DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trp1 and Sec62

DIOPT Version :9

Sequence 1:	NP_723510.1	Gene:	Trp1 / 34333	FlyBaseID:	FBgn0011584	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_001344457.1	Gene:	Sec62 / 69276	MGIID:	1916526	Length:	410	Species:	Mus musculus

Alignment Length:	394	Identity:	149/394 - (37%)
Similarity:	225/394 - (57%)	Gaps:	46/394 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 QKVDKPSKDEKNVAKWLKKNVKTKKTKFLSHIVEYFTSSKAIDALLKSKFT---EGSNPLFTTRE 94
            |:|.:|||:||.|||:|:.|..||.|..:.|.|:||.:|||::.||.||:.   :|.:.||||||
Mouse    12 QEVGEPSKEEKAVAKYLRFNCPTKSTNMMGHRVDYFIASKAVECLLDSKWAKAKKGEDALFTTRE 76

  Fly    95 QVIEFLDVMLEHKFFHRAKKV-------PVTLEEIRGKSGG----DKKADKEKTQDKEKDKAKDE 148
            .|:::.:.:|:.:|||||.||       .|..|:.:|||..    |||:.||..::::..|.|::
Mouse    77 SVVDYCNRLLKKQFFHRALKVMKMKYDKDVKKEKDKGKSESGKEDDKKSKKESVKEEKTKKEKEK 141

  Fly   149 KKDTDPEGDNGQGDGGASGNEKEKEKKEKKKRKIRLDMHPEQIFVDGSEAYVWIYDPIPLHYWIF 213
            |||.:.|....:...|.       .||::.|:|.:|:.|.:|:|:||:|.:||||||:.:..::.
Mouse   142 KKDGEKEDSKKEETPGT-------PKKKETKKKFKLEPHDDQVFLDGNEVFVWIYDPVHIKTFVM 199

  Fly   214 GFILLLGAVGICLFPLWPPLLRKGVYYLSIAAAGFLVFILALTIVRLIVFIIVWALTGGKLHFWI 278
            |.||::..:...||||||..:|.||||||:.|..|:..||.|.|.|.|:|:|:|.:|||:.|||.
Mouse   200 GLILVIAVIAATLFPLWPAEMRVGVYYLSVGAGCFVASILLLAIARCILFLIIWLITGGRHHFWF 264

  Fly   279 FPNLTEDVSFFASFWPLYESNYNSDPNNSSAKTDKKSKSKDKKK---------EKESDAEDTAVD 334
            .||||.||.|..||.|||...|...  .:..|.|:||::|.::|         ||:.|.|.....
Mouse   265 LPNLTADVGFIDSFRPLYTHEYKGP--KADLKKDEKSETKKQQKSDSEEKSDSEKKEDEEGKGAP 327

  Fly   335 AD-------GDADGDVDAEVSTLEPEKIELIKEHDTDMEIRKRRKV-----GADDYEEDDVDEEE 387
            ||       |:...|.|::  ..|.::.:....:..|.|:..:.::     |..|.|:||.|.|.
Mouse   328 ADHGPEGSGGERHSDTDSD--RREDDRSQHSSGNGNDFEMITKEELEQQTDGDCDEEDDDKDGEL 390

  Fly   388 TKAQ 391
            .|:|
Mouse   391 RKSQ 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trp1	NP_723510.1	Sec62	105..303	CDD:281790	87/208 (42%)
Sec62	NP_001344457.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	106..167		20/67 (30%)
		Sec62	<170..304	CDD:309099	64/135 (47%)
		TFIIFa	<290..>369	CDD:331821	18/80 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833718
Domainoid	1	1.000	178	1.000	Domainoid score	I3566
eggNOG	1	0.900	-	-		E1_COG5232
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	257	1.000	Inparanoid score	I3130
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49369
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005183
OrthoInspector	1	1.000	-	-		oto91962
orthoMCL	1	0.900	-	-		OOG6_107760
Panther	1	1.100	-	-	LDO	PTHR12443
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1311
SonicParanoid	1	1.000	-	-		X4215
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.790