DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SoYb and Ddx17

DIOPT Version :9

Sequence 1:	NP_001245959.1	Gene:	SoYb / 34331	FlyBaseID:	FBgn0051755	Length:	1476	Species:	Drosophila melanogaster
Sequence 2:	NP_951062.1	Gene:	Ddx17 / 67040	MGIID:	1914290	Length:	652	Species:	Mus musculus

Alignment Length:	492	Identity:	93/492 - (18%)
Similarity:	181/492 - (36%)	Gaps:	97/492 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   416 NPSERSVQK--NRSQMPNSN----------VSTTKRCVEKMHVCRSENMGDRKPSVCLKHLVLAH 468
            ||.||..:|  :.|::|...          ...|...|:::.  |.:.:..|...||.|
Mouse    33 NPGERLRKKKWDLSELPKFEKNFYVEHPEVARLTPYEVDELR--RKKEITVRGGDVCPK------ 89

  Fly   469 SPEPVNPVTSYKELPLGNTILNAMDDLNFQTPLPTQIYAWPHLVNRGSLVLVNPSGTGRSWSYLP 533
                  ||.::........:::.:.|.:|..|.|.|...:|..::...:|.:..:|:|::.:||
Mouse    90 ------PVFAFHHANFPQYVMDVLMDQHFTEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYL- 147

  Fly   534 VICSSVLSSFENVTSNLDTRIAPGPLAILIVDSVENAKKLASHCEFLMKDF-NTQNLKVVNTHAH 597
                  |.:..::..........||:.:::..:    ::||...:.:..|: ....||....:..
Mouse   148 ------LPAIVHINHQPYLERGDGPICLVLAPT----RELAQQVQQVADDYGKCSRLKSTCIYGG 202

  Fly   598 SMMDVYMM-LLNSCGVLVTTLAHLNNILSNELPLVNPTRLEFIIFDDYDRKRLDNAELLKEVFQK 661
            :.....:. |.....:.:.|...|.:.|  |....|..|..:::.|:.|| .||.
Mouse   203 APKGPQIRDLERGVEICIATPGRLIDFL--ESGKTNLRRCTYLVLDEADR-MLDM---------- 254

  Fly   662 VNSIGGLSKQLVLVAQQWHSERFQKLLNRTTKP---LILFGDFLEAALYGGLKFNVTLRSSALKA 723
                 |...|:..:..|...:| |.|:...|.|   ..|..|||..  |..:.......|:....
Mouse   255 -----GFEPQIRKIVDQIRPDR-QTLMWSATWPKEVRQLAEDFLRD--YTQINVGNLELSANHNI 311

  Fly   724 RQLLDILAEQDGSKKRTLIYCKNQMELEELSAILIEAGLQCVDISKAQNQS--PNRLMLVDDSQV 786
            .|::|:..|.:...|...:..:...|.|..:.|.:|...:|.|:::...:.  |...:..|.||.
Mouse   312 LQIVDVCMESEKDHKLIQLMEEIMAEKENKTIIFVETKRRCDDLTRRMRRDGWPAMCIHGDKSQP 376

  Fly   787 RKQ-----------------------LPVRNIQLLIHFSLPESWLRFSRRFHTMADNIRN----L 824
            .:.                       |.|.:::.:|::..|.|...:..|....|.:...    .
Mouse   377 ERDWVLNEFRSGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYVHRIGRTARSTNKGTAYT 441

  Fly   825 FTKP--IGRGQDLITYILMDENNAKEWPRIMKFLQDH 859
            |..|  :.:.::||.  :::|.|....|::|: |.||
Mouse   442 FFTPGNLKQARELIK--VLEEANQAINPKLMQ-LVDH 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SoYb	NP_001245959.1	TUDOR	7..115	CDD:278965
		SrmB	475..877	CDD:223587	79/421 (19%)
		P-loop_NTPase	480..>646	CDD:304359	27/167 (16%)
		TUDOR	927..1043	CDD:278965
Ddx17	NP_951062.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38		3/4 (75%)
		DEXDc	32..502	CDD:331760	93/492 (19%)
		Q motif	92..120		4/27 (15%)
		DEAD box	246..249		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	585..652
		Interaction with YAP1. /evidence=ECO:0000250\|UniProtKB:Q92841	641..649
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910