DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pen and cut15

DIOPT Version :9

Sequence 1:	NP_477041.1	Gene:	Pen / 34338	FlyBaseID:	FBgn0267727	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_587868.1	Gene:	cut15 / 2539426	PomBaseID:	SPCC962.03c	Length:	542	Species:	Schizosaccharomyces pombe

Alignment Length:	528	Identity:	227/528 - (42%)
Similarity:	320/528 - (60%)	Gaps:	21/528 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RQGSYKA-NSINTQDSRMRRHEVTIELRKSKKEDQMFKRRNIND----EDLTSPL-KELNGQSPV 67
            |:.:||. .:....:.|.||....||:||.|:|:.:.||||:.|    .:.|.|| ::......:
pombe    12 RRQNYKGKGTFQADELRRRRETQQIEIRKQKREENLNKRRNLVDVQEPAEETIPLEQDKENDLEL 76

  Fly    68 QLSVDEIVAAMNSEDQERQFLGMQSARKMLSRERNPPIDLMIGHGIVPICIRFLQNTNNSMLQFE 132
            :|.:.:::.|:.|:|.|.|.......||.||:|.||||..:|..|:||..:.||.:.|| :|:||
pombe    77 ELQLPDLLKALYSDDIEAQIQATAKFRKALSKETNPPIQKVIDAGVVPRFVEFLSHENN-LLKFE 140

  Fly   133 AAWALTNIASGTSDQTRCVIEHNAVPHFVALLQSKSMNLAEQAVWALGNIAGDGAAARDIVIHHN 197
            |:|||||:|||:|:||..|:|.||||.||:||.|...::.|||||||||||||....||.|:...
pombe   141 ASWALTNVASGSSNQTHVVVEANAVPVFVSLLSSSEQDVREQAVWALGNIAGDSPMCRDHVLQCG 205

  Fly   198 VIDGILPLINNETPLSFLRNIVWLMSNLCRNKNPSPPFDQVKRLLPVLSQLLLSQDIQVLADACW 262
            |::.:|.:|.:...||.|||..|.:||:||.|||.|.::.:.:::||||:|:.:.|..||.||.|
pombe   206 VLEPLLNIIESNRRLSMLRNSTWTLSNMCRGKNPQPDWNSISQVIPVLSKLIYTLDEDVLVDALW 270

  Fly   263 ALSYVTDDDNTKIQAVVDSDAVPRLVKLLQMDEPSIIVPALRSVGNIVTGTDQQTDVVIASGGLP 327
            |:||::|..|.||||::|:....|||:||......:..||||||||||||.|.||.|:|..|.|.
pombe   271 AISYLSDGANEKIQAIIDAGIPRRLVELLMHPSAQVQTPALRSVGNIVTGDDVQTQVIINCGALS 335

  Fly   328 RLGLLLQHNKSNIVKEAAWTVSNITAGNQKQIQAVIQAGIFQQLRTVLEKGDFKAQKEAAWAVTN 392
            .|..||...:..:.|||.||:|||||||..|||.||:|.|...|..:|...|||.||||.||::|
pombe   336 ALLSLLSSPRDGVRKEACWTISNITAGNSSQIQYVIEANIIPPLIHLLTTADFKIQKEACWAISN 400

  Fly   393 TTTSGT--PEQIVDLIEKYKILKPFIDLLDTKDPRTIKVVQTGLSNLFALAEKLGGTEN------ 449
            .|:.|.  |:||..|:|:..| ||..:||..:|.:.|:|...|:.|:..:.| |....|
pombe   401 ATSGGARRPDQIRYLVEQGAI-KPLCNLLACQDNKIIQVALDGIENILRVGE-LDRANNPDKINL 463

  Fly   450 LCLMVEEMGGLDKLETLQQHENEEVYKKAYAIIDTYFSNGDDEAEQELAPQEVNGALEFNATQPK 514
            ..:.||:.||:|.:...|...|.|:|:|||.||:.:|  |:::..:||.|:.|.....|..||
pombe   464 YAVYVEDAGGMDLIHECQNSSNSEIYQKAYNIIEKFF--GEEDEIEELEPETVGDTFTFGTTQ-- 524

  Fly   515 APEGGYTF 522
            .|.|.:.|
pombe   525 EPAGDFQF 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pen	NP_477041.1	SRP1	2..517	CDD:227396	224/521 (43%)
		HEAT repeat	70..102	CDD:293787	10/31 (32%)
		armadillo repeat	108..140	CDD:293788	16/31 (52%)
		armadillo repeat	148..184	CDD:293788	22/35 (63%)
		armadillo repeat	190..225	CDD:293788	13/34 (38%)
		armadillo repeat	359..396	CDD:293788	19/36 (53%)
		armadillo repeat	402..437	CDD:293788	12/34 (35%)
cut15	NP_587868.1	SRP1	3..531	CDD:227396	226/525 (43%)
		IBB	8..99	CDD:280005	26/86 (30%)
		armadillo repeat	73..106	CDD:293788	8/32 (25%)
		ARM	115..235	CDD:237987	61/120 (51%)
		armadillo repeat	116..148	CDD:293788	16/32 (50%)
		armadillo repeat	156..192	CDD:293788	22/35 (63%)
		armadillo repeat	198..233	CDD:293788	13/34 (38%)
		ARM	199..319	CDD:237987	54/119 (45%)
		armadillo repeat	250..275	CDD:293788	13/24 (54%)
		armadillo repeat	283..361	CDD:293788	39/77 (51%)
		ARM	344..446	CDD:237987	47/102 (46%)
		armadillo repeat	367..400	CDD:293788	17/32 (53%)
		armadillo repeat	412..446	CDD:293788	12/34 (35%)
		Arm_3	462..>501	CDD:292804	15/40 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5064
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54553
OrthoFinder	1	1.000	-	-		FOG0000157
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100442
Panther	1	1.100	-	-	O	PTHR23316
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820