Protein Alignment Pen and Kpna5

DIOPT Version :10

• Sequence 1: NP_477041.1
• Gene: Pen / 34338
• FlyBaseID: FBgn0287720
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_001020284.2
• Gene: Kpna5 / 294392
• RGDID: 1561324
• Length: 539
• Species: Rattus norvegicus
• Alignment Length: 539
• Identity: 250/539 - (46%)
• Similarity: 336/539 - (62%)
• Gaps: 27/539 - (5%)

  Fly     2 SKADSNSRQGSYKANSINTQDSRMRRHEVTIELRKSKKEDQMFKRRNI----NDE-DLTSPLKEL 61
            |....|.|..|||..::|.|:.|.||.|..|:|||.|:|:|:|||||:    ||: .|.||:::.
  Rat     6 SPGKDNYRMKSYKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVSLPRNDDCMLESPIQDP 70

  Fly    62 NGQSPVQLSVDEIVAA-----MNSEDQERQFLGMQSARKMLSRERNPPIDLMIGH-GIVPICIRF 120
            :..|.|.:..::::.|     :.|.:.|:|....|..||:||:|.|||||.:|.. |:|...::|
  Rat    71 DVSSTVPIPEEDMITADMIQMIFSNNAEQQLTATQKFRKLLSKEPNPPIDQVIQKPGVVQRFVKF 135

  Fly   121 LQNTNNSMLQFEAAWALTNIASGTSDQTRCVIEHNAVPHFVALLQSKSMNLAEQAVWALGNIAGD 185
            |:...|..||||||||||||||||...|:.|||..|||.|:.||.|:..::.|||||||||||||
  Rat   136 LERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIRLLTSEHEDVQEQAVWALGNIAGD 200

  Fly   186 GAAARDIVIHHNVIDGILPLINNETPLSFLRNIVWLMSNLCRNKNPSPPFDQVKRLLPVLSQLLL 250
            .|..||.|::..::..:|.|:.|...|:..||.||.:|||||.|||.|.|.:|...|.|||:||.
  Rat   201 NAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCLNVLSRLLF 265

  Fly   251 SQDIQVLADACWALSYVTDDDNTKIQAVVDSDAVPRLVKLLQMDEPSIIVPALRSVGNIVTGTDQ 315
            |.|..||||.||||||::|..|.|||.|:||....|||:||..::..::.||||:|||||||.|.
  Rat   266 SSDPDVLADVCWALSYLSDGPNDKIQVVIDSGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDI 330

  Fly   316 QTDVVIASGGLPRLGLLLQHNKSNIVKEAAWTVSNITAGNQKQIQAVIQAGIFQQLRTVLEKGDF 380
            ||.|::....||.|..||...|.::.|||.||:|||||||:.||||||...||..|..||:|.:|
  Rat   331 QTQVILNCSALPCLLHLLGSPKESVRKEACWTISNITAGNRMQIQAVIDGSIFPVLIEVLQKAEF 395

  Fly   381 KAQKEAAWAVTNTTTSGTPEQIVDLIEKYKI----LKPFIDLLDTKDPRTIKVVQTGLSNLFALA 441
            :.:||||||:||.|:.|.||||     :|.:    :||..|||...|.:.::|...||.|:..|.
  Rat   396 RTRKEAAWAITNATSGGAPEQI-----RYLVTLGCIKPLCDLLTVMDSKIVQVALNGLENILRLG 455

  Fly   442 EKLG-----GTENLCLMVEEMGGLDKLETLQQHENEEVYKKAYAIIDTYFSNGDDEAEQELAPQE 501
            |:..     |....|.::||..||||:|.||.|||:|:|:||:.:|:.||  |.:|.:..|.||.
  Rat   456 ERESKQNGVGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIERYF--GVEEDDPSLVPQV 518

  Fly   502 VNGALEFNATQPKAPEGGY 520
            .....:|...|.:||..|:
  Rat   519 DEQQRQFLFQQCEAPGEGF 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pen	NP_477041.1	SRP1	2..517	CDD:227396	248/534 (46%)
		HEAT repeat	70..102	CDD:293787	10/36 (28%)
		armadillo repeat	108..140	CDD:293788	16/32 (50%)
		armadillo repeat	148..184	CDD:293788	21/35 (60%)
		armadillo repeat	190..225	CDD:293788	12/34 (35%)
		armadillo repeat	359..396	CDD:293788	21/36 (58%)
		armadillo repeat	402..437	CDD:293788	11/38 (29%)
Kpna5	NP_001020284.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..38		13/31 (42%)
		SRP1	36..528	CDD:227396	234/498 (47%)
		Nuclear localization signal. /evidence=ECO:0000250	45..54		6/8 (75%)
		ARM 1, truncated	76..118		12/41 (29%)
		ARM 2	119..162		24/42 (57%)
		armadillo repeat	122..155	CDD:293788	16/32 (50%)
		NLS binding site (major). /evidence=ECO:0000250	150..242		49/91 (54%)
		armadillo repeat	163..199	CDD:293788	21/35 (60%)
		armadillo repeat	205..240	CDD:293788	12/34 (35%)
		ARM 4	208..246		15/37 (41%)
		ARM 5	247..291		24/43 (56%)
		armadillo repeat	257..282	CDD:293788	17/24 (71%)
		armadillo repeat	290..326	CDD:293788	18/35 (51%)
		ARM 6	292..331		20/38 (53%)
		NLS binding site (minor). /evidence=ECO:0000250	319..407		49/87 (56%)
		armadillo repeat	332..366	CDD:293788	14/33 (42%)
		ARM 8	374..413		21/38 (55%)
		armadillo repeat	374..410	CDD:293788	20/35 (57%)
		ARM 9	414..456		16/46 (35%)
		armadillo repeat	417..451	CDD:293788	11/38 (29%)
		ARM 10, atypical	460..505		19/44 (43%)