Protein Alignment Pen and Kap-alpha3

DIOPT Version :10

• Sequence 1: NP_477041.1
• Gene: Pen / 34338
• FlyBaseID: FBgn0287720
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: XP_321878.4
• Gene: Kap-alpha3 / 1281905
• VectorBaseID: AGAMI1_013593
• Length: 518
• Species: Anopheles gambiae
• Alignment Length: 536
• Identity: 247/536 - (46%)
• Similarity: 331/536 - (61%)
• Gaps: 32/536 - (5%)

  Fly     1 MSKADSNS--RQGSYKANSINTQDSRMRRHEVTIELRKSKKEDQMFKRRNI-------NDEDLT- 55
            |:..||.|  |...:|....:..:.|.||.|||:||||:|:|:.:.||||:       ::||.|
Mosquito     1 MASIDSQSKNRMQGFKNKGKDQDEMRRRRTEVTVELRKNKREETILKRRNVPQTTESTDEEDYTL 65

  Fly    56 -SPLKELNGQSPVQLSVDEIVAAMNSEDQERQFLGMQSARKMLSRERNPPIDLMIGHGIVPICIR 119
             |.||:|            :..|.||.|:|.|...:|:||::||.:|||||:.:|..||:||.:.
Mosquito    66 QSNLKKL------------VEKAGNSSDKEGQLAAVQAARRLLSSDRNPPINNLIDSGILPILVN 118

  Fly   120 FLQNTNNSMLQFEAAWALTNIASGTSDQTRCVIEHNAVPHFVALLQSKSMNLAEQAVWALGNIAG 184
            .|:..:|.:||||||||||||||||:.||..|:...|||.|:.||.|.:.|:.||||||||||.|
Mosquito   119 CLEQDDNQVLQFEAAWALTNIASGTAAQTNQVVRAGAVPLFLRLLNSPAPNVCEQAVWALGNIIG 183

  Fly   185 DGAAARDIVIHHNVIDGILPLINNETPLSFLRNIVWLMSNLCRNKNPSPPFDQVKRLLPVLSQLL 249
            ||.:.||.||...|:..:|..|..|.|:.||||:.|::.||||||:|.||...:..:||.|:.|:
Mosquito   184 DGPSLRDYVIKLGVVQPLLSFIQPEIPIPFLRNVTWVIVNLCRNKDPPPPAATILEILPALNMLI 248

  Fly   250 LSQDIQVLADACWALSYVTDDDNTKIQAVVDSDAVPRLVKLLQMDEPSIIVPALRSVGNIVTGTD 314
            ...||.:|.|..|||||:||..|.:||.|:||..||:|:.||...|..:...|||:|||||||:|
Mosquito   249 HHTDINILVDTVWALSYLTDGGNEQIQLVIDSGVVPKLIPLLSHVEVKVQTAALRAVGNIVTGSD 313

  Fly   315 QQTDVVIASGGLPRLGLLLQHNKSNIVKEAAWTVSNITAGNQKQIQAVIQAGIFQQLRTVLEKGD 379
            .||.||:....|.....||.|:|..|.|||.|.:||||||||.|:||||.||:..::...|:.||
Mosquito   314 DQTQVVLNCDALSHFPKLLTHSKDKIRKEAVWFLSNITAGNQSQVQAVIDAGLLPKVIENLKHGD 378

  Fly   380 FKAQKEAAWAVTNTTTSGTPEQIVDLIEKYKILKPFIDLLDTKDPRTIKVVQTGLSNLFALAEKL 444
            |..|||||||::|.|.||..||:..||....: .||.|||..:|.:.|.||..|::|:.    ||
Mosquito   379 FHTQKEAAWAISNLTISGNREQVAQLINDGAV-PPFCDLLMCQDCQVINVVLDGINNML----KL 438

  Fly   445 GG--TENLCLMVEEMGGLDKLETLQQHENEEVYKKAYAIIDTYFSNGDDEAE-QELAPQEVNGAL 506
            .|  .|::..::||..|:.|:|.||.|||.|:||.||.||:.:||:..|||. ::|.|.....|.
Mosquito   439 AGPHAEHVANLIEECDGVSKIEVLQNHENVEIYKLAYDIIEQFFSDDVDEAVLEDLRPAADENAF 503

  Fly   507 EFNATQPKAPEGGYTF 522
            :|| ..|..|..|:.|
Mosquito   504 QFN-QNPNIPRDGFNF 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pen	NP_477041.1	SRP1	2..517	CDD:227396	243/528 (46%)
		HEAT repeat	70..102	CDD:293787	11/31 (35%)
		armadillo repeat	108..140	CDD:293788	17/31 (55%)
		armadillo repeat	148..184	CDD:293788	20/35 (57%)
		armadillo repeat	190..225	CDD:293788	14/34 (41%)
		armadillo repeat	359..396	CDD:293788	19/36 (53%)
		armadillo repeat	402..437	CDD:293788	12/34 (35%)
Kap-alpha3	XP_321878.4	SRP1	8..510	CDD:227396	240/519 (46%)
		armadillo repeat	107..139	CDD:293788	17/31 (55%)
		armadillo repeat	147..183	CDD:293788	20/35 (57%)
		armadillo repeat	189..224	CDD:293788	14/34 (41%)
		armadillo repeat	241..266	CDD:293788	12/24 (50%)
		armadillo repeat	274..310	CDD:293788	18/35 (51%)
		armadillo repeat	316..350	CDD:293788	14/33 (42%)
		armadillo repeat	358..392	CDD:293788	17/33 (52%)
		armadillo repeat	401..435	CDD:293788	12/34 (35%)