Protein Alignment Pen and kpna2

DIOPT Version :10

• Sequence 1: NP_477041.1
• Gene: Pen / 34338
• FlyBaseID: FBgn0287720
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_001002335.1
• Gene: kpna2 / 436607
• ZFINID: ZDB-GENE-040718-22
• Length: 525
• Species: Danio rerio
• Alignment Length: 530
• Identity: 265/530 - (50%)
• Similarity: 359/530 - (67%)
• Gaps: 24/530 - (4%)

  Fly     1 MSKADSN-SRQGSYKANSINTQDSRMRRHEVTIELRKSKKEDQMFKRRNIND--EDLTSPLKELN 62
            ||.|:.| :|...:|....:..:.|.||.||.:||||:||::|:.||||::.  ::.||||:|.:
Zfish     1 MSAANENTARLTQFKNKGKDATELRRRRIEVNVELRKAKKDEQILKRRNVSSFPDEATSPLQEKS 65

  Fly    63 GQSPVQ-LSVDEIVAAMNSEDQERQFLGMQSARKMLSRERNPPIDLMIGHGIVPICIRFLQNTNN 126
            .....| .:|:|||..:||.:.|.|....|:|||:|||||:||||.:|..|::|..:.||...::
Zfish    66 QNCQAQHWTVEEIVNGVNSNNLETQVQATQAARKLLSRERHPPIDRIISAGLIPKFVGFLSLVDS 130

  Fly   127 SMLQFEAAWALTNIASGTSDQTRCVIEHNAVPHFVALLQSKSMNLAEQAVWALGNIAGDGAAARD 191
            ..:|||||||||||||||||||..|::..|:|.|::|:.|...:::||||||||||||||:..||
Zfish   131 PPIQFEAAWALTNIASGTSDQTSAVVQGGAIPAFISLISSPHAHISEQAVWALGNIAGDGSGYRD 195

  Fly   192 IVIHHNVIDGILPLIN----NETPLSFLRNIVWLMSNLCRNKNPSPPFDQVKRLLPVLSQLLLSQ 252
            .||.|..|..:|.|:.    :..|..:|||:.|.:|||||||||:||.:.||::||.|..||...
Zfish   196 RVIKHGAIPPLLALLAVPDLSVFPAGYLRNVTWTLSNLCRNKNPAPPLEAVKQILPTLICLLQHS 260

  Fly   253 DIQVLADACWALSYVTDDDNTKIQAVVDSDAVPRLVKLLQMDEPSIIVPALRSVGNIVTGTDQQT 317
            |.:||||.|||:||:||..|.:|:.||::..|||||:||...|.||:.|:|||:||||||||:||
Zfish   261 DKEVLADTCWAISYLTDGPNDRIEVVVNAGVVPRLVQLLASGELSIVTPSLRSIGNIVTGTDEQT 325

  Fly   318 DVVIASGGLPRLGLLLQHNKSNIVKEAAWTVSNITAGNQKQIQAVIQAGIFQQLRTVLEKGDFKA 382
            ..|:.:|.||....||:|.||||.|||:||:||||||...|||.||.|||...|..||.:||:|.
Zfish   326 QAVLEAGALPMFPALLRHQKSNIQKEASWTLSNITAGRDYQIQEVINAGIVPYLVEVLRRGDYKT 390

  Fly   383 QKEAAWAVTNTTTSGTPEQIVDLIEKYKILKPFIDLLDTKDPRTIKVVQTGLSNLFALAEKLGGT 447
            ||||.|||||.|:.||.||:|.|::. .:|:|.::||.|||..||.|:...::|:|...||:|..
Zfish   391 QKEAVWAVTNYTSGGTVEQVVYLVQA-NVLEPLLNLLSTKDSTTILVILDAITNIFLAGEKIGEV 454

  Fly   448 ENLCLMVEEMGGLDKLETLQQHENEEVYKKAYAIIDTYFSNGDDEAEQELAPQEVNGALEFNATQ 512
            |.||||:||.|||||:|.||.||||.|||.:..:|:.||| |::|.::.:||:
Zfish   455 EKLCLMIEECGGLDKIEALQSHENEMVYKASLNLIEKYFS-GEEEGDECVAPE------------ 506

  Fly   513 PKAPEGGYTF 522
              |.:.||.|
Zfish   507 --ATDDGYAF 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pen	NP_477041.1	SRP1	2..517	CDD:227396	261/522 (50%)
		HEAT repeat	70..102	CDD:293787	16/31 (52%)
		armadillo repeat	108..140	CDD:293788	14/31 (45%)
		armadillo repeat	148..184	CDD:293788	17/35 (49%)
		armadillo repeat	190..225	CDD:293788	14/38 (37%)
		armadillo repeat	359..396	CDD:293788	23/36 (64%)
		armadillo repeat	402..437	CDD:293788	12/34 (35%)
kpna2	NP_001002335.1	SRP1	9..525	CDD:227396	261/522 (50%)
		armadillo repeat	112..144	CDD:293788	14/31 (45%)
		armadillo repeat	152..188	CDD:293788	17/35 (49%)
		armadillo repeat	194..233	CDD:293788	14/38 (37%)
		armadillo repeat	250..275	CDD:293788	14/24 (58%)
		armadillo repeat	283..319	CDD:293788	20/35 (57%)
		armadillo repeat	325..359	CDD:293788	18/33 (55%)
		armadillo repeat	367..403	CDD:293788	22/35 (63%)
		armadillo repeat	410..444	CDD:293788	12/34 (35%)
		armadillo repeat	452..492	CDD:293788	24/39 (62%)