Protein Alignment Pen and KPNA3

DIOPT Version :10

• Sequence 1: NP_477041.1
• Gene: Pen / 34338
• FlyBaseID: FBgn0287720
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_002258.2
• Gene: KPNA3 / 3839
• HGNCID: 6396
• Length: 521
• Species: Homo sapiens
• Alignment Length: 522
• Identity: 238/522 - (45%)
• Similarity: 327/522 - (62%)
• Gaps: 28/522 - (5%)

  Fly     7 NSRQGSYKANSINTQDSRMRRHEVTIELRKSKKEDQMFKRRNI------NDEDLTSPLKELNGQS 65
            |.|..|:|....:.:..|..|:|||:||||:|:::.:.|:||:      .|.|:.:..|..|
Human     9 NHRIKSFKNKGRDVETMRRHRNEVTVELRKNKRDEHLLKKRNVPQEESLEDSDVDADFKAQN--- 70

  Fly    66 PVQLSVDEIVAAMNSEDQERQFLGMQSARKMLSRERNPPIDLMIGHGIVPICIRFLQNTNNSMLQ 130
               ::::.|:....|::...|...:|:|||:||.:||||||.:|..||:||.::.|:..:|..||
Human    71 ---VTLEAILQNATSDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVKCLERDDNPSLQ 132

  Fly   131 FEAAWALTNIASGTSDQTRCVIEHNAVPHFVALLQSKSMNLAEQAVWALGNIAGDGAAARDIVIH 195
            |||||||||||||||.||:.|::.||||.|:.||:|...|:.||||||||||.|||...||.||.
Human   133 FEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLRSPHQNVCEQAVWALGNIIGDGPQCRDYVIS 197

  Fly   196 HNVIDGILPLINNETPLSFLRNIVWLMSNLCRNKNPSPPFDQVKRLLPVLSQLLLSQDIQVLADA 260
            ..|:..:|..|:...|::||||:.|::.||||||:|.||.:.|:.:||.|..|:...||.:|.|.
Human   198 LGVVKPLLSFISPSIPITFLRNVTWVIVNLCRNKDPPPPMETVQEILPALCVLIYHTDINILVDT 262

  Fly   261 CWALSYVTDDDNTKIQAVVDSDAVPRLVKLLQMDEPSIIVPALRSVGNIVTGTDQQTDVVIASGG 325
            .|||||:||..|.:||.|:||..||.||.||...|..:...|||:|||||||||:||.||:....
Human   263 VWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDV 327

  Fly   326 LPRLGLLLQHNKSNIVKEAAWTVSNITAGNQKQIQAVIQAGIFQQLRTVLEKGDFKAQKEAAWAV 390
            |.....||.|.|..|.|||.|.:||||||||:|:||||.||:...:...|.||||..|||||||:
Human   328 LSHFPNLLSHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAI 392

  Fly   391 TNTTTSGTPEQIVDLIEKYKILKPFIDLLDTKDPRTIKVVQTGLSNLFALAEKLGGTENLCLMVE 455
            :|.|.||..:|:..|::: .::.||.:||..||.:.::||..||.|:..:|.....|  :..::|
Human   393 SNLTISGRKDQVEYLVQQ-NVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGDEAST--IAEIIE 454

  Fly   456 EMGGLDKLETLQQHENEEVYKKAYAIIDTYFSNGDDEAEQELAPQEVNGALEFNATQPKAPEGGY 520
            |.|||:|:|.|||||||::||.|:.|||.|||..|.:.:..|.|:...|             |.|
Human   455 ECGGLEKIEVLQQHENEDIYKLAFEIIDQYFSGDDIDEDPCLIPEATQG-------------GTY 506

  Fly   521 TF 522
            .|
Human   507 NF 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pen	NP_477041.1	SRP1	2..517	CDD:227396	235/515 (46%)
		HEAT repeat	70..102	CDD:293787	9/31 (29%)
		armadillo repeat	108..140	CDD:293788	17/31 (55%)
		armadillo repeat	148..184	CDD:293788	21/35 (60%)
		armadillo repeat	190..225	CDD:293788	13/34 (38%)
		armadillo repeat	359..396	CDD:293788	20/36 (56%)
		armadillo repeat	402..437	CDD:293788	11/34 (32%)
KPNA3	NP_002258.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29		5/19 (26%)
		SRP1	2..521	CDD:227396	238/522 (46%)
		Nuclear localization signal. /evidence=ECO:0000250	43..52		3/8 (38%)
		ARM 1, truncated	66..106		13/45 (29%)
		armadillo repeat	73..98	CDD:293788	6/24 (25%)
		ARM 2	107..149		26/41 (63%)
		armadillo repeat	109..142	CDD:293788	17/32 (53%)
		NLS binding site (major). /evidence=ECO:0000250	137..229		51/91 (56%)
		armadillo repeat	150..186	CDD:293788	21/35 (60%)
		armadillo repeat	192..227	CDD:293788	13/34 (38%)
		ARM 4	195..233		17/37 (46%)
		ARM 5	234..278		19/43 (44%)
		armadillo repeat	244..269	CDD:293788	12/24 (50%)
		armadillo repeat	277..313	CDD:293788	19/35 (54%)
		ARM 6	279..318		22/38 (58%)
		NLS binding site (minor). /evidence=ECO:0000250	306..394		51/87 (59%)
		armadillo repeat	319..353	CDD:293788	14/33 (42%)
		ARM 8	361..400		21/38 (55%)
		armadillo repeat	361..395	CDD:293788	18/33 (55%)
		ARM 9	401..443		13/42 (31%)
		armadillo repeat	404..438	CDD:293788	11/34 (32%)
		ARM 10, atypical	447..485		21/39 (54%)