DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pen and imp1

DIOPT Version :9

Sequence 1:	NP_477041.1	Gene:	Pen / 34338	FlyBaseID:	FBgn0267727	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_596632.1	Gene:	imp1 / 2539928	PomBaseID:	SPBC1604.08c	Length:	539	Species:	Schizosaccharomyces pombe

Alignment Length:	539	Identity:	233/539 - (43%)
Similarity:	342/539 - (63%)	Gaps:	33/539 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ADSNSR---QGSYKANSINTQDSRMRRHEVTIELRKSKKEDQMFKRRNIN---DEDLTSPLKELN 62
            :|..||   :|.:||:.:     |.:|.|..||:||.|:|:.:.||||:|   ..|:  .::|..
pombe     7 SDRRSRFKSKGVFKADEL-----RRQREEQQIEIRKQKREESLNKRRNLNAVLQNDI--DVEEEA 64

  Fly    63 GQSPVQLS---VDE---IVAAMNSEDQERQFLGMQSARKMLSRERNPPIDLMIGHGIVPICIRFL 121
            .||.||:.   .||   :.|.:.|:|.|.|...:...||.||:|.:||||.:|..|:|...::||
pombe    65 DQSQVQMEQQMKDEFPKLTADVMSDDIELQLGAVTKFRKYLSKETHPPIDQVIACGVVDRFVQFL 129

  Fly   122 QNTNNSMLQFEAAWALTNIASGTSDQTRCVIEHNAVPHFVALLQSKSMNLAEQAVWALGNIAGDG 186
            ::.:: :||||||||||||||||:||||.|::..|||.|:.||.|...::.||.||||||||||.
pombe   130 ESEHH-LLQFEAAWALTNIASGTTDQTRIVVDSGAVPRFIQLLSSPEKDVREQVVWALGNIAGDS 193

  Fly   187 AAARDIVIHHNVIDGILPLI-NNETPLSFLRNIVWLMSNLCRNKNPSPPFDQVKRLLPVLSQLLL 250
            :|.||.|:.:.|:..:|.:: ::.:.:|.|||..|.:|||||.|||.|.:..:...:|:|::||.
pombe   194 SACRDYVLGNGVLQPLLNILQSSASDVSMLRNATWTLSNLCRGKNPPPNWSTISVAVPILAKLLY 258

  Fly   251 SQDIQVLADACWALSYVTDDDNTKIQAVVDSDAVPRLVKLLQMDEPSIIVPALRSVGNIVTGTDQ 315
            |:|::::.|||||:||::|..|.||.|::|....||||:||.....:|..||||||||||||||.
pombe   259 SEDVEIIVDACWAISYLSDGPNEKIGAILDVGCAPRLVELLSSPSVNIQTPALRSVGNIVTGTDA 323

  Fly   316 QTDVVIASGGLPRLGLLLQHNKSNIVKEAAWTVSNITAGNQKQIQAVIQAGIFQQLRTVLEKGDF 380
            ||.::|..|.|.....||.|.|.||.|||.||:|||||||.:||||:|::.:...|..:|...|:
pombe   324 QTQIIIDCGALNAFPSLLSHQKENIRKEACWTISNITAGNTQQIQAIIESNLIPPLVHLLSYADY 388

  Fly   381 KAQKEAAWAVTNTTTS--GTPEQIVDLIEKYKILKPFIDLLDTKDPRTIKVVQTGLSNLFALAE- 442
            |.:|||.||::|.|:.  |.|:||..|:.: .::||..|:|:..|.:.|:|....:.|:..:.|
pombe   389 KTKKEACWAISNATSGGLGQPDQIRYLVSQ-GVIKPLCDMLNGSDNKIIQVALDAIENILKVGEM 452

  Fly   443 -KLGGTENL---CLMVEEMGGLDKLETLQQHENEEVYKKAYAIIDTYFSNGDDEAEQELAPQEVN 503
             :....||:   .:.|||.||:|.:..||...|.::|.|||:||:.|||  |::|.::|||:..|
pombe   453 DRTMDLENINQYAVYVEEAGGMDMIHDLQSSGNNDIYLKAYSIIEKYFS--DEDAVEDLAPETEN 515

  Fly   504 GALEFNATQPKAPEGGYTF 522
            ||..| ...|:| :|.:.|
pombe   516 GAFTF-GNGPQA-QGEFKF 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pen	NP_477041.1	SRP1	2..517	CDD:227396	231/532 (43%)
		HEAT repeat	70..102	CDD:293787	12/37 (32%)
		armadillo repeat	108..140	CDD:293788	15/31 (48%)
		armadillo repeat	148..184	CDD:293788	19/35 (54%)
		armadillo repeat	190..225	CDD:293788	11/35 (31%)
		armadillo repeat	359..396	CDD:293788	15/36 (42%)
		armadillo repeat	402..437	CDD:293788	9/34 (26%)
imp1	NP_596632.1	SRP1	1..531	CDD:227396	232/536 (43%)
		IBB	9..99	CDD:280005	32/96 (33%)
		ARM	114..235	CDD:237987	60/121 (50%)
		armadillo repeat	115..147	CDD:293788	15/32 (47%)
		armadillo repeat	155..191	CDD:293788	19/35 (54%)
		armadillo repeat	197..233	CDD:293788	11/35 (31%)
		ARM	249..361	CDD:237987	59/111 (53%)
		armadillo repeat	250..275	CDD:293788	12/24 (50%)
		armadillo repeat	285..317	CDD:293788	16/31 (52%)
		ARM	326..446	CDD:237987	49/120 (41%)
		armadillo repeat	327..359	CDD:293788	15/31 (48%)
		armadillo repeat	367..403	CDD:293788	14/35 (40%)
		armadillo repeat	412..446	CDD:293788	9/34 (26%)
		Arm_3	462..508	CDD:292804	20/47 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5064
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54553
OrthoFinder	1	1.000	-	-		FOG0000157
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100442
Panther	1	1.100	-	-	O	PTHR23316
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820