DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pen and Kpna7

DIOPT Version :9

Sequence 1:	NP_477041.1	Gene:	Pen / 34338	FlyBaseID:	FBgn0267727	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001334460.1	Gene:	Kpna7 / 381686	MGIID:	2141165	Length:	520	Species:	Mus musculus

Alignment Length:	518	Identity:	203/518 - (39%)
Similarity:	302/518 - (58%)	Gaps:	35/518 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SKADSNSRQGSYKANSINTQDSRMRRHEVTIELRKSKKEDQMFKRRNIN--DEDLTSP--LKELN 62
            ||| ...|..:||.........|.:|...:::|||::|::|:.|||||:  ..|:.|.  :||:|
Mouse     4 SKA-PKERLKNYKYRGKEMSLPRQQRIASSLQLRKTRKDEQVLKRRNIDLFSSDMVSQALVKEVN 67

  Fly    63 GQSPVQLSVDEIVAAMNSEDQERQFLGMQSARKMLSRERNPPIDLMIGHGIVPICIRFLQNTNNS 127
                  .::|:|:.|:||.|....|...::||:|:|:|..||::|:|..|::|..:.||:.|.:.
Mouse    68 ------FTLDDIIQAVNSSDPILHFRATRAAREMISQENTPPLNLIIEAGLIPKLVDFLKATPHP 126

  Fly   128 MLQFEAAWALTNIASGTSDQTRCVIEHNAVPHFVALLQSKSMNLAEQAVWALGNI---------- 182
            .|||||||.|||||||||:|||.|::..|:...:.||.|..:.::||||||||||
Mouse   127 KLQFEAAWVLTNIASGTSEQTRAVVKEGAIQPLIELLCSPHLTVSEQAVWALGNIADRKMPDTQV 191

  Fly   183 -----------AGDGAAARDIVIHHNVIDGILPLINNETPLSFLRNIVWLMSNLCRNKNPSPPFD 236
                       |||.|..||.||.:|.|..::.||:...|::|||||.|.:|||||||:|.|...
Mouse   192 QIFTPSTREAKAGDCAEFRDCVISNNAIPHLINLISKGIPITFLRNISWTLSNLCRNKDPYPSES 256

  Fly   237 QVKRLLPVLSQLLLSQDIQVLADACWALSYVTDDDNTKIQAVVDSDAVPRLVKLLQMDEPSIIVP 301
            .|:::||.|.||||.:|.::|||.||||||:|......|..||.:..:||||:|:...|.||.:|
Mouse   257 AVRQMLPPLCQLLLHRDNEILADTCWALSYLTKGGKEYIHHVVTTGILPRLVELMTSSELSISIP 321

  Fly   302 ALRSVGNIVTGTDQQTDVVIASGGLPRLGLLLQHNKSNIVKEAAWTVSNITAGNQKQIQAVIQAG 366
            .|.::||||.|||:||.:.|.:|.|..||.:|:|.|::|...||||:||:.||.:.|::.:: ..
Mouse   322 CLHTIGNIVAGTDEQTQMAIDAGMLKVLGQVLKHPKTSIQVLAAWTMSNVAAGPRHQVEQLL-CN 385

  Fly   367 IFQQLRTVLEKGDFKAQKEAAWAVTNTTTSGTPEQIVDLIEKYKILKPFIDLLDTKDPRTIKVVQ 431
            :...|..:|...:.|.|||....|.|..|..:.:|:. |:....||:|.:.||...|...:.:|.
Mouse   386 LLPILVDLLRNAELKVQKEVVCTVINIATGASQDQLT-LLAHSGILEPMLSLLSAPDLEVVIIVL 449

  Fly   432 TGLSNLFALAEKLGGTENLCLMVEEMGGLDKLETLQQHENEEVYKKAYAIIDTYF-SNGDDEA 493
            ..:|.|....:.|...:.|...:|:.||.:|:|.||.|.|..:...|..||:.|| .:||.::
Mouse   450 DIISYLLQHIDNLQEKKRLYFQIEKFGGFEKIECLQHHHNISISNSALDIIEKYFCEDGDGDS 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pen	NP_477041.1	SRP1	2..517	CDD:227396	203/518 (39%)
		HEAT repeat	70..102	CDD:293787	12/31 (39%)
		armadillo repeat	108..140	CDD:293788	15/31 (48%)
		armadillo repeat	148..184	CDD:293788	17/56 (30%)
		armadillo repeat	190..225	CDD:293788	16/34 (47%)
		armadillo repeat	359..396	CDD:293788	8/36 (22%)
		armadillo repeat	402..437	CDD:293788	9/34 (26%)
Kpna7	NP_001334460.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5064
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54553
OrthoDB	1	1.010	-	-		D1111872at2759
OrthoFinder	1	1.000	-	-		FOG0000157
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23316
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.890