DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pen and kpna4

DIOPT Version :9

Sequence 1:	NP_477041.1	Gene:	Pen / 34338	FlyBaseID:	FBgn0267727	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	XP_002933281.2	Gene:	kpna4 / 100380091	XenbaseID:	XB-GENE-1011058	Length:	520	Species:	Xenopus tropicalis

Alignment Length:	518	Identity:	242/518 - (46%)
Similarity:	339/518 - (65%)	Gaps:	8/518 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NSRQGSYKANSINTQDSRMRRHEVTIELRKSKKEDQMFKRRNINDEDLTSPLKELNGQSPVQ-LS 70
            |.|..::|....:.:..|.:|:||.:||||:|:::.:.||||:..||:... .:::....|| .|
Frog     9 NQRLKNFKNKGRDLESMRRQRNEVVVELRKNKRDEHLLKRRNVPHEDICED-SDVDADFRVQNTS 72

  Fly    71 VDEIVAAMNSEDQERQFLGMQSARKMLSRERNPPIDLMIGHGIVPICIRFLQNTNNSMLQFEAAW 135
            ::.||...:|:.|..|...:|:|||:||.:||||||.:|..||:||.:..|:..:|..|||||||
Frog    73 LEAIVQNASSDHQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAW 137

  Fly   136 ALTNIASGTSDQTRCVIEHNAVPHFVALLQSKSMNLAEQAVWALGNIAGDGAAARDIVIHHNVID 200
            ||||||||||:||:.|::.||||.|:.||.|...|:.||||||||||.|||...||.||...|:.
Frog   138 ALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVK 202

  Fly   201 GILPLINNETPLSFLRNIVWLMSNLCRNKNPSPPFDQVKRLLPVLSQLLLSQDIQVLADACWALS 265
            .:|..||...|::||||:.|:|.||||:|:|.||.:.::.:||.|..|:...|:.:|.|..||||
Frog   203 PLLSFINPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALS 267

  Fly   266 YVTDDDNTKIQAVVDSDAVPRLVKLLQMDEPSIIVPALRSVGNIVTGTDQQTDVVIASGGLPRLG 330
            |:||..|.:||.|:||..|..||.||...|..:...|||:|||||||||:||.||:....|....
Frog   268 YLTDAGNEQIQMVIDSGIVTNLVPLLSNPEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALLHFP 332

  Fly   331 LLLQHNKSNIVKEAAWTVSNITAGNQKQIQAVIQAGIFQQLRTVLEKGDFKAQKEAAWAVTNTTT 395
            .||.|.|..|.|||.|.:||||||||:|:||||.|.:...:..:|:||||..|||||||::|.|.
Frog   333 ALLTHAKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTI 397

  Fly   396 SGTPEQIVDLIEKYKILKPFIDLLDTKDPRTIKVVQTGLSNLFALAEKLGGTENLCLMVEEMGGL 460
            ||..:|:..||:: .::.||.:||..|||:.|:||..||||:..:|::  .:|.:..::||.|||
Frog   398 SGRKDQVAYLIQQ-NVIPPFCNLLTVKDPQVIQVVLDGLSNILKMADE--DSETIANLIEECGGL 459

  Fly   461 DKLETLQQHENEEVYKKAYAIIDTYFSNGDDEAEQELAPQEV-NGALEFNATQPKAPEGGYTF 522
            :|:|.||.||||::||.|:.|||.:||:..|| :..|.|:.: .|...||:: ...|..|:.|
Frog   460 EKIEQLQSHENEDIYKLAFEIIDQFFSSDIDE-DSNLVPETIQGGTFSFNSS-ANVPAEGFQF 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pen	NP_477041.1	SRP1	2..517	CDD:227396	239/511 (47%)
		HEAT repeat	70..102	CDD:293787	12/31 (39%)
		armadillo repeat	108..140	CDD:293788	17/31 (55%)
		armadillo repeat	148..184	CDD:293788	21/35 (60%)
		armadillo repeat	190..225	CDD:293788	15/34 (44%)
		armadillo repeat	359..396	CDD:293788	19/36 (53%)
		armadillo repeat	402..437	CDD:293788	15/34 (44%)
kpna4	XP_002933281.2	SRP1	11..519	CDD:227396	240/513 (47%)
		armadillo repeat	73..98	CDD:293788	8/24 (33%)
		armadillo repeat	109..142	CDD:293788	17/32 (53%)
		armadillo repeat	150..186	CDD:293788	21/35 (60%)
		armadillo repeat	192..227	CDD:293788	15/34 (44%)
		armadillo repeat	244..269	CDD:293788	11/24 (46%)
		armadillo repeat	279..311	CDD:293788	14/31 (45%)
		armadillo repeat	319..355	CDD:293788	16/35 (46%)
		armadillo repeat	361..395	CDD:293788	17/33 (52%)
		armadillo repeat	404..438	CDD:293788	15/34 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1111872at2759
OrthoFinder	1	1.000	-	-		FOG0000157
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010