Protein Alignment Pen and Kap-alpha1

DIOPT Version :10

• Sequence 1: NP_477041.1
• Gene: Pen / 34338
• FlyBaseID: FBgn0287720
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_524167.1
• Gene: Kap-alpha1 / 40160
• FlyBaseID: FBgn0024889
• Length: 543
• Species: Drosophila melanogaster
• Alignment Length: 547
• Identity: 233/547 - (42%)
• Similarity: 326/547 - (59%)
• Gaps: 35/547 - (6%)

  Fly     6 SNSRQGSYKANSINTQDSRMRRHEVTIELRKSKKEDQMFKRRNINDEDLTSPLK---ELN----- 62
            |.|.:..||..::::.:.|.||.||.|:|||:|:|.|:|||||:..|..||...   |.|
  Fly     2 SASHKQRYKNAALDSTEMRRRREEVGIQLRKNKREQQLFKRRNVVLEPATSSTSAGVESNTDNEQ 66

  Fly    63 -------------GQ------SPVQLSV--DEIVAAMNSEDQERQFLGMQSARKMLSRERNPPID 106
                         ||      |..|.||  :|::..:.|..:..|....|..||:|||:.||||:
  Fly    67 QAADMHMADSSTGGQNEEAAGSGAQPSVINEEMIQMLFSGRENEQLEATQKFRKLLSRDPNPPIE 131

  Fly   107 LMIGHGIVPICIRFLQNTNNSMLQFEAAWALTNIASGTSDQTRCVIEHNAVPHFVALLQSKSMNL 171
            .:|..||||..:.||:|:.|:.|||||||.|||||||||.||:.|||..|||.|:.||.|...::
  Fly   132 EVIQKGIVPQFVTFLRNSANATLQFEAAWTLTNIASGTSQQTKVVIEAGAVPIFIDLLSSPHDDV 196

  Fly   172 AEQAVWALGNIAGDGAAARDIVIHHNVIDGILPLINNETPLSFLRNIVWLMSNLCRNKNPSPPFD 236
            .|||||||||||||....||.::...:::.:|.:::|...::.:||.||.:|||||.|:|...|.
  Fly   197 QEQAVWALGNIAGDSPMCRDHLLGSGILEPLLHVLSNSDRITMIRNAVWTLSNLCRGKSPPADFA 261

  Fly   237 QVKRLLPVLSQLLLSQDIQVLADACWALSYVTDDDNTKIQAVVDSDAVPRLVKLLQMDEPSIIVP 301
            ::...||:|::||...|..||:|.|||:.|::|..|.|||||:|:....|||:||...:.::...
  Fly   262 KISHGLPILARLLKYTDADVLSDTCWAIGYLSDGPNDKIQAVIDAGVCRRLVELLLHPQQNVSTA 326

  Fly   302 ALRSVGNIVTGTDQQTDVVIASGGLPRLGLLLQHNKSNIVKEAAWTVSNITAGNQKQIQAVIQAG 366
            |||:|||||||.||||.|::....|..:..||......|.||:.||:|||.|||::||||:|.|.
  Fly   327 ALRAVGNIVTGDDQQTQVILGYNALTCISHLLHSTAETIKKESCWTISNIAAGNREQIQALINAN 391

  Fly   367 IFQQLRTVLEKGDFKAQKEAAWAVTNTTTSGTPEQIVDLIEKYKILKPFIDLLDTKDPRTIKVVQ 431
            ||.||..:::..:||.:||||||:||.|:|||.|||..|:: ...:.|..|.|...|...::|..
  Fly   392 IFPQLMVIMQTAEFKTRKEAAWAITNATSSGTHEQIHYLVQ-VGCVPPMCDFLTVVDSDIVQVAL 455

  Fly   432 TGLSNLFALAEKLGGTEN-LCLMVEEMGGLDKLETLQQHENEEVYKKAYAIIDTYFSNGDDEAEQ 495
            ..|.|:....||.....| ..:.:||.|||||:|.||.|||.::|.|::.||:.||  |::|.:.
  Fly   456 NALENILKAGEKFQTRPNPYAITIEECGGLDKIEYLQAHENRDIYHKSFYIIEQYF--GNEEEDS 518

  Fly   496 ELAPQEVNGALEFNATQPKAPEGGYTF 522
            .:||  |.|..:|.......|..|:.|
  Fly   519 RVAP--VAGTQQFEFDPDNMPSTGFNF 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pen	NP_477041.1	SRP1	2..517	CDD:227396	230/540 (43%)
		HEAT repeat	70..102	CDD:293787	11/33 (33%)
		armadillo repeat	108..140	CDD:293788	18/31 (58%)
		armadillo repeat	148..184	CDD:293788	21/35 (60%)
		armadillo repeat	190..225	CDD:293788	9/34 (26%)
		armadillo repeat	359..396	CDD:293788	20/36 (56%)
		armadillo repeat	402..437	CDD:293788	8/34 (24%)
Kap-alpha1	NP_524167.1	SRP1	1..543	CDD:227396	232/545 (43%)
		armadillo repeat	133..165	CDD:293788	18/31 (58%)
		armadillo repeat	173..209	CDD:293788	21/35 (60%)
		armadillo repeat	215..250	CDD:293788	9/34 (26%)
		armadillo repeat	267..292	CDD:293788	12/24 (50%)
		armadillo repeat	300..336	CDD:293788	17/35 (49%)
		armadillo repeat	342..376	CDD:293788	11/33 (33%)
		armadillo repeat	384..421	CDD:293788	20/36 (56%)
		armadillo repeat	427..461	CDD:293788	8/34 (24%)