Protein Alignment Pen and ima-3

DIOPT Version :10

• Sequence 1: NP_477041.1
• Gene: Pen / 34338
• FlyBaseID: FBgn0287720
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_501227.1
• Gene: ima-3 / 177533
• WormBaseID: WBGene00002074
• Length: 514
• Species: Caenorhabditis elegans
• Alignment Length: 524
• Identity: 237/524 - (45%)
• Similarity: 326/524 - (62%)
• Gaps: 20/524 - (3%)

  Fly     6 SNSRQGSYKANSINTQDSRMRRHEVTIELRKSKKEDQMFKRRNIN------DEDLTSPLKELNGQ 64
            |::||..|| |:...|..:.:|:|..:.:||.|:|:.:.||||||      .|..|:|      .
 Worm     2 SSNRQAYYK-NNAKEQIGKEKRNEEVVSIRKDKREEAISKRRNINTQIEDDSETSTTP------P 59

  Fly    65 SPVQLSVDEI-VAAMNSEDQERQFLGMQSARKMLSRERNPPIDLMIGHGIVPICIRFLQNTNNSM 128
            .|...::..: |||..|.|...|...:|.||||||.:||||||.:||.||:|:.::.|.:|:.:
 Worm    60 GPFDANLLRLTVAAAQSSDPAEQLTAVQQARKMLSTDRNPPIDDLIGSGILPVLVQCLSSTDPN- 123

  Fly   129 LQFEAAWALTNIASGTSDQTRCVIEHNAVPHFVALLQSKSMNLAEQAVWALGNIAGDGAAARDIV 193
            |||||||||||||||||:||:.|:...|||.|:.||...::|:.||:|||||||.|||...||..
 Worm   124 LQFEAAWALTNIASGTSEQTQAVVNAGAVPLFLQLLSCGNLNVCEQSVWALGNIIGDGPHFRDYC 188

  Fly   194 IHHNVIDGILPLINNETPLSFLRNIVWLMSNLCRNKNPSPPFDQVKRLLPVLSQLLLSQDIQVLA 258
            :...::..:|..||.|.|:.||||:.|::.||||.|:|:|....|:.:||.||.|:..||..:|.
 Worm   189 LELGILQPLLQFINPEIPIGFLRNVTWVIVNLCRCKDPAPSPAVVRTILPALSLLIHHQDTNILI 253

  Fly   259 DACWALSYVTDDDNTKIQAVVDSDAVPRLVKLLQMDEPSIIVPALRSVGNIVTGTDQQTDVVIAS 323
            |..|||||:||..|..||.|:::..|..||.||...:..:...|||:|||||||||:||.:|:.|
 Worm   254 DTVWALSYLTDGGNEHIQMVIEAQVVTHLVPLLGHVDVKVQTAALRAVGNIVTGTDEQTQLVLDS 318

  Fly   324 GGLPRLGLLLQHNKSNIVKEAAWTVSNITAGNQKQIQAVIQAGIFQQLRTVLEKGDFKAQKEAAW 388
            |.|..:..||.|.|..|.|||.|.|||||||||:|:|.|..|||...:..:|::|||..||||||
 Worm   319 GVLRFMPGLLAHYKEKINKEAVWFVSNITAGNQQQVQDVFDAGIMPMIIHLLDRGDFPTQKEAAW 383

  Fly   389 AVTNTTTSGTPEQIVDLIEKYKILKPFIDLLDTKDPRTIKVVQTGLSNLFALAEKLGGTENLCLM 453
            |::|.|.||.|.|:..:: |..:|:||..:|...|.:.|:||..|::|:..:|.:  ..|.:...
 Worm   384 AISNVTISGRPNQVEQMV-KLGVLRPFCAMLSCTDSQIIQVVLDGINNILKMAGE--AAEQVTSE 445

  Fly   454 VEEMGGLDKLETLQQHENEEVYKKAYAIIDTYFSNGDDEAEQELAPQEVNGALEFNATQPKAPEG 518
            :||.|||||:|.||.||||::||.|:.|||.:||:.|:....|.|.....|.  .....|.||.|
 Worm   446 IEECGGLDKIENLQNHENEDIYKLAFEIIDNFFSSDDETGNVEGAQSSAFGG--DVPPVPDAPNG 508

  Fly   519 GYTF 522
            |:.|
 Worm   509 GWNF 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pen	NP_477041.1	SRP1	2..517	CDD:227396	233/517 (45%)
		HEAT repeat	70..102	CDD:293787	13/32 (41%)
		armadillo repeat	108..140	CDD:293788	17/31 (55%)
		armadillo repeat	148..184	CDD:293788	18/35 (51%)
		armadillo repeat	190..225	CDD:293788	12/34 (35%)
		armadillo repeat	359..396	CDD:293788	18/36 (50%)
		armadillo repeat	402..437	CDD:293788	10/34 (29%)
ima-3	NP_501227.1	SRP1	19..513	CDD:227396	230/506 (45%)
		HEAT repeat	65..92	CDD:293787	9/26 (35%)
		armadillo repeat	103..135	CDD:293788	17/32 (53%)
		armadillo repeat	143..179	CDD:293788	18/35 (51%)
		armadillo repeat	185..220	CDD:293788	12/34 (35%)
		armadillo repeat	237..262	CDD:293788	13/24 (54%)
		armadillo repeat	272..304	CDD:293788	11/31 (35%)
		armadillo repeat	315..346	CDD:293788	15/30 (50%)
		armadillo repeat	354..391	CDD:293788	18/36 (50%)
		armadillo repeat	397..431	CDD:293788	10/34 (29%)
		armadillo repeat	443..476	CDD:293788	19/32 (59%)