Protein Alignment Pen and Tmco6

DIOPT Version :10

• Sequence 1: NP_477041.1
• Gene: Pen / 34338
• FlyBaseID: FBgn0287720
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_082312.3
• Gene: Tmco6 / 71983
• MGIID: 1919233
• Length: 494
• Species: Mus musculus
• Alignment Length: 536
• Identity: 113/536 - (21%)
• Similarity: 218/536 - (40%)
• Gaps: 124/536 - (23%)

  Fly     7 NSRQGSYKANSINTQDSRMRRHEVTIELRKSKKEDQMFKRRNINDEDLTSPLKELNGQS-PVQLS 70
            |.|||..:..:...::.|.||.|....|||:::|.|:..:|.:.::   :| :|:.||| .|.|.
Mouse     3 NRRQGRLRTLAFGVEELRRRRREREAALRKARREQQLVSKRLLRED---AP-EEVGGQSAAVLLG 63

  Fly    71 VDEI-----VAAMNSEDQERQFLGMQSARKMLSRERNPPIDLMIGHGIVPICIRFLQNTNNSMLQ 130
            ..|:     :|...::::||: ..:.|.|:.|.........:.: .|.:...:..| .:|.::||
Mouse    64 EAEVQQFLRLAQRGTDEKERE-KALVSLRRGLQHPDTQQTFIRL-EGSMRTLVGIL-TSNRALLQ 125

  Fly   131 FEAAWALTNIASGTSDQT----RCVIEHNAVPHFVALLQSKSMNLAEQAVWALGNIAGDGAAARD 191
            .|||..|..::.  |:|:    .|:   .|..:.:..|...|.:..|..::.|||:..:..|.|.
Mouse   126 LEAARCLHELSH--SEQSAVAEACL---PATSYLLTYLSGHSSDFIELCLYTLGNLIVESEAVRK 185

  Fly   192 IVIHHNVIDGILPLINNETP-LSFLRNIVWLMSNLCRNKNPSPPFDQVKRLLPVLSQLLLSQ--- 252
            .::...::......|  ::| ::.|..:.:.:|.|.:.|      :..::::|.:....|.|
Mouse   186 QLLPQGIVPAFAACI--QSPHVAVLEALGYALSQLLQAK------EAPEKIIPSILDSSLPQQML 242

  Fly   253 ---------DIQVLADACWALSYV--TDDDNTKIQAVVDSDAVPRLVKLL--------QMDEPS- 297
                     ::.|..:..|.|.|:  :..:|.   .::...|:|.|..||        :||:..
Mouse   243 WLMQPGPKLNLGVAMEFAWCLHYIICSQVNNA---VLLTHGALPTLALLLLDLAGTVQRMDDVGL 304

  Fly   298 --IIVPALRSVGNIVTGT-----DQQTDV----VIASGGLPRLGLLLQ---HNKSNIVKEAAWTV 348
              :..|.||.:.|::|..     .||.::    ::|:     |.:.||   ..:..::.|..|.:
Mouse   305 ELLACPVLRCLSNLLTEVPAEVMGQQMELRDERLVAA-----LFIFLQFFLQKQPALLPEGLWLL 364

  Fly   349 SNITAGNQKQIQAVIQAGIFQQLR------------------TVLEKGDFKAQKEAAW------A 389
            :|:||.:.....:::...:.:.|.                  .|:|||....|:  .|      .
Mouse   365 NNLTANSPTFCTSLLSLDLIEPLLQLLPLSNAVCMLVLTVLCNVVEKGPAYCQR--LWPGPLLSC 427

  Fly   390 VTNTTTSGTPEQIVDLIEKYKILKPFIDLLDTKDPRTIK--VVQTGLSNLFALAEKLGGTENLCL 452
            |.||......|.:...:|       .:.||....|...:  :.|:||..|    |||
Mouse   428 VLNTLALSDTEVVGQSLE-------LLQLLFLHQPEAARAFLQQSGLQAL----EKL-------- 473

  Fly   453 MVEEMGGLDKLETLQQ 468
             .||....:::..|||
Mouse   474 -QEETQLQERIHALQQ 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pen	NP_477041.1	SRP1	2..517	CDD:227396	113/536 (21%)
		HEAT repeat	70..102	CDD:293787	7/36 (19%)
		armadillo repeat	108..140	CDD:293788	9/31 (29%)
		armadillo repeat	148..184	CDD:293788	8/39 (21%)
		armadillo repeat	190..225	CDD:293788	5/35 (14%)
		armadillo repeat	359..396	CDD:293788	10/60 (17%)
		armadillo repeat	402..437	CDD:293788	7/36 (19%)
Tmco6	NP_082312.3	SRP1	23..>391	CDD:227396	81/395 (21%)
		armadillo repeat	104..135	CDD:293788	9/32 (28%)
		armadillo repeat	143..178	CDD:293788	8/37 (22%)
		armadillo repeat	184..218	CDD:293788	5/35 (14%)