DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pen and KPNA2

DIOPT Version :9

Sequence 1:	NP_477041.1	Gene:	Pen / 34338	FlyBaseID:	FBgn0267727	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001307540.1	Gene:	KPNA2 / 3838	HGNCID:	6395	Length:	529	Species:	Homo sapiens

Alignment Length:	522	Identity:	264/522 - (50%)
Similarity:	355/522 - (68%)	Gaps:	11/522 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SRQGSYKANSINTQDSRMRRHEVTIELRKSKKEDQMFKRRNIND--EDLTSPLKE-LNGQSPVQL 69
            :|...:|....::.:.|.||.||.:||||:||:|||.||||::.  :|.||||:| .|.|..|..
Human    12 ARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNW 76

  Fly    70 SVDEIVAAMNSEDQERQFLGMQSARKMLSRERNPPIDLMIGHGIVPICIRFLQNTNNSMLQFEAA 134
            |||:||..:||.:.|.|....|:|||:||||:.||||.:|..|::|..:.||..|:.|.:|||:|
Human    77 SVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESA 141

  Fly   135 WALTNIASGTSDQTRCVIEHNAVPHFVALLQSKSMNLAEQAVWALGNIAGDGAAARDIVIHHNVI 199
            |||||||||||:||:.|::..|:|.|::||.|...:::||||||||||||||:..||:||.:..:
Human   142 WALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAV 206

  Fly   200 DGILPLI----NNETPLSFLRNIVWLMSNLCRNKNPSPPFDQVKRLLPVLSQLLLSQDIQVLADA 260
            |.:|.|:    .:.....:|||:.|.:|||||||||:||.|.|:::||.|.:||...|.:||||.
Human   207 DPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADT 271

  Fly   261 CWALSYVTDDDNTKIQAVVDSDAVPRLVKLLQMDEPSIIVPALRSVGNIVTGTDQQTDVVIASGG 325
            |||:||:||..|.:|..||.:..||:|||||...|..|:.||||::||||||||:||.|||.:|.
Human   272 CWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGA 336

  Fly   326 LPRLGLLLQHNKSNIVKEAAWTVSNITAGNQKQIQAVIQAGIFQQLRTVLEKGDFKAQKEAAWAV 390
            |.....||.:.|:||.|||.||:||||||.|.|||.|:..|:...|.:||.|.|||.||||.|||
Human   337 LAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAV 401

  Fly   391 TNTTTSGTPEQIVDLIEKYKILKPFIDLLDTKDPRTIKVVQTGLSNLFALAEKLGGTENLCLMVE 455
            ||.|:.||.||||.|:. ..|::|.::||..||.:.|.|:...:||:|..|||||.||.|.:|:|
Human   402 TNYTSGGTVEQIVYLVH-CGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIE 465

  Fly   456 EMGGLDKLETLQQHENEEVYKKAYAIIDTYFSNGDDEAEQELAPQEVNGALEFNATQPKAPEGGY 520
            |.|||||:|.||.||||.|||.:.::|:.||| .::|.:|.:.|:..:....|. .|..|| |.:
Human   466 ECGGLDKIEALQNHENESVYKASLSLIEKYFS-VEEEEDQNVVPETTSEGYTFQ-VQDGAP-GTF 527

  Fly   521 TF 522
            .|
Human   528 NF 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pen	NP_477041.1	SRP1	2..517	CDD:227396	261/515 (51%)
		HEAT repeat	70..102	CDD:293787	17/31 (55%)
		armadillo repeat	108..140	CDD:293788	15/31 (48%)
		armadillo repeat	148..184	CDD:293788	18/35 (51%)
		armadillo repeat	190..225	CDD:293788	12/38 (32%)
		armadillo repeat	359..396	CDD:293788	21/36 (58%)
		armadillo repeat	402..437	CDD:293788	12/34 (35%)
KPNA2	NP_001307540.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		2/14 (14%)
		SRP1	10..528	CDD:227396	263/519 (51%)
		IBB	10..98	CDD:280005	38/85 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..72		15/28 (54%)
		Nuclear localization signal. /evidence=ECO:0000250	45..54		7/8 (88%)
		ARM 1, truncated	71..111		19/39 (49%)
		ARM 2	112..151		21/38 (55%)
		ARM	113..238	CDD:237987	60/124 (48%)
		armadillo repeat	115..147	CDD:293788	15/31 (48%)
		NLS binding site (major). /evidence=ECO:0000250	142..238		48/95 (51%)
		armadillo repeat	155..191	CDD:293788	18/35 (51%)
		armadillo repeat	197..236	CDD:293788	12/38 (32%)
		ARM 4	200..244		18/43 (42%)
		ARM 5	246..282		19/35 (54%)
		ARM	252..364	CDD:237987	62/111 (56%)
		armadillo repeat	253..278	CDD:293788	14/24 (58%)
		ARM 6	283..322		20/38 (53%)
		armadillo repeat	286..322	CDD:293788	19/35 (54%)
		NLS binding site (minor). /evidence=ECO:0000250	315..403		52/87 (60%)
		armadillo repeat	328..362	CDD:293788	17/33 (52%)
		ARM	329..449	CDD:237987	61/120 (51%)
		ARM 8	367..409		23/41 (56%)
		armadillo repeat	370..404	CDD:293788	19/33 (58%)
		ARM 9	410..456		20/46 (43%)
		armadillo repeat	413..447	CDD:293788	12/34 (35%)
		ARM 10, atypical	457..496		22/38 (58%)
		Arm_3	458..508	CDD:292804	26/50 (52%)
		armadillo repeat	460..495	CDD:293788	20/34 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9910
eggNOG	1	0.900	-	-		E1_COG5064
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1708
Inparanoid	1	1.050	492	1.000	Inparanoid score	I1420
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54553
OrthoDB	1	1.010	-	-		D1111872at2759
OrthoFinder	1	1.000	-	-		FOG0000157
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100442
Panther	1	1.100	-	-	LDO	PTHR23316
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4606
SonicParanoid	1	1.000	-	-		X4000
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870