Protein Alignment Pen and Kpna4

DIOPT Version :10

• Sequence 1: NP_477041.1
• Gene: Pen / 34338
• FlyBaseID: FBgn0287720
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_032493.1
• Gene: Kpna4 / 16649
• MGIID: 1100848
• Length: 521
• Species: Mus musculus
• Alignment Length: 518
• Identity: 243/518 - (46%)
• Similarity: 339/518 - (65%)
• Gaps: 7/518 - (1%)

  Fly     7 NSRQGSYKANSINTQDSRMRRHEVTIELRKSKKEDQMFKRRNINDEDLTSPLKELNGQSPVQ-LS 70
            |.|..::|....:.:..|.:|:||.:||||:|:::.:.||||:..||:... .:::|...|| .|
Mouse     9 NQRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNVPQEDICED-SDIDGDYRVQNTS 72

  Fly    71 VDEIVAAMNSEDQERQFLGMQSARKMLSRERNPPIDLMIGHGIVPICIRFLQNTNNSMLQFEAAW 135
            ::.||...:|::|..|...:|:|||:||.:||||||.:|..||:||.:..|:..:|..|||||||
Mouse    73 LEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAW 137

  Fly   136 ALTNIASGTSDQTRCVIEHNAVPHFVALLQSKSMNLAEQAVWALGNIAGDGAAARDIVIHHNVID 200
            ||||||||||:||:.|::.||||.|:.||.|...|:.||||||||||.|||...||.||...|:.
Mouse   138 ALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVK 202

  Fly   201 GILPLINNETPLSFLRNIVWLMSNLCRNKNPSPPFDQVKRLLPVLSQLLLSQDIQVLADACWALS 265
            .:|..|:...|::||||:.|:|.||||:|:|.||.:.::.:||.|..|:...|:.:|.|..||||
Mouse   203 PLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALS 267

  Fly   266 YVTDDDNTKIQAVVDSDAVPRLVKLLQMDEPSIIVPALRSVGNIVTGTDQQTDVVIASGGLPRLG 330
            |:||..|.:||.|:||..||.||.||...|..:...|||:|||||||||:||.||:....|....
Mouse   268 YLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFP 332

  Fly   331 LLLQHNKSNIVKEAAWTVSNITAGNQKQIQAVIQAGIFQQLRTVLEKGDFKAQKEAAWAVTNTTT 395
            .||.|.|..|.|||.|.:||||||||:|:||||.|.:...:..:|:||||..|||||||::|.|.
Mouse   333 ALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTI 397

  Fly   396 SGTPEQIVDLIEKYKILKPFIDLLDTKDPRTIKVVQTGLSNLFALAEKLGGTENLCLMVEEMGGL 460
            ||..:|:..||:: .::.||.:||..||.:.::||..||||:..:||  ...|.:..::||.|||
Mouse   398 SGRKDQVAYLIQQ-NVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAE--DQAETIANLIEECGGL 459

  Fly   461 DKLETLQQHENEEVYKKAYAIIDTYFSNGDDEAEQELAPQEV-NGALEFNATQPKAPEGGYTF 522
            :|:|.||.||||::||.||.|||.:||:.|.:.:..|.|:.| .|...||:: ...|..|:.|
Mouse   460 EKIEQLQNHENEDIYKLAYEIIDQFFSSDDIDEDPSLVPESVQGGTFGFNSS-TNVPTEGFQF 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pen	NP_477041.1	SRP1	2..517	CDD:227396	240/511 (47%)
		HEAT repeat	70..102	CDD:293787	12/31 (39%)
		armadillo repeat	108..140	CDD:293788	17/31 (55%)
		armadillo repeat	148..184	CDD:293788	21/35 (60%)
		armadillo repeat	190..225	CDD:293788	14/34 (41%)
		armadillo repeat	359..396	CDD:293788	19/36 (53%)
		armadillo repeat	402..437	CDD:293788	13/34 (38%)
Kpna4	NP_032493.1	SRP1	11..513	CDD:227396	239/506 (47%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O00629	43..52		4/8 (50%)
		ARM 1, truncated	66..106		16/39 (41%)
		armadillo repeat	73..98	CDD:293788	8/24 (33%)
		ARM 2	107..149		26/41 (63%)
		armadillo repeat	109..142	CDD:293788	17/32 (53%)
		NLS binding site (major). /evidence=ECO:0000250|UniProtKB:O00629	137..229		52/91 (57%)
		armadillo repeat	150..186	CDD:293788	21/35 (60%)
		armadillo repeat	192..227	CDD:293788	14/34 (41%)
		ARM 4	195..233		17/37 (46%)
		ARM 5	234..278		17/43 (40%)
		armadillo repeat	244..269	CDD:293788	11/24 (46%)
		ARM 6	279..318		22/38 (58%)
		armadillo repeat	279..311	CDD:293788	15/31 (48%)
		NLS binding site (minor). /evidence=ECO:0000250|UniProtKB:O00629	306..394		50/87 (57%)
		armadillo repeat	319..355	CDD:293788	16/35 (46%)
		ARM 8	361..400		20/38 (53%)
		armadillo repeat	361..395	CDD:293788	17/33 (52%)
		ARM 9	401..443		15/42 (36%)
		armadillo repeat	404..438	CDD:293788	13/34 (38%)
		ARM 10, atypical	447..485		21/37 (57%)