Protein Alignment Pen and Kap-alpha3

DIOPT Version :10

• Sequence 1: NP_477041.1
• Gene: Pen / 34338
• FlyBaseID: FBgn0287720
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_731377.1
• Gene: Kap-alpha3 / 41158
• FlyBaseID: FBgn0027338
• Length: 514
• Species: Drosophila melanogaster
• Alignment Length: 524
• Identity: 234/524 - (44%)
• Similarity: 327/524 - (62%)
• Gaps: 12/524 - (2%)

  Fly     1 MSKADSNSRQGSYKANSINTQDSRMRRHEVTIELRKSKKEDQMFKRRNINDEDLTSPLKELNGQS 65
            |:..:.|..| ::|....:..:.|.||:|||:||||:|:|:.:.||||:.:.|..:..:|   |.
  Fly     1 MTSMEQNRLQ-NFKNKGKDQDEMRRRRNEVTVELRKNKREETILKRRNVPNLDSNTDEEE---QL 61

  Fly    66 PVQLSVDEIV-AAMNSEDQERQFLGMQSARKMLSRERNPPIDLMIGHGIVPICIRFLQNTNNSML 129
            ...:.:.::. ||.::...|:|...:|:|||:||.::||||:.:|...|:||.:..|:..|::||
  Fly    62 SSSIDLKKLAKAAADATKPEQQLAAVQAARKLLSSDKNPPINDLIQSDILPILVECLKQHNHTML 126

  Fly   130 QFEAAWALTNIASGTSDQTRCVIEHNAVPHFVALLQSKSMNLAEQAVWALGNIAGDGAAARDIVI 194
            ||||||||||||||||.||..|:...|||.|:.||.|.:.|:.||||||||||.|||...||.||
  Fly   127 QFEAAWALTNIASGTSAQTNEVVAAGAVPLFLQLLNSPAPNVCEQAVWALGNIIGDGPLLRDFVI 191

  Fly   195 HHNVIDGILPLINNETPLSFLRNIVWLMSNLCRNKNPSPPFDQVKRLLPVLSQLLLSQDIQVLAD 259
            .|.|:..:|..|..:.|::||||:.|::.||||||:|:||...:..:||.|:.|:...|..:|.|
  Fly   192 KHGVVQPLLSFIKPDIPITFLRNVTWVIVNLCRNKDPAPPTATIHEILPALNVLIHHTDTNILVD 256

  Fly   260 ACWALSYVTDDDNTKIQAVVDSDAVPRLVKLLQMDEPSIIVPALRSVGNIVTGTDQQTDVVIASG 324
            ..||:||:||..|.:||.|::|..||:|:.||...|..:...|||:|||||||:|:||.||:...
  Fly   257 TVWAISYLTDGGNDQIQMVIESGVVPKLIPLLGNSEVKVQTAALRAVGNIVTGSDEQTQVVLNYD 321

  Fly   325 GLPRLGLLLQHNKSNIVKEAAWTVSNITAGNQKQIQAVIQAGIFQQLRTVLEKGDFKAQKEAAWA 389
            .|.....||.|.|..|.|||.|.:||||||||.|:||||..|:..::...|.||:|:.|||||||
  Fly   322 ALSYFPGLLSHPKEKIRKEAVWFLSNITAGNQSQVQAVINVGLLPKIIENLSKGEFQTQKEAAWA 386

  Fly   390 VTNTTTSGTPEQIVDLIEKYKILKPFIDLLDTKDPRTIKVVQTGLSNLFALAEKLGGTENLCLMV 454
            ::|.|.||..||:..|| |..::.||.|||..:|.:.|.||..||:|:..:|:  ...|.:...:
  Fly   387 ISNLTISGNREQVFTLI-KEGVIPPFCDLLSCQDTQVINVVLDGLNNMLKVAD--SHVEAVANCI 448

  Fly   455 EEMGGLDKLETLQQHENEEVYKKAYAIIDTYFSNGDDEAEQ-ELAPQEVNGALEFNATQPKAPEG 518
            ||..||.|:|.||.|||.|:||.||.|||.||:   ||.|| .:||........|:....:....
  Fly   449 EECEGLAKIERLQSHENVEIYKLAYEIIDQYFT---DEGEQTNMAPTSDGAQYNFDPHADRLTMN 510

  Fly   519 GYTF 522
            .:.|
  Fly   511 SFNF 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pen	NP_477041.1	SRP1	2..517	CDD:227396	232/516 (45%)
		HEAT repeat	70..102	CDD:293787	10/32 (31%)
		armadillo repeat	108..140	CDD:293788	17/31 (55%)
		armadillo repeat	148..184	CDD:293788	20/35 (57%)
		armadillo repeat	190..225	CDD:293788	14/34 (41%)
		armadillo repeat	359..396	CDD:293788	18/36 (50%)
		armadillo repeat	402..437	CDD:293788	14/34 (41%)
Kap-alpha3	NP_731377.1	SRP1	8..500	CDD:227396	230/501 (46%)
		armadillo repeat	104..137	CDD:293788	17/32 (53%)
		armadillo repeat	145..181	CDD:293788	20/35 (57%)
		armadillo repeat	187..222	CDD:293788	14/34 (41%)
		armadillo repeat	239..264	CDD:293788	10/24 (42%)
		armadillo repeat	272..308	CDD:293788	17/35 (49%)
		armadillo repeat	314..348	CDD:293788	14/33 (42%)
		armadillo repeat	356..390	CDD:293788	16/33 (48%)
		armadillo repeat	399..433	CDD:293788	14/34 (41%)