DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pen and SRP1

DIOPT Version :9

Sequence 1:	NP_477041.1	Gene:	Pen / 34338	FlyBaseID:	FBgn0267727	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_014210.1	Gene:	SRP1 / 855532	SGDID:	S000005133	Length:	542	Species:	Saccharomyces cerevisiae

Alignment Length:	520	Identity:	219/520 - (42%)
Similarity:	314/520 - (60%)	Gaps:	29/520 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 QGSYKANSINTQDSRMRRHEVTIELRKSKKEDQMFKRRNI---------NDEDLTSPLKELNGQS 65
            :|.:.|:.:     |.||....:||||:|:::.:.||||.         ::||.:|...:....|
Yeast    24 KGRFSADEL-----RRRRDTQQVELRKAKRDEALAKRRNFIPPTDGADSDEEDESSVSADQQFYS 83

  Fly    66 PVQLSVDEIVAAMNSEDQERQFLGMQSARKMLSRERNPPIDLMIGHGIVPICIRFLQNTNNSMLQ 130
            .:|..:.::...:||:|.:.|.......|::||||..||||::|..|:||..:.|::.....|||
Yeast    84 QLQQELPQMTQQLNSDDMQEQLSATVKFRQILSREHRPPIDVVIQAGVVPRLVEFMRENQPEMLQ 148

  Fly   131 FEAAWALTNIASGTSDQTRCVIEHNAVPHFVALLQSKSMNLAEQAVWALGNIAGDGAAARDIVIH 195
            .||||||||||||||.||:.|::.:|||.|:.||.:.|:.:.|||:|||||:|||....||.|:.
Yeast   149 LEAAWALTNIASGTSAQTKVVVDADAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYRDYVLQ 213

  Fly   196 HNVIDGILPLINNETPLSFLRNIVWLMSNLCRNKNPSPPFDQVKRLLPVLSQLLLSQDIQVLADA 260
            .|.::.||.|.|:..| |.:|...|.:|||||.|.|.|.:..|.:.||.|::|:.|.|.:.|.||
Yeast   214 CNAMEPILGLFNSNKP-SLIRTATWTLSNLCRGKKPQPDWSVVSQALPTLAKLIYSMDTETLVDA 277

  Fly   261 CWALSYVTDDDNTKIQAVVDSDAVPRLVKLLQMDEPSIIVPALRSVGNIVTGTDQQTDVVIASGG 325
            |||:||::|.....||||:|.....|||:||..:...:..||||:|||||||.|.||.|||.:|.
Yeast   278 CWAISYLSDGPQEAIQAVIDVRIPKRLVELLSHESTLVQTPALRAVGNIVTGNDLQTQVVINAGV 342

  Fly   326 LPRLGLLLQHNKSNIVKEAAWTVSNITAGNQKQIQAVIQAGIFQQLRTVLEKGDFKAQKEAAWAV 390
            ||.|.|||...|.||.|||.||:|||||||.:||||||.|.:...|..:||..::|.:|||.||:
Yeast   343 LPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPPLVKLLEVAEYKTKKEACWAI 407

  Fly   391 TNTTTSGTPEQIVDLIEKYKI----LKPFIDLLDTKDPRTIKVVQTGLSNLFALAEK------LG 445
            :|.::.|.  |..|:| :|.:    :||..|||:..|.|.|:|....|.|:..:.|.      |.
Yeast   408 SNASSGGL--QRPDII-RYLVSQGCIKPLCDLLEIADNRIIEVTLDALENILKMGEADKEARGLN 469

  Fly   446 GTENLCLMVEEMGGLDKLETLQQHENEEVYKKAYAIIDTYFSNGDDEAEQELAPQEVNGALEFNA 510
            ..|| ...:|:.||::|:...||:||:::|:|||.||:|||...:|..::.:|||.......|.:
Yeast   470 INEN-ADFIEKAGGMEKIFNCQQNENDKIYEKAYKIIETYFGEEEDAVDETMAPQNAGNTFGFGS 533

Fly 511 510
Yeast 534 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pen	NP_477041.1	SRP1	2..517	CDD:227396	219/520 (42%)
		HEAT repeat	70..102	CDD:293787	9/31 (29%)
		armadillo repeat	108..140	CDD:293788	15/31 (48%)
		armadillo repeat	148..184	CDD:293788	17/35 (49%)
		armadillo repeat	190..225	CDD:293788	13/34 (38%)
		armadillo repeat	359..396	CDD:293788	16/36 (44%)
		armadillo repeat	402..437	CDD:293788	13/38 (34%)
SRP1	NP_014210.1	SRP1	8..542	CDD:227396	219/520 (42%)
		armadillo repeat	89..114	CDD:293788	5/24 (21%)
		armadillo repeat	125..158	CDD:293788	15/32 (47%)
		armadillo repeat	166..202	CDD:293788	17/35 (49%)
		armadillo repeat	208..242	CDD:293788	13/34 (38%)
		armadillo repeat	259..284	CDD:293788	13/24 (54%)
		armadillo repeat	294..326	CDD:293788	14/31 (45%)
		armadillo repeat	334..370	CDD:293788	22/35 (63%)
		armadillo repeat	376..409	CDD:293788	15/32 (47%)
		armadillo repeat	421..455	CDD:293788	12/34 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342245
Domainoid	1	1.000	56	1.000	Domainoid score	I2722
eggNOG	1	0.900	-	-		E1_COG5064
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54553
OrthoFinder	1	1.000	-	-		FOG0000157
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100442
Panther	1	1.100	-	-	O	PTHR23316
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.750