DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pen and kpna4

DIOPT Version :9

Sequence 1:	NP_477041.1	Gene:	Pen / 34338	FlyBaseID:	FBgn0267727	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_958462.1	Gene:	kpna4 / 327373	ZFINID:	ZDB-GENE-030131-5584	Length:	521	Species:	Danio rerio

Alignment Length:	526	Identity:	241/526 - (45%)
Similarity:	339/526 - (64%)	Gaps:	9/526 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKADSNSRQ--GSYKANSINTQDSRMRRHEVTIELRKSKKEDQMFKRRNINDEDLTSPLKELNG 63
            ||.::...:|  .::|....:.:..|.:|.||.:||||:|:::.:.||||:..||:... .:.:|
Zfish     1 MSDSEKLDKQRLKNFKNKGRDLETMRRQRTEVVVELRKNKRDEHLLKRRNVPHEDICDD-SDADG 64

  Fly    64 QSPVQ-LSVDEIVAAMNSEDQERQFLGMQSARKMLSRERNPPIDLMIGHGIVPICIRFLQNTNNS 127
            ....| .|::.||....|::|..|...:|:|||:||.:||||||.:|..||:||.:..|...:|.
Zfish    65 DFRSQNTSLEAIVQNATSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLDRDDNP 129

  Fly   128 MLQFEAAWALTNIASGTSDQTRCVIEHNAVPHFVALLQSKSMNLAEQAVWALGNIAGDGAAARDI 192
            .|||||||||||||||||:||:.|::.||||.|:.||.|...|:.||||||||||.|||...||.
Zfish   130 SLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDY 194

  Fly   193 VIHHNVIDGILPLINNETPLSFLRNIVWLMSNLCRNKNPSPPFDQVKRLLPVLSQLLLSQDIQVL 257
            ||...|:..:|..|:...|::||||:.|:|.||||:|:|.||.:.::.:||.|..|:...|:.:|
Zfish   195 VISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNIL 259

  Fly   258 ADACWALSYVTDDDNTKIQAVVDSDAVPRLVKLLQMDEPSIIVPALRSVGNIVTGTDQQTDVVIA 322
            .|..|||||:||..|.:||.|:||..||.||.||...|..:...|||:|||||||||:||.||:.
Zfish   260 VDTVWALSYLTDAGNEQIQMVIDSGIVPYLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLN 324

  Fly   323 SGGLPRLGLLLQHNKSNIVKEAAWTVSNITAGNQKQIQAVIQAGIFQQLRTVLEKGDFKAQKEAA 387
            ...|.....||.|.|..|.|||.|.:||||||||:|:||||.|.:...:..:|:||||..|||||
Zfish   325 CDALGHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIILLLDKGDFGTQKEAA 389

  Fly   388 WAVTNTTTSGTPEQIVDLIEKYKILKPFIDLLDTKDPRTIKVVQTGLSNLFALAEKLGGTENLCL 452
            ||::|.|.||..:|:..||:: :::.||.:||..||.:.::||..||||:..:|:  ...|.:..
Zfish   390 WAISNLTISGRKDQVAYLIQQ-QVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAD--DEAETVAN 451

  Fly   453 MVEEMGGLDKLETLQQHENEEVYKKAYAIIDTYFSNGDDEAEQELAPQEV-NGALEFNATQPKAP 516
            ::||.|||:|:|.||.||||::||.||.|||.:||:.|.:.:..|.|:.: .|...||:: ...|
Zfish   452 LIEECGGLEKIEQLQNHENEDIYKLAYEIIDQFFSSDDIDEDSNLVPEAIQGGTYSFNSS-TNVP 515

  Fly   517 EGGYTF 522
            ..|:.|
Zfish   516 AEGFQF 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pen	NP_477041.1	SRP1	2..517	CDD:227396	237/518 (46%)
		HEAT repeat	70..102	CDD:293787	12/31 (39%)
		armadillo repeat	108..140	CDD:293788	17/31 (55%)
		armadillo repeat	148..184	CDD:293788	21/35 (60%)
		armadillo repeat	190..225	CDD:293788	14/34 (41%)
		armadillo repeat	359..396	CDD:293788	19/36 (53%)
		armadillo repeat	402..437	CDD:293788	13/34 (38%)
kpna4	NP_958462.1	SRP1	2..520	CDD:227396	239/522 (46%)
		IBB	10..93	CDD:280005	25/83 (30%)
		armadillo repeat	73..98	CDD:293788	8/24 (33%)
		ARM	108..229	CDD:237987	66/120 (55%)
		armadillo repeat	109..142	CDD:293788	17/32 (53%)
		armadillo repeat	150..186	CDD:293788	21/35 (60%)
		armadillo repeat	192..227	CDD:293788	14/34 (41%)
		ARM	242..355	CDD:237987	56/112 (50%)
		armadillo repeat	244..269	CDD:293788	11/24 (46%)
		armadillo repeat	279..311	CDD:293788	15/31 (48%)
		armadillo repeat	319..355	CDD:293788	16/35 (46%)
		armadillo repeat	361..395	CDD:293788	17/33 (52%)
		ARM	362..486	CDD:237987	58/126 (46%)
		armadillo repeat	404..438	CDD:293788	13/34 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54553
OrthoDB	1	1.010	-	-		D1111872at2759
OrthoFinder	1	1.000	-	-		FOG0000157
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.930