DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn31A and Serping1

DIOPT Version :9

Sequence 1:	NP_609341.1	Gene:	Spn31A / 34339	FlyBaseID:	FBgn0032178	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_033906.2	Gene:	Serping1 / 12258	MGIID:	894696	Length:	504	Species:	Mus musculus

Alignment Length:	406	Identity:	78/406 - (19%)
Similarity:	153/406 - (37%)	Gaps:	104/406 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 IYHSI-ATSFAEQNVVVSPLLLEATLSLLFLGSDGATAEELQKQLRLKQRFASNAKMANFYAAEL 81
            :||:. ||..|:.|:..||..:.:.|:.:.||:..:|...|:..|...:.||...:....::::
Mouse   158 LYHAFSATKMAKTNMAFSPFSIASLLTQVLLGAGDSTKSNLESILSYPKDFACVHQALKGFSSK- 221

  Fly    82 GNITTDADTFLQLQNRLMLSSESGVADDFQKIAQTYFHATAECVDLEQTEKLR----------RH 136
             .:|:.:..|        .|.:..:.|.:...:|:.:.::...:..:....|.          .|
Mouse   222 -GVTSVSQIF--------HSPDLAIRDTYVNASQSLYGSSPRVLGPDSAANLELINTWVAENTNH 277

  Fly   137 ISEQILASVGGGSWKDIHVAGGSSANTLLLLLAANLQSKWFLPFSAYRTGLYEFHSGSQVKSVPM 201
            ...::|.|:             .|...|:||.|..|.:||.:.|...:.....|:..|.:| |||
Mouse   278 KIRKLLDSL-------------PSDTCLVLLNAVYLSAKWKITFEPKKMMAPFFYKNSMIK-VPM 328

  Fly   202 L---------FDDDMFVKFAELRDLDARAIELPYEHAEELSMLLILP-NQRGGLQELEKQLHDLD 256
            :         |||         ..|.|:..:|...|  .||.::::| ..:..|:::||.|:...
Mouse   329 MSSVKYPVAQFDD---------HTLKAKVGQLQLSH--NLSFVIVVPVFPKHQLKDVEKALNPTV 382

  Fly   257 LGALQQRMQMEGVQVLLPKFSIDFECSLRQPLKQLGFEEIFAASANFKHLHASANLPIADVLQKL 321
            ..|:.:::::   ...||.:       |..|                 |:...::..:..|::||
Mouse   383 FKAIMKKLEL---SKFLPTY-------LTMP-----------------HIKVKSSQDMLSVMEKL 420

  Fly   322 RI-----NLNESGSGSGPELPKNATEYKPIV--------------ISNSSRQKFFRADHPFFFAI 367
            ..     :||..|....|:|..:|.:::.::              ||.......|....||.|.:
Mouse   421 EFFDFTYDLNLCGLTEDPDLQVSAMKHETVLELTESGVEAAAASAISFGRSLPIFEVQRPFLFLL 485

  Fly   368 --RSENVTYLMGHVVE 381
              :.......||.|.:
Mouse   486 WDQQHRFPVFMGRVYD 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn31A	NP_609341.1	SERPIN	18..379	CDD:238101	77/402 (19%)
Serping1	NP_033906.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..67
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	85..141
		serpinG1_C1-INH	141..500	CDD:381006	77/403 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100