DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SoYb and Ddx46

DIOPT Version :9

Sequence 1:	NP_001245959.1	Gene:	SoYb / 34331	FlyBaseID:	FBgn0051755	Length:	1476	Species:	Drosophila melanogaster
Sequence 2:	NP_001268984.1	Gene:	Ddx46 / 212880	MGIID:	1920895	Length:	1032	Species:	Mus musculus

Alignment Length:	736	Identity:	135/736 - (18%)
Similarity:	271/736 - (36%)	Gaps:	178/736 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   210 SFEKAEINDMAIDTRPRLRRILELVVLLSENAKESTPTPSA--IQQKKLDALLQSHETYLIPNSV 272
            |.||||..|.:.:.:.            .::.||......|  ..|.||:..::
Mouse   120 SKEKAEGGDSSKEKKK------------DKDDKEDEKEKDAGNFDQNKLEEEMR----------- 161

  Fly   273 KLLSKVQSISESSMQTALAN---RSKQISKELPHKANQSEDN---------RKKEVKYLESENLS 325
            |...:|:...|...:.|:.|   ..|:|.:....|....||:         .:||...:|.|.|.
Mouse   162 KRKERVEKWREEQRKKAMENIGELKKEIEEMKQGKKWSLEDDDDDEDDPAEAEKEGTEMEDEELD 226

  Fly   326 ECLSKVKLSSYQQKNTDSSTLSGPRNLASSSTNSNSNVRKSMTLFKSSGAHLTTSLSVPLTENCT 390
                  .|.:|.::..:.......|::...:.|.           |.||..:|..::|..|:...
Mouse   227 ------PLDAYMEEVKEEVKKFNMRSVKGGAGNE-----------KKSGPTVTKVVTVVTTKKAV 274

  Fly   391 NQSNNR----------TVVFSMDKME-QIFNDMLGKNPSERSV--------------QKN-RSQM 429
            ..::.:          .:.:|.::.| .:...:.|....:|.:              :|| ..::
Mouse   275 VDADKKKGELMENDQDAMEYSSEEEEVDLQTALTGYQTKQRKLLEPVDHGKIEYEPFRKNFYVEV 339

  Fly   430 PNSNVSTTKRCVEKMHVCRSENMG-DRKPSVCLKHLVLAHSPEPVNPVTSYKELPLGNTILNAMD 493
            |    ...|...|:::|.|.|..| ..|...|.|            |:.|:.:..:...|||::.
Mouse   340 P----ELAKMSQEEVNVFRLEMEGITVKGKGCPK------------PIKSWVQCGISMKILNSLK 388

  Fly   494 DLNFQTPLPTQIYAWPHLVNRGSLVLVNPSGTGRSWSYLPVICSSVLSSFENVTSNLDTRIAPGP 558
            ...::.|.|.|..|.|.:::...|:.:..:|:|::.::|       |..|.::..........||
Mouse   389 KHGYEKPTPIQTQAIPAIMSGRDLIGIAKTGSGKTIAFL-------LPMFRHIMDQRSLEEGEGP 446

  Fly   559 LAILIVDSVENAKKLASHCEFLMKDFNTQNLKVVNTHAHS-MMDVYMMLLNSCGVLVTTLAHLNN 622
            :|:::..:.|.|.::...|:...|   |..|:||..:..: :.:....|.....::|.|...:.:
Mouse   447 IAVIMTPTRELALQITKECKKFSK---TLGLRVVCVYGGTGISEQIAELKRGAEIIVCTPGRMID 508

  Fly   623 IL-SNELPLVNPTRLEFIIFDDYDRKRLDNAELLKEVFQKVNSIGGLSKQLVLVAQQWHSERFQK 686
            :| :|...:.|..|:.:::.|:.||           :|..     |...|::.:......:|...
Mouse   509 MLAANSGRVTNLRRVTYVVLDEADR-----------MFDM-----GFEPQVMRIVDNVRPDRQTV 557

  Fly   687 LLNRT-------------TKPL-ILFGDFLEAALYGGLKFNVTLRSSALKARQLLDILA--EQDG 735
            :.:.|             :||: :..|.  .:.:...::..|.:.....|..:||::|.  ::.|
Mouse   558 MFSATFPRAMEALARRILSKPIEVQVGG--RSVVCSDVEQQVIVIEEEKKFLKLLELLGHYQESG 620

  Fly   736 SKKRTLIYCKNQMELEELSAILIEAGLQCVDISKAQNQ-----------SPNRLMLVDDSQVRKQ 789
            |   .:|:...|...:.|...|:.|...|:.:....:|           :....:||..|...:.
Mouse   621 S---VIIFVDKQEHADGLLKDLMRASYPCMSLHGGIDQYDRDSIINDFKNGTCKLLVATSVAARG 682

  Fly   790 LPVRNIQLLIHFSLPESWLRFSRRFHTMADNIRNLFTKPIGR----GQDLITYILMDENNAKEWP 850
            |.|:::.|::::|.|..:..:..|               .||    |.....|..:.|:.|:...
Mouse   683 LDVKHLILVVNYSCPNHYEDYVHR---------------AGRTGRAGNKGYAYTFITEDQARYAG 732

  Fly   851 RIMKFLQDHGLTTQSMPDSEQ 871
            .|:|.|:..|  |...||.|:
Mouse   733 DIIKALELSG--TAVPPDLEK 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SoYb	NP_001245959.1	TUDOR	7..115	CDD:278965
		SrmB	475..877	CDD:223587	82/430 (19%)
		P-loop_NTPase	480..>646	CDD:304359	33/167 (20%)
		TUDOR	927..1043	CDD:278965
Ddx46	NP_001268984.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..227		27/135 (20%)
		SrmB	344..826	CDD:223587	91/468 (19%)
		Q motif	372..400		6/27 (22%)
		DEADc	378..581	CDD:238167	42/228 (18%)
		DEAD box	529..532		1/2 (50%)
		Helicase_C	618..714	CDD:278689	20/113 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0334
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810