DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13127 and CG42820

DIOPT Version :9

Sequence 1:	NP_609338.1	Gene:	CG13127 / 34335	FlyBaseID:	FBgn0032176	Length:	734	Species:	Drosophila melanogaster
Sequence 2:	NP_995659.1	Gene:	CG42820 / 34161	FlyBaseID:	FBgn0262002	Length:	689	Species:	Drosophila melanogaster

Alignment Length:	783	Identity:	194/783 - (24%)
Similarity:	333/783 - (42%)	Gaps:	187/783 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KSLGFRHNIDSVRWYRGMSVVQMKACDELLHALRDDMEQGSTYRVRHCITQLGIYPPVGAAQIKD 68
            |:.|....:....||||:|:.||:|.|||..||:.|:..     :|.|:.:||:.|.:...::..
  Fly     3 KNTGVDLGLPVASWYRGLSLDQMQAADELGTALQFDIRS-----IRDCLLRLGVQPLIRNRELHR 62

  Fly    69 IIAMSQGSDLAFLWFLWEFAYKSPPKCGKDNCNSDSEHFTVNEQLLLSGIAHLDMPSTLRALDAL 133
            |...|:|..||||:||::..|.:...|||         ::||.|||||.||:||:|:|.||||.:
  Fly    63 IWRFSRGQKLAFLYFLFQEHYDTGTSCGK---------YSVNGQLLLSAIAYLDLPATFRALDKV 118

  Fly   134 LP-PATQSKKLNSQIKTEQKSS---------IPRRRK-PKNYD--LPYFAPLV------------ 173
            || |.....:...|:|..|.::         ||..:. |:|.|  :|...|..
  Fly   119 LPLPGVLCGQTKIQMKNRQINNNRSARPSIIIPNSKTYPQNIDEEMPLDLPATFRALDKVLSSHT 183

  Fly   174 ---RP----REYIPKCKFRPPETKLLFPEYSHYIDRMK-QIPNE-------GSRWFAQYKLCPAK 223
               :|    :.|..:.:.||..|.....::......:| |||||       ..||:|.::..|.:
  Fly   184 TKKKPSSSRKSYYFQKQPRPKTTPRRSNQFLSDSPLLKIQIPNEVGDPKEDEDRWYADFQFHPIQ 248

  Fly   224 RVVNKLLRDQLNGISLKWDDNLEDNA----PVCETHRFLKKVEN---LQKQEKILKQPCVTMLDV 281
            |.|..:::.:|..:....|:...|.|    .:|..|...:..|.   ||:|    ::..:.|:|:
  Fly   249 RTVKAVIKHELCHLFDHIDEVTTDPAQKARDLCGFHEETRTQERQAFLQEQ----RRRYLDMIDL 309

  Fly   282 VGDELKARRKHILNDIENNV-----KWASKRMNRQLGITSGPGKLPKGSCTARKKKEPTILIGLG 341
            .|...:..|:.||:.|..:|     |:..|      |.:.|.....|..|.|
  Fly   310 EGTAKRLTRERILHHINRDVDEYLLKFGDK------GWSPGVPAFRKAGCVA------------- 355

  Fly   342 NEENLRLHSYAH-SLNNSIRVMLMKGNESH---RCGAGDCKILDVDCEMKGSAEITMKPQNVKSF 402
                  .:...| ||:...:|:|::|....   |.||    ::.:.....|..::..:.:..:.
  Fly   356 ------CNELVHVSLDTPPQVLLLEGEWGRLYDRSGA----LMRLCAGEDGEPDVLAEEEQEEE- 409

  Fly   403 IEEKPRLPTSSFKKLADLIPVCSRTLRSLKRSSPKAPAEESFTNRSIGG---FQLDYHKIFDVPS 464
             |:...:|                               |.||  |.|.   |..:|..:|...|
  Fly   410 -EDSIAIP-------------------------------EYFT--SPGDHKPFAFNYPHVFKRNS 440

  Fly   465 PPVEPLPWEEEVLDLEDKQPVIERLCIDALGNDDNKSKKELLRNKSNPV----VSRSAAKCAVNM 525
                     ::.||..|   |:::..::|||...|:.::.:|  .|.|:    ::.:.::|...:
  Fly   441 ---------KQSLDTND---VVKKSLMEALGGQKNEHRQGVL--ASGPIRRSHINEAVSRCVRKI 491

  Fly   526 FRSKLAENAENQDDK----HIKQNGDILIDPDDDEQIESLLKEALRVLRGNRQYVLATLSNAHKM 586
            |...|.........|    .:..|.: .||||||:.::.:|.:...:||.:.:.|||:|.|.|::
  Fly   492 FEKSLLAVPTTPTPKDSIERLVYNRE-RIDPDDDKFMDQMLSDGFEILRRDSKLVLASLHNGHQI 555

  Fly   587 PVLLDWVADRYGKSYCRAGMKSIVKTSFRIYEKVYEKERRNKRNMLELKRSVTGLGSSIS----- 646
            |.:.:|:..||||.|   |.:|         ...:|..|.|...:.|:::.:..|.::|.
  Fly   556 PEVREWICRRYGKRY---GPQS---------HADFESYRHNMAKLSEMEKKLIPLLTNIDPLIVK 608

  Fly   647 -----YASHKKFMSQVVQRKAEYNNKLNELALEQSRLTWLALRGYSHLGGS-IKDTFFAYMPARP 705
                 ||.||:.|.:..:.|..:.:::.::.|:||||.|.|......:..| |:.|||.|:|:..
  Fly   609 QNPIPYALHKEIMEKSNKFKKSFRDEVLQIVLKQSRLCWQAQHSLRFVNSSRIRRTFFTYLPSSV 673

  Fly   706 QDI 708
            :.|
  Fly   674 RSI 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13127	NP_609338.1	DUF4770	52..226	CDD:292613	62/213 (29%)
CG13127	NP_609338.1	DUF4771	550..708	CDD:292614	50/168 (30%)
CG42820	NP_995659.1	DUF4770	46..252	CDD:292613	62/214 (29%)
CG42820	NP_995659.1	DUF4771	517..676	CDD:292614	50/171 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2C9W7
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0009976
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR41967
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.000