Protein Alignment Spn31A and SERPINB1

DIOPT Version :10

• Sequence 1: NP_609341.1
• Gene: Spn31A / 34339
• FlyBaseID: FBgn0032178
• Length: 382
• Species: Drosophila melanogaster
• Sequence 2: NP_109591.1
• Gene: SERPINB1 / 1992
• HGNCID: 3311
• Length: 379
• Species: Homo sapiens
• Alignment Length: 368
• Identity: 96/368 - (26%)
• Similarity: 164/368 - (44%)
• Gaps: 43/368 - (11%)

  Fly    30 NVVVSPLLLEATLSLLFLGSDGATAEELQKQL------RLKQRFAS-NAKMANFYAAELGNITTD 87
            |:.:||..:.:.::::|||:.|.||.:|.|..      .:..||.| ||.:..          ..
Human    27 NIFISPFSISSAMAMVFLGTRGNTAAQLSKTFHFNTVEEVHSRFQSLNADINK----------RG 81

  Fly    88 ADTFLQLQNRLMLSSESGVADDFQKIAQTYFHATAECVDLEQTEKLRRHISEQILASVGGGSWKD 152
            |...|:|.|||..........:|....|..:.|....||.:...:..|....|.:.....|...:
Human    82 ASYILKLANRLYGEKTYNFLPEFLVSTQKTYGADLASVDFQHASEDARKTINQWVKGQTEGKIPE 146

  Fly   153 IHVAGGSSANTLLLLL-AANLQSKWFLPFSAYRTGLYEFH-SGSQVKSVPMLFDDDMFVKFAELR 215
            :..:|.....|.|:|: |...:..|...|....|....|. :....|:|.|::....|. :..:.
Human   147 LLASGMVDNMTKLVLVNAIYFKGNWKDKFMKEATTNAPFRLNKKDRKTVKMMYQKKKFA-YGYIE 210

  Fly   216 DLDARAIELPYEHAEELSMLLILP----NQRGGLQELEKQLHDLDLGALQQRMQMEG-----VQV 271
            ||..|.:||||: .|||||:::||    ::..||:::|:|   |.|..|.:..:.|.     |.|
Human   211 DLKCRVLELPYQ-GEELSMVILLPDDIEDESTGLKKIEEQ---LTLEKLHEWTKPENLDFIEVNV 271

  Fly   272 LLPKFSIDFECSLRQPLKQLGFEEIFAAS-ANFKHLHASANLPIADVLQKLRINLNESGSGSGPE 335
            .||:|.::...:|...|.:||.:::|.:| |:...:..:.::.|:.::.|..:.:||.|:.:...
Human   272 SLPRFKLEESYTLNSDLARLGVQDLFNSSKADLSGMSGARDIFISKIVHKSFVEVNEEGTEAAAA 336

  Fly   336 LPKNATEYKPIVISNSSRQKFFRADHPFFFAIR---SENVTYL 375
            ....||....:...|      |.|||||.|.||   |.::.:|
Human   337 TAGIATFCMLMPEEN------FTADHPFLFFIRHNSSGSILFL 373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn31A	NP_609341.1	serpin42Dd-like_insects	10..382	CDD:381070	96/368 (26%)
SERPINB1	NP_109591.1	serpinB1_LEI	1..379	CDD:381028	96/368 (26%)
		CARD-binding motif (CBM). /evidence=ECO:0000269|PubMed:30692621	351..379		12/29 (41%)