DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pen and Kpna2

DIOPT Version :9

Sequence 1:	NP_477041.1	Gene:	Pen / 34338	FlyBaseID:	FBgn0267727	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_034785.1	Gene:	Kpna2 / 16647	MGIID:	103561	Length:	529	Species:	Mus musculus

Alignment Length:	522	Identity:	264/522 - (50%)
Similarity:	357/522 - (68%)	Gaps:	11/522 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SRQGSYKANSINTQDSRMRRHEVTIELRKSKKEDQMFKRRNIND--EDLTSPLKE-LNGQSPVQL 69
            :|...:|....::.:.|.||.||.:||||:||::||.||||::.  :|.||||:| .|.|..|..
Mouse    12 ARLNRFKNKGKDSTEMRRRRIEVNVELRKAKKDEQMLKRRNVSSFPDDATSPLQENRNNQGTVNW 76

  Fly    70 SVDEIVAAMNSEDQERQFLGMQSARKMLSRERNPPIDLMIGHGIVPICIRFLQNTNNSMLQFEAA 134
            ||::||..:||.:.|.|....|:|||:||||:.||||.:|..|::|..:.||..|:.|.:|||:|
Mouse    77 SVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESA 141

  Fly   135 WALTNIASGTSDQTRCVIEHNAVPHFVALLQSKSMNLAEQAVWALGNIAGDGAAARDIVIHHNVI 199
            |||||||||||:||:.|::..|:|.|::||.|...:::||||||||||||||:|.||:||.|..|
Mouse   142 WALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAI 206

  Fly   200 DGILPLIN----NETPLSFLRNIVWLMSNLCRNKNPSPPFDQVKRLLPVLSQLLLSQDIQVLADA 260
            |.:|.|:.    :.....:|||:.|.:|||||||||:||.|.|:::||.|.:||...|.:||||:
Mouse   207 DPLLALLAVPDLSTLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADS 271

  Fly   261 CWALSYVTDDDNTKIQAVVDSDAVPRLVKLLQMDEPSIIVPALRSVGNIVTGTDQQTDVVIASGG 325
            |||:||:||..|.:|:.||....||:|||||...|..|:.||||::||||||||:||..||.:|.
Mouse   272 CWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGTDEQTQKVIDAGA 336

  Fly   326 LPRLGLLLQHNKSNIVKEAAWTVSNITAGNQKQIQAVIQAGIFQQLRTVLEKGDFKAQKEAAWAV 390
            |.....||.:.|:||.|||.||:||||||.|.|||.|:..|:...|..||.|.|||.|||||||:
Mouse   337 LAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAI 401

  Fly   391 TNTTTSGTPEQIVDLIEKYKILKPFIDLLDTKDPRTIKVVQTGLSNLFALAEKLGGTENLCLMVE 455
            ||.|:.||.||||.|:. ..|::|.::||..||.:.|:|:...:||:|..|||||.||.|.:|:|
Mouse   402 TNYTSGGTVEQIVYLVH-CGIIEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIE 465

  Fly   456 EMGGLDKLETLQQHENEEVYKKAYAIIDTYFSNGDDEAEQELAPQEVNGALEFNATQPKAPEGGY 520
            |.|||||:|.||:||||.|||.:..:|:.||| .::|.:|.:.|:..:....|. .|..|| |.:
Mouse   466 ECGGLDKIEALQRHENESVYKASLNLIEKYFS-VEEEEDQNVVPETTSEGFAFQ-VQDGAP-GTF 527

  Fly   521 TF 522
            .|
Mouse   528 NF 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pen	NP_477041.1	SRP1	2..517	CDD:227396	261/515 (51%)
		HEAT repeat	70..102	CDD:293787	16/31 (52%)
		armadillo repeat	108..140	CDD:293788	15/31 (48%)
		armadillo repeat	148..184	CDD:293788	18/35 (51%)
		armadillo repeat	190..225	CDD:293788	14/38 (37%)
		armadillo repeat	359..396	CDD:293788	21/36 (58%)
		armadillo repeat	402..437	CDD:293788	12/34 (35%)
Kpna2	NP_034785.1	SRP1	9..528	CDD:227396	263/519 (51%)
		IBB	10..98	CDD:280005	36/85 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..70		12/24 (50%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:10201409, ECO:0000269\|PubMed:10764582	45..54		6/8 (75%)
		ARM 1, truncated	71..111		18/39 (46%)
		ARM 2	112..151		21/38 (55%)
		ARM	113..238	CDD:237987	63/124 (51%)
		armadillo repeat	115..147	CDD:293788	15/31 (48%)
		NLS binding site (major)	142..238		51/95 (54%)
		armadillo repeat	155..191	CDD:293788	18/35 (51%)
		armadillo repeat	197..236	CDD:293788	14/38 (37%)
		ARM 4	200..244		20/43 (47%)
		ARM 5	246..282		19/35 (54%)
		ARM	252..364	CDD:237987	61/111 (55%)
		armadillo repeat	253..278	CDD:293788	14/24 (58%)
		ARM 6	283..322		20/38 (53%)
		armadillo repeat	288..320	CDD:293788	16/31 (52%)
		NLS binding site (minor)	315..403		51/87 (59%)
		armadillo repeat	328..364	CDD:293788	18/35 (51%)
		ARM	329..449	CDD:237987	60/120 (50%)
		ARM 8	367..409		23/41 (56%)
		armadillo repeat	370..404	CDD:293788	19/33 (58%)
		ARM 9	410..456		20/46 (43%)
		armadillo repeat	413..447	CDD:293788	12/34 (35%)
		ARM 10, atypical	457..496		22/38 (58%)
		HEAT repeat	457..494	CDD:293787	22/36 (61%)
		Arm_3	458..508	CDD:292804	26/50 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I10173
eggNOG	1	0.900	-	-		E1_COG5064
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1708
Inparanoid	1	1.050	492	1.000	Inparanoid score	I1391
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54553
OrthoDB	1	1.010	-	-		D1111872at2759
OrthoFinder	1	1.000	-	-		FOG0000157
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100442
Panther	1	1.100	-	-	LDO	PTHR23316
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4606
SonicParanoid	1	1.000	-	-		X4000
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.870