DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pen and kpna6

DIOPT Version :9

Sequence 1:	NP_477041.1	Gene:	Pen / 34338	FlyBaseID:	FBgn0267727	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001008018.1	Gene:	kpna6 / 493380	XenbaseID:	XB-GENE-946491	Length:	534	Species:	Xenopus tropicalis

Alignment Length:	533	Identity:	254/533 - (47%)
Similarity:	339/533 - (63%)	Gaps:	17/533 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SKADSNSRQGSYKANSINTQDSRMRRHEVTIELRKSKKEDQMFKRRNIN--DED---LTSPLKE- 60
            |....|||..|:|..::|.::.|.||.|..|:|||.|:|.|:|||||:.  .||   ...||.:
Frog     3 SPGKENSRMKSFKNKALNPEEMRRRREEEGIQLRKQKREQQLFKRRNVELAPEDSSMFDGPLMDS 67

  Fly    61 -LNGQSPVQ-LSVDEIVAAMNSEDQERQFLGMQSARKMLSRERNPPIDLMI-GHGIVPICIRFLQ 122
             ::..:|.. :...|:||.:.|:|.:.|....|..||:||:|.|||||.:| ..|:|...:.||:
Frog    68 YVSSTTPGDGVITREMVALLLSDDPDLQLATTQKFRKLLSKEPNPPIDEVINAPGVVERFVEFLK 132

  Fly   123 NTNNSMLQFEAAWALTNIASGTSDQTRCVIEHNAVPHFVALLQSKSMNLAEQAVWALGNIAGDGA 187
            .::|..|||||||||||||||||.||:.|||..|||.|:.||.|...::.|||||||||||||.:
Frog   133 KSDNYTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIQLLNSDYEDVQEQAVWALGNIAGDSS 197

  Fly   188 AARDIVIHHNVIDGILPLINNETPLSFLRNIVWLMSNLCRNKNPSPPFDQVKRLLPVLSQLLLSQ 252
            ..||.|:..:::..:|.|:...|.|:..||.||.:|||||.|||.|.||:|.:.|||||:||.|.
Frog   198 VCRDYVLSCDILPPLLNLLTKSTRLTMTRNAVWALSNLCRGKNPPPDFDKVSQCLPVLSRLLFSS 262

  Fly   253 DIQVLADACWALSYVTDDDNTKIQAVVDSDAVPRLVKLLQMDEPSIIVPALRSVGNIVTGTDQQT 317
            |..:||||||||||::|..|.|||||:||....|||:||..::..:..||||:|||||||.|.||
Frog   263 DSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPALRAVGNIVTGDDIQT 327

  Fly   318 DVVIASGGLPRLGLLLQHNKSNIVKEAAWTVSNITAGNQKQIQAVIQAGIFQQLRTVLEKGDFKA 382
            .|::....||.|..||...|.:|.|||.||:|||||||:.|||||..|.||..|..:|:|.:|:.
Frog   328 QVILNCSALPCLLHLLSSPKESIRKEACWTISNITAGNRGQIQAVADANIFPVLIEILQKAEFRT 392

  Fly   383 QKEAAWAVTNTTTSGTPEQIVDLIEKYKILKPFIDLLDTKDPRTIKVVQTGLSNLFALAE---KL 444
            :||||||:||.|:.||||||..|: ....:||..|||...|.:.::|...||.|:..|.|   |.
Frog   393 RKEAAWAITNATSGGTPEQIRYLV-NLGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKQ 456

  Fly   445 GGT--ENLCLMVEEMGGLDKLETLQQHENEEVYKKAYAIIDTYFSNGDDEAEQELAPQEVNGALE 507
            ||.  ...|.::||..||||:|.||.|||:|:|:||:.:|:.||  |.:|.:.:|.|.......:
Frog   457 GGNGINPYCGLIEEAYGLDKIEFLQSHENQEIYQKAFELIEHYF--GVEEDDPQLVPSVDESQQQ 519

  Fly   508 FNATQPKAPEGGY 520
            :...|.:||..|:
Frog   520 YIFQQTEAPMEGF 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pen	NP_477041.1	SRP1	2..517	CDD:227396	252/528 (48%)
		HEAT repeat	70..102	CDD:293787	12/31 (39%)
		armadillo repeat	108..140	CDD:293788	16/32 (50%)
		armadillo repeat	148..184	CDD:293788	21/35 (60%)
		armadillo repeat	190..225	CDD:293788	12/34 (35%)
		armadillo repeat	359..396	CDD:293788	20/36 (56%)
		armadillo repeat	402..437	CDD:293788	11/34 (32%)
kpna6	NP_001008018.1	SRP1	33..511	CDD:227396	238/480 (50%)
		armadillo repeat	117..150	CDD:293788	16/32 (50%)
		armadillo repeat	158..194	CDD:293788	21/35 (60%)
		armadillo repeat	200..235	CDD:293788	12/34 (35%)
		armadillo repeat	252..277	CDD:293788	18/24 (75%)
		armadillo repeat	285..321	CDD:293788	19/35 (54%)
		armadillo repeat	327..361	CDD:293788	15/33 (45%)
		armadillo repeat	369..405	CDD:293788	19/35 (54%)
		armadillo repeat	412..446	CDD:293788	11/34 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1111872at2759
OrthoFinder	1	1.000	-	-		FOG0000157
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010