DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn31A and SERPINI1

DIOPT Version :9

Sequence 1:	NP_609341.1	Gene:	Spn31A / 34339	FlyBaseID:	FBgn0032178	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_001116224.1	Gene:	SERPINI1 / 5274	HGNCID:	8943	Length:	410	Species:	Homo sapiens

Alignment Length:	394	Identity:	96/394 - (24%)
Similarity:	175/394 - (44%)	Gaps:	54/394 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 IGAGIYHSIATSFAEQNVVVSPLLLEATLSLLFLGSDGATAEELQKQLRLKQRFASNAKMANF-Y 77
            :...:|:.:..:..::|::.|||.:...:.::.||:.|:|    ||::|....:.|......| :
Human    29 LSVNMYNRLRATGEDENILFSPLSIALAMGMMELGAQGST----QKEIRHSMGYDSLKNGEEFSF 89

  Fly    78 AAELGNITT--DADTFLQLQNRLMLSSESGVADDFQKIAQTYFHATAECVDLEQTEKLRRHISEQ 140
            ..|..|:.|  ::...:::.|.|.:.:...|.::|.::.:.||:|....||..|...:..:|::
Human    90 LKEFSNMVTAKESQYVMKIANSLFVQNGFHVNEEFLQMMKKYFNAAVNHVDFSQNVAVANYINK- 153

  Fly   141 ILASVGGGSW---------KDIHVAGGSSANTLLLLL-AANLQSKWFLPFSAYRTGLYEFHSGSQ 195
                     |         ||:.......|.|.|.|: |...:..|...|....|..:.|....:
Human   154 ---------WVENNTNNLVKDLVSPRDFDAATYLALINAVYFKGNWKSQFRPENTRTFSFTKDDE 209

  Fly   196 VK-SVPMLFDDDMFVKFAELRDLDARA------IELPYEHAEELSMLLILPNQRGGLQELEKQLH 253
            .: .:||::....|. :.|..|....|      :|:||| .:|:||:|:|..|...|..||..:.
Human   210 SEVQIPMMYQQGEFY-YGEFSDGSNEAGGIYQVLEIPYE-GDEISMMLVLSRQEVPLATLEPLVK 272

  Fly   254 DLDLGALQQRMQMEGVQVLLPKFSIDFECSLRQPLKQLGFEEIFAASANFKHLHASANLPIADVL 318
            ...:......::.:.|:|.||:|:::.|..|:..||.||..|||...||...|..:..:.::..:
Human   273 AQLVEEWANSVKKQKVEVYLPRFTVEQEIDLKDVLKALGITEIFIKDANLTGLSDNKEIFLSKAI 337

  Fly   319 QKLRINLNESGSGSGP-----ELPKNATEYKPIVISNSSRQKFFRADHPFFFAIRSENV-TYL-M 376
            .|..:.:||.||.:..     .:.:.|..|..:::           ||||||.||:... |.| |
Human   338 HKSFLEVNEEGSEAAAVSGMIAISRMAVLYPQVIV-----------DHPFFFLIRNRRTGTILFM 391

  Fly   377 GHVV 380
            |.|:
Human   392 GRVM 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn31A	NP_609341.1	SERPIN	18..379	CDD:238101	95/387 (25%)
SERPINI1	NP_001116224.1	neuroserpin	23..410	CDD:239003	96/394 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.030