEIDGLQKLEEKLTAEKLMEWTSLQNMRETRVDLHLPRFKVEESYDLKDTLRTMGMVDIFNGDAD 313

  Fly   303 FKHLHASANLPIADVLQKLRINLNESGSGSGPELPKNATEYKPIVISNSSRQKFFRADHPFFFAI 367
            ...:..|..|.::.||.|..:.:.|.|:.:..     ||.......|.:|..:.|..:|||.|.|
Human   314 LSGMTGSRGLVLSGVLHKAFVEVTEEGAEAAA-----ATAVVGFGSSPTSTNEEFHCNHPFLFFI 373

  Fly   368 RSENVTYLM 376
            |......::
Human   374 RQNKTNSIL 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn31A	NP_609341.1	SERPIN	18..379	CDD:238101	95/382 (25%)
SERPINB3	NP_008850.1	serpinB3_B4_SCCA1_2	1..390	CDD:381030	99/399 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.930