DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pen and KPNA4

DIOPT Version :9

Sequence 1:NP_477041.1 Gene:Pen / 34338 FlyBaseID:FBgn0267727 Length:522 Species:Drosophila melanogaster
Sequence 2:NP_002259.1 Gene:KPNA4 / 3840 HGNCID:6397 Length:521 Species:Homo sapiens


Alignment Length:518 Identity:242/518 - (46%)
Similarity:339/518 - (65%) Gaps:7/518 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 NSRQGSYKANSINTQDSRMRRHEVTIELRKSKKEDQMFKRRNINDEDLTSPLKELNGQSPVQ-LS 70
            |.|..::|....:.:..|.:|:||.:||||:|:::.:.||||:..||:... .:::|...|| .|
Human     9 NQRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNVPHEDICED-SDIDGDYRVQNTS 72

  Fly    71 VDEIVAAMNSEDQERQFLGMQSARKMLSRERNPPIDLMIGHGIVPICIRFLQNTNNSMLQFEAAW 135
            ::.||...:|::|..|...:|:|||:||.:||||||.:|..||:||.:..|:..:|..|||||||
Human    73 LEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAW 137

  Fly   136 ALTNIASGTSDQTRCVIEHNAVPHFVALLQSKSMNLAEQAVWALGNIAGDGAAARDIVIHHNVID 200
            ||||||||||:||:.|::.||||.|:.||.|...|:.||||||||||.|||...||.||...|:.
Human   138 ALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVK 202

  Fly   201 GILPLINNETPLSFLRNIVWLMSNLCRNKNPSPPFDQVKRLLPVLSQLLLSQDIQVLADACWALS 265
            .:|..|:...|::||||:.|:|.||||:|:|.||.:.::.:||.|..|:...|:.:|.|..||||
Human   203 PLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALS 267

  Fly   266 YVTDDDNTKIQAVVDSDAVPRLVKLLQMDEPSIIVPALRSVGNIVTGTDQQTDVVIASGGLPRLG 330
            |:||..|.:||.|:||..||.||.||...|..:...|||:|||||||||:||.||:....|....
Human   268 YLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFP 332

  Fly   331 LLLQHNKSNIVKEAAWTVSNITAGNQKQIQAVIQAGIFQQLRTVLEKGDFKAQKEAAWAVTNTTT 395
            .||.|.|..|.|||.|.:||||||||:|:||||.|.:...:..:|:||||..|||||||::|.|.
Human   333 ALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTI 397

  Fly   396 SGTPEQIVDLIEKYKILKPFIDLLDTKDPRTIKVVQTGLSNLFALAEKLGGTENLCLMVEEMGGL 460
            ||..:|:..||:: .::.||.:||..||.:.::||..||||:..:||  ...|.:..::||.|||
Human   398 SGRKDQVAYLIQQ-NVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAE--DEAETIGNLIEECGGL 459

  Fly   461 DKLETLQQHENEEVYKKAYAIIDTYFSNGDDEAEQELAPQEV-NGALEFNATQPKAPEGGYTF 522
            :|:|.||.||||::||.||.|||.:||:.|.:.:..|.|:.: .|...||:: ...|..|:.|
Human   460 EKIEQLQNHENEDIYKLAYEIIDQFFSSDDIDEDPSLVPEAIQGGTFGFNSS-ANVPTEGFQF 521

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PenNP_477041.1 SRP1 2..517 CDD:227396 239/511 (47%)
HEAT repeat 70..102 CDD:293787 12/31 (39%)
armadillo repeat 108..140 CDD:293788 17/31 (55%)
armadillo repeat 148..184 CDD:293788 21/35 (60%)
armadillo repeat 190..225 CDD:293788 14/34 (41%)
armadillo repeat 359..396 CDD:293788 19/36 (53%)
armadillo repeat 402..437 CDD:293788 13/34 (38%)
KPNA4NP_002259.1 SRP1 11..513 CDD:227396 238/506 (47%)
Nuclear localization signal. /evidence=ECO:0000250 43..52 4/8 (50%)
ARM 1, truncated 66..106 16/39 (41%)
armadillo repeat 73..98 CDD:293788 8/24 (33%)
ARM 2 107..149 26/41 (63%)
armadillo repeat 109..142 CDD:293788 17/32 (53%)
NLS binding site (major). /evidence=ECO:0000250 137..229 52/91 (57%)
armadillo repeat 150..186 CDD:293788 21/35 (60%)
armadillo repeat 192..227 CDD:293788 14/34 (41%)
ARM 4 195..233 17/37 (46%)
ARM 5 234..278 17/43 (40%)
armadillo repeat 244..269 CDD:293788 11/24 (46%)
ARM 6 279..318 22/38 (58%)
armadillo repeat 279..311 CDD:293788 15/31 (48%)
NLS binding site (minor). /evidence=ECO:0000250 306..394 50/87 (57%)
armadillo repeat 319..355 CDD:293788 16/35 (46%)
ARM 8 361..400 20/38 (53%)
armadillo repeat 361..395 CDD:293788 17/33 (52%)
ARM 9 401..443 15/42 (36%)
armadillo repeat 404..438 CDD:293788 13/34 (38%)
ARM 10, atypical 447..485 21/37 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5064
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54553
OrthoDB 1 1.010 - - D1111872at2759
OrthoFinder 1 1.000 - - FOG0000157
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.830

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