Protein Alignment Pen and Kpna2

DIOPT Version :10

• Sequence 1: NP_477041.1
• Gene: Pen / 34338
• FlyBaseID: FBgn0287720
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_445935.2
• Gene: Kpna2 / 85245
• RGDID: 621419
• Length: 529
• Species: Rattus norvegicus
• Alignment Length: 522
• Identity: 264/522 - (50%)
• Similarity: 355/522 - (68%)
• Gaps: 11/522 - (2%)

  Fly     8 SRQGSYKANSINTQDSRMRRHEVTIELRKSKKEDQMFKRRNIND--EDLTSPLKE-LNGQSPVQL 69
            :|...:|....::.:.|.||.||.:||||:||:|||.||||::.  :|.||||:| .|.|..|..
  Rat    12 ARLNRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNW 76

  Fly    70 SVDEIVAAMNSEDQERQFLGMQSARKMLSRERNPPIDLMIGHGIVPICIRFLQNTNNSMLQFEAA 134
            ||::||..:||.:.|.|....|:|||:||||:.||||.:|..|::|..:.||..|:.|.:|||:|
  Rat    77 SVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESA 141

  Fly   135 WALTNIASGTSDQTRCVIEHNAVPHFVALLQSKSMNLAEQAVWALGNIAGDGAAARDIVIHHNVI 199
            |||||||||||:||:.|::..|:|.|::||.|...:::||||||||||||||:..||:||.|..|
  Rat   142 WALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKHGAI 206

  Fly   200 DGILPLIN----NETPLSFLRNIVWLMSNLCRNKNPSPPFDQVKRLLPVLSQLLLSQDIQVLADA 260
            |.:|.|:.    :.....:|||:.|.:|||||||||:||.|.|:::||.|.:||...|.:||||:
  Rat   207 DPLLALLAVPDLSSLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADS 271

  Fly   261 CWALSYVTDDDNTKIQAVVDSDAVPRLVKLLQMDEPSIIVPALRSVGNIVTGTDQQTDVVIASGG 325
            |||:||:||..|.:|:.||....||:|||||...|..|:.||||::||||||||:||..||.:|.
  Rat   272 CWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGTDEQTQKVIDAGA 336

  Fly   326 LPRLGLLLQHNKSNIVKEAAWTVSNITAGNQKQIQAVIQAGIFQQLRTVLEKGDFKAQKEAAWAV 390
            |.....||.:.|:||.|||.||:||||||.|.|||.|:..|:...|..||.|.|||.|||||||:
  Rat   337 LAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAI 401

  Fly   391 TNTTTSGTPEQIVDLIEKYKILKPFIDLLDTKDPRTIKVVQTGLSNLFALAEKLGGTENLCLMVE 455
            ||.|:.||.||||.|:. ..|::|.::||..||.:.|:|:...:||:|..|||||.||.|.:|:|
  Rat   402 TNYTSGGTVEQIVYLVH-CGIIEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIE 465

  Fly   456 EMGGLDKLETLQQHENEEVYKKAYAIIDTYFSNGDDEAEQELAPQEVNGALEFNATQPKAPEGGY 520
            |.|||||:|.||.||||.|||.:..:|:.||| .::|.:|.:.|:..:....|. .|..|| |.:
  Rat   466 ECGGLDKIEALQSHENESVYKASLNLIEKYFS-VEEEEDQNVVPETTSEGFAFQ-VQDGAP-GTF 527

  Fly   521 TF 522
            .|
  Rat   528 NF 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pen	NP_477041.1	SRP1	2..517	CDD:227396	261/515 (51%)
		HEAT repeat	70..102	CDD:293787	16/31 (52%)
		armadillo repeat	108..140	CDD:293788	15/31 (48%)
		armadillo repeat	148..184	CDD:293788	18/35 (51%)
		armadillo repeat	190..225	CDD:293788	14/38 (37%)
		armadillo repeat	359..396	CDD:293788	21/36 (58%)
		armadillo repeat	402..437	CDD:293788	12/34 (35%)
Kpna2	NP_445935.2	SRP1	12..528	CDD:227396	263/519 (51%)
		armadillo repeat	115..147	CDD:293788	15/31 (48%)
		armadillo repeat	155..191	CDD:293788	18/35 (51%)
		armadillo repeat	197..236	CDD:293788	14/38 (37%)
		armadillo repeat	253..278	CDD:293788	14/24 (58%)
		armadillo repeat	288..320	CDD:293788	16/31 (52%)
		armadillo repeat	328..364	CDD:293788	18/35 (51%)
		armadillo repeat	370..404	CDD:293788	19/33 (58%)
		armadillo repeat	413..447	CDD:293788	12/34 (35%)
		HEAT repeat	457..494	CDD:293787	22/36 (61%)