Protein Alignment Spn31A and SERPINA12

DIOPT Version :10

• Sequence 1: NP_609341.1
• Gene: Spn31A / 34339
• FlyBaseID: FBgn0032178
• Length: 382
• Species: Drosophila melanogaster
• Sequence 2: NP_776249.1
• Gene: SERPINA12 / 145264
• HGNCID: 18359
• Length: 414
• Species: Homo sapiens
• Alignment Length: 366
• Identity: 81/366 - (22%)
• Similarity: 158/366 - (43%)
• Gaps: 40/366 - (10%)

  Fly    29 QNVVVSPLLLEATLSLLFLGSDGATAEELQKQLRLKQRFASNAKMANFYAA-ELGNITTDADTFL 92
            :|:.:|||.:....|:|.||:..:|.:|:::....::....:......|.. ||...|.|..  |
Human    70 RNIFLSPLSISTAFSMLCLGAQDSTLDEIKQGFNFRKMPEKDLHEGFHYIIHELTQKTQDLK--L 132

  Fly    93 QLQNRLMLSSESGVADDFQKIAQTYFHATAECVDLEQTEKLRRHISEQILASVGGGSWKDIHVAG 157
            .:.|.|.:.........|.:.|:.::.|.....:.:..|..::.|::.|.....|   |..::..
Human   133 SIGNTLFIDQRLQPQRKFLEDAKNFYSAETILTNFQNLEMAQKQINDFISQKTHG---KINNLIE 194

  Fly   158 GSSANTLLLLLAAN---LQSKWFLPFSAYRTGLYEF--HSGSQVKSVPMLFDDDMF-VKFAELRD 216
            .....|::||  ||   .:::|...|....|...:|  ...|.|| |||:|...:: |.:.:  .
Human   195 NIDPGTVMLL--ANYIFFRARWKHEFDPNVTKEEDFFLEKNSSVK-VPMMFRSGIYQVGYDD--K 254

  Fly   217 LDARAIELPYEHAEELSMLLILPNQRGGLQELEKQLHDLDLGALQQRMQMEGVQVLLPKFSIDFE 281
            |....:|:||:  :.::.:.|||:: |.|:.|||.|........:..:....|.|.:|:..:...
Human   255 LSCTILEIPYQ--KNITAIFILPDE-GKLKHLEKGLQVDTFSRWKTLLSRRVVDVSVPRLHMTGT 316

  Fly   282 CSLRQPLKQLGFEEIFAASANFKHLHASANLPIADVLQKLRINLNESG----SGSGPE-LPKNAT 341
            ..|::.|..:|..:||....:...:....:|.:.:.:.|..:.::|.|    :|:|.: ||...
Human   317 FDLKKTLSYIGVSKIFEEHGDLTKIAPHRSLKVGEAVHKAELKMDERGTEGAAGTGAQTLPMET- 380

  Fly   342 EYKPIVISNSSRQKFFRADHPFFFAIRSENV--TYLMGHVV 380
               |:|:         :.|.|:...|.||.:  ...:|.:|
Human   381 ---PLVV---------KIDKPYLLLIYSEKIPSVLFLGKIV 409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn31A	NP_609341.1	serpin42Dd-like_insects	10..382	CDD:381070	81/366 (22%)
SERPINA12	NP_776249.1	serpinA12_vaspin	40..411	CDD:381026	81/366 (22%)
		Reactive center loop. /evidence=ECO:0000269|PubMed:26529565, ECO:0000305|PubMed:23370777, ECO:0000305|PubMed:26199422	364..382		5/21 (24%)