DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pen and Kpna1

DIOPT Version :9

Sequence 1:	NP_477041.1	Gene:	Pen / 34338	FlyBaseID:	FBgn0267727	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_942021.2	Gene:	Kpna1 / 288064	RGDID:	735064	Length:	538	Species:	Rattus norvegicus

Alignment Length:	532	Identity:	236/532 - (44%)
Similarity:	326/532 - (61%)	Gaps:	21/532 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NSRQGSYKANSINTQDSRMRRHEVTIELRKSKKEDQMFKRRNI------NDEDLTSP----LKEL 61
            |.|..|||..|:|..:.|.||.|..::|||.|:|:|:|||||:      .:|::.|.    ..::
  Rat     8 NFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEEVMSDGGFHEAQI 72

  Fly    62 NG--QSPVQLSVDEIVAAMNSEDQERQFLGMQSARKMLSRERNPPIDLMIG-HGIVPICIRFLQN 123
            |.  .:|..:...::...:.|...|:|....|..||:||:|.|||||.:|. .|:|...:.||:.
  Rat    73 NNMEMAPGGVITSDMTEMIFSNSPEQQLSATQKFRKLLSKEPNPPIDEVINTPGVVARFVEFLKR 137

  Fly   124 TNNSMLQFEAAWALTNIASGTSDQTRCVIEHNAVPHFVALLQSKSMNLAEQAVWALGNIAGDGAA 188
            ..|..||||:||.|||||||.|.|||.||:..|||.|:.||.|:..::.|||||||||||||...
  Rat   138 KENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTM 202

  Fly   189 ARDIVIHHNVIDGILPLINNETPLSFLRNIVWLMSNLCRNKNPSPPFDQVKRLLPVLSQLLLSQD 253
            .||.|:..|::..:|.|.:.:..|:..||.||.:|||||.|:|.|.|.:|...|.|||.||...|
  Rat   203 CRDYVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSD 267

  Fly   254 IQVLADACWALSYVTDDDNTKIQAVVDSDAVPRLVKLLQMDEPSIIVPALRSVGNIVTGTDQQTD 318
            ..|||||||||||::|..|.|||||:|:....|||:||..::..::.||||:|||||||.|.||.
  Rat   268 TDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQ 332

  Fly   319 VVIASGGLPRLGLLLQHNKSNIVKEAAWTVSNITAGNQKQIQAVIQAGIFQQLRTVLEKGDFKAQ 383
            |::....|..|..||...|.:|.|||.||:|||||||:.|||.||.|.:|..|.::|:..:|:.:
  Rat   333 VILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANMFPALISILQTAEFRTR 397

  Fly   384 KEAAWAVTNTTTSGTPEQIVDLIEKYKILKPFIDLLDTKDPRTIKVVQTGLSNLFALAEKL---- 444
            ||||||:||.|:.|:.|||..|:| ...:||..|||...|.:.::|...||.|:..|.|:.
  Rat   398 KEAAWAITNATSGGSAEQIKYLVE-LGCIKPLCDLLTVMDAKIVQVALNGLENILRLGEQEAKRN 461

  Fly   445 -GGTENLCLMVEEMGGLDKLETLQQHENEEVYKKAYAIIDTYFSNGDDEAEQELAPQEVNGALEF 508
             .|....|.::||..||||:|.||.|||:|:|:||:.:|:.||  |.::.:..:|||......::
  Rat   462 GSGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYF--GTEDEDSSIAPQVDLSQQQY 524

  Fly   509 NATQPKAPEGGY 520
            ...|.:||..|:
  Rat   525 IFQQCEAPMEGF 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pen	NP_477041.1	SRP1	2..517	CDD:227396	234/527 (44%)
		HEAT repeat	70..102	CDD:293787	9/31 (29%)
		armadillo repeat	108..140	CDD:293788	14/32 (44%)
		armadillo repeat	148..184	CDD:293788	21/35 (60%)
		armadillo repeat	190..225	CDD:293788	12/34 (35%)
		armadillo repeat	359..396	CDD:293788	18/36 (50%)
		armadillo repeat	402..437	CDD:293788	12/34 (35%)
Kpna1	NP_942021.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		15/32 (47%)
		SRP1	33..516	CDD:227396	219/485 (45%)
		Nuclear localization signal. /evidence=ECO:0000250	42..51		6/8 (75%)
		ARM 1, truncated	77..117		11/39 (28%)
		ARM 2. /evidence=ECO:0000305	118..161		22/42 (52%)
		armadillo repeat	128..154	CDD:293788	12/25 (48%)
		NLS binding site (major). /evidence=ECO:0000250	149..241		48/91 (53%)
		armadillo repeat	162..198	CDD:293788	21/35 (60%)
		armadillo repeat	204..239	CDD:293788	12/34 (35%)
		ARM 4. /evidence=ECO:0000305	207..245		15/37 (41%)
		Binding to RAG1	245..437		98/192 (51%)
		armadillo repeat	256..281	CDD:293788	17/24 (71%)
		armadillo repeat	289..325	CDD:293788	18/35 (51%)
		NLS binding site (minor). /evidence=ECO:0000250	318..406		46/87 (53%)
		armadillo repeat	373..409	CDD:293788	17/35 (49%)
		ARM 9. /evidence=ECO:0000305	413..457		17/44 (39%)
		armadillo repeat	416..450	CDD:293788	12/34 (35%)
		ARM 10, atypical	460..504		19/43 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54553
OrthoDB	1	1.010	-	-		D1111872at2759
OrthoFinder	1	1.000	-	-		FOG0000157
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100442
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.830