Protein Alignment Pen and F53B2.5

DIOPT Version :9

• Sequence 1: NP_477041.1
• Gene: Pen / 34338
• FlyBaseID: FBgn0267727
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_502400.2
• Gene: F53B2.5 / 178204
• WormBaseID: WBGene00009956
• Length: 476
• Species: Caenorhabditis elegans
• Alignment Length: 546
• Identity: 116/546 - (21%)
• Similarity: 215/546 - (39%)
• Gaps: 131/546 - (23%)

  Fly     1 MSKADSNSRQGSYKANSINTQDSRMRRHEVT--IELRKSKKEDQM------FKRRNINDEDLTS- 56
            |.|:...::|      .:|:|..:....:::  |.:.:|....|:      |::...|..||::
 Worm     1 MVKSTKKAKQ------EMNSQPEQSATFDISFIISMLESSCRIQLSTALHFFRKAFANQSDLSNI 59

  Fly    57 PLKELNGQSPVQLSVDEIVAAMNSEDQERQFLGMQSARKMLSRERNPPIDLMIGHGIVPICIRFL 121
            .|||                         ||.| :....:|:..||..:|:
 Worm    60 ALKE-------------------------QFYG-RIKNGVLNALRNQTLDI-------------- 84

  Fly   122 QNTNNSMLQFEAAWALTNIASGTSDQTRCVIEHNAVPHFVALLQSKSMNLAEQAVWALGNIAGDG 186
                :|  :..|.|.:||:...:.:.|...:..|.:...:.|::|::..|:.|.|||:.|||.|.
 Worm    85 ----DS--EVNAVWIITNMCCISQEVTHLFVNSNCLDILIKLVRSQNARLSSQTVWAIANIAADC 143

  Fly   187 AA--------------ARDIVIHHNVIDGILPLINNETPLSFLRNIVWLMSNLCRNKNPSPPFDQ 237
            ::              ||::...:.:.|            :..|.::|.::|:......:.|...
 Worm   144 SSCKLKCRSPKLLKILARNLQTSYKLDD------------ADRRQLIWCVNNIFSGGRTTMPSPV 196

  Fly   238 VKRLLPVLSQLLLSQDIQVLADAC-----WALSYVTDD--DNTKIQAVVDSDAVPR--LVKLLQM 293
            .:.|:..||.:||..| .|....|     |.|:.:.|:  |.|:|..::..:.|..  |.|.:..
 Worm   197 ARSLICALSAILLDTD-AVDNMGCGSMILWTLANLVDNSLDTTRIDMLLSQNYVVEHILEKFIDQ 260

  Fly   294 DEPSIIVPALRSVGNIVTGTDQQTDVVIASGGLPRLGLLL-------QHNKSNIVKEAAWTVSNI 351
            .:.|..|..||.:|||..|.|.|||:::.:   |:..:::       :|:     .||||.:||:
 Worm   261 TDKSCNVSCLRLIGNIAVGNDVQTDLLVDN---PKFRVVMNIAMSSPEHH-----SEAAWIISNV 317

  Fly   352 TAGNQKQIQAVIQ--AGIFQQLRTVLEKGDFKAQKEAAWAVTNTTTSGTPEQIVDLIEKYKILKP 414
            .||..:.:..::.  ...::.:...:..||.:.:||..|.:.|...:....|.. |:....|::.
 Worm   318 VAGAPRHVDYIMDDPDAFYEWVMAGIHTGDKRLRKECLWIIGNLLATADEHQTY-LLVSLGIVQH 381

  Fly   415 FIDLLDTKDPRTIKVVQTGLS----------NLFALAEKLGGTE----NLCLMVEEMGGLDKLET 465
            |..|||..|.|..:...|..:          .||...:.||..|    |..:...|:..|.....
 Worm   382 FPALLDFDDVRLNEKAATTATELLREHPWQYTLFQRLDILGCIERAGANFSIQKAELKSLMNDLA 446

  Fly   466 LQQHENEEVYKKAYAIIDTYFSNGDD 491
            ..:.::|::.|....|  .|....||
 Worm   447 PPERKDEDIAKGCSVI--CYSKLSDD 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pen	NP_477041.1	SRP1	2..517	CDD:227396	115/545 (21%)
		HEAT repeat	70..102	CDD:293787	4/31 (13%)
		armadillo repeat	108..140	CDD:293788	4/31 (13%)
		armadillo repeat	148..184	CDD:293788	11/35 (31%)
		armadillo repeat	190..225	CDD:293788	4/34 (12%)
		armadillo repeat	359..396	CDD:293788	6/38 (16%)
		armadillo repeat	402..437	CDD:293788	9/44 (20%)
F53B2.5	NP_502400.2	ARM	69..186	CDD:237987	28/148 (19%)
		armadillo repeat	69..97	CDD:293788	8/47 (17%)
		armadillo repeat	105..141	CDD:293788	11/35 (31%)
		armadillo repeat	147..184	CDD:293788	5/48 (10%)
		ARM	294..400	CDD:237987	24/111 (22%)
		armadillo repeat	369..400	CDD:293788	9/31 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5064
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54553
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820