DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn31A and SERPINF1

DIOPT Version :9

Sequence 1:	NP_609341.1	Gene:	Spn31A / 34339	FlyBaseID:	FBgn0032178	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_001316832.1	Gene:	SERPINF1 / 5176	HGNCID:	8824	Length:	418	Species:	Homo sapiens

Alignment Length:	403	Identity:	80/403 - (19%)
Similarity:	159/403 - (39%)	Gaps:	82/403 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 HIGAGIYHSIATSFAEQNVVVSPLLLEATLSLLFLGSDGATAEELQKQLRLKQRFASNAKMANFY 77
            :.|..:|...:::....||::|||.:...||.|.||::..|...:.:.|...  ..|:..:...|
Human    60 NFGYDLYRVRSSTSPTTNVLLSPLSVATALSALSLGAEQRTESIIHRALYYD--LISSPDIHGTY 122

  Fly    78 AAELGNITTDADTFLQLQNRLMLSSESGVADDFQKIAQTYFHATAECVDLEQTEKLRRHI----- 137
            ...|..:|..... |:..:|::...:..:...|             ...||::...|..:
Human   123 KELLDTVTAPQKN-LKSASRIVFEKKLRIKSSF-------------VAPLEKSYGTRPRVLTGNP 173

  Fly   138 ---SEQILASVGGGSWKDIHVAGGSSANT--------LLLLLAANLQSKWFLPFSAYRTGLYEFH 191
               .::|      .:|....:.|..:.:|        :|||..|:.:.:|...|.:.:|.|.:|:
Human   174 RLDLQEI------NNWVQAQMKGKLARSTKEIPDEISILLLGVAHFKGQWVTKFDSRKTSLEDFY 232

  Fly   192 -SGSQVKSVPMLFDDDMFVKFAELRDLDARAIELPYEHAEELSMLLILP-NQRGGLQELEKQL-- 252
             ...:...|||:.|....:::....||..:..:||.  ...:|::..|| .....|..:|:.|
Human   233 LDEERTVRVPMMSDPKAVLRYGLDSDLSCKIAQLPL--TGSMSIIFFLPLKVTQNLTLIEESLTS 295

  Fly   253 ---HDLDLGALQQRMQMEGVQVLL--PKFSIDFECSLRQPLKQLGFEEIFAASANFKHLHASANL 312
               ||:|       .:::.||.:|  ||..:.:|..:.:.|:::..:.:| .|.:|..: ....:
Human   296 EFIHDID-------RELKTVQAVLTVPKLKLSYEGEVTKSLQEMKLQSLF-DSPDFSKI-TGKPI 351

  Fly   313 PIADVLQKLRINLNESGSGSGPE---LPKNATEYKPIVISNSSRQKFFRADH----PFFFAIRSE 370
            .:..|..:.....||.|:|:.|.   .|.:.|               |..|:    ||.|.:|..
Human   352 KLTQVEHRAGFEWNEDGAGTTPSPGLQPAHLT---------------FPLDYHLNQPFIFVLRDT 401

  Fly   371 NVTYLM--GHVVE 381
            :...|:  |.:::
Human   402 DTGALLFIGKILD 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn31A	NP_609341.1	SERPIN	18..379	CDD:238101	79/394 (20%)
SERPINF1	NP_001316832.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..39
		PEDF	40..415	CDD:239007	80/403 (20%)
		O-glycosylated at one site	371..383		2/11 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010