DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn31A and SERPINB6

DIOPT Version :9

Sequence 1:	NP_609341.1	Gene:	Spn31A / 34339	FlyBaseID:	FBgn0032178	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	XP_011512974.1	Gene:	SERPINB6 / 5269	HGNCID:	8950	Length:	454	Species:	Homo sapiens

Alignment Length:	393	Identity:	95/393 - (24%)
Similarity:	167/393 - (42%)	Gaps:	64/393 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 HIGAGIYHSIAT---SFA-----------EQNVVVSPLLLEATLSLLFLGSDGATAEELQKQLR- 62
            ||.:.|...:|.   :||           .:||..||:.:...|:::::|:.|.||.::.:.|.
Human    73 HIKSAIMDVLAEANGTFALNLLKTLGKDNSKNVFFSPMSMSCALAMVYMGAKGNTAAQMAQILSF 137

  Fly    63 --------LKQRFASNAKMANFYAAELGNITTDADTFLQLQNRLMLSSESGVADDFQKIAQTYFH 119
                    :.|.|.|.....|         .|.....|::.|||...........|:...|.::.
Human   138 NKSGGGGDIHQGFQSLLTEVN---------KTGTQYLLRMANRLFGEKSCDFLSSFRDSCQKFYQ 193

  Fly   120 ATAECVD-LEQTEKLRRHISEQILASVGGGSWKDIHVAGGSSANTLLLLLAANLQSKWFLPFSAY 183
            |..|.:| :...||.|:||:..:.....|...:.:..........|:|:.|...:..|...|...
Human   194 AEMEELDFISAVEKSRKHINTWVAEKTEGKIAELLSPGSVDPLTRLVLVNAVYFRGNWDEQFDKE 258

  Fly   184 RTGLYEFH-SGSQVKSVPMLFDDDMFVKFAELRDLDARAIELPYEHAEELSMLLILPNQRGGLQE 247
            .|....|. |.::.|.|.|:|....|.| ..:.::..:.:.|||. .:||:|:::||::...|:.
Human   259 NTEERLFKVSKNEEKPVQMMFKQSTFKK-TYIGEIFTQILVLPYV-GKELNMIIMLPDETTDLRT 321

  Fly   248 LEKQL--------HDLDLGALQQRMQMEGVQVLLPKFSIDFECSLRQPLKQLGFEEIF-AASANF 303
            :||:|        ..||:      |..|.|:|.||:|.::....:...|:.||..:.| ...|:|
Human   322 VEKELTYEKFVEWTRLDM------MDEEEVEVSLPRFKLEESYDMESVLRNLGMTDAFELGKADF 380

  Fly   304 KHLHASANLPIADVLQKLRINLNESGSGSGPELPKNATEYKPIVISNSSRQKF---FRADHPFFF 365
            ..: :..:|.::.|:.|..:.:||.|:       :.|.....|::...:|  |   |.|||||.|
Human   381 SGM-SQTDLSLSKVVHKSFVEVNEEGT-------EAAAATAAIMMMRCAR--FVPRFCADHPFLF 435

  Fly   366 AIR 368
            .|:
Human   436 FIQ 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn31A	NP_609341.1	SERPIN	18..379	CDD:238101	93/388 (24%)
SERPINB6	XP_011512974.1	PAI-2	82..454	CDD:239013	92/384 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.930