DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SoYb and ddx-46

DIOPT Version :9

Sequence 1:	NP_001245959.1	Gene:	SoYb / 34331	FlyBaseID:	FBgn0051755	Length:	1476	Species:	Drosophila melanogaster
Sequence 2:	NP_001033411.1	Gene:	ddx-46 / 176943	WormBaseID:	WBGene00018776	Length:	970	Species:	Caenorhabditis elegans

Alignment Length:	909	Identity:	166/909 - (18%)
Similarity:	346/909 - (38%)	Gaps:	190/909 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   277 KVQSISESSMQTALANRSKQISK--------ELPHKANQSEDNRKKEVKYLESEN-------LSE 326
            :|..:.|:.:...:..|.:.:.|        ||..::.||::..:|:...||.|:       .:|
Worm    89 EVMKMKEAELLQGVERRRRNVEKWRAQKKKEELDLQSEQSDEKSEKKPWNLEDEDDEDEFDIKNE 153

  Fly   327 CLSK---VKLSSYQQKNTDSSTLSGP-----RNLASSSTNSNSNVRKSMTLFKSSGAHLTTSLSV 383
            .:|:   ||:....:| .|:.....|     :.:|:.:.....|..:     |:||.       |
Worm   154 GISEENPVKMEEKVEK-MDTDDEEDPLDAFMKEIATKNAKKTGNSTQ-----KASGI-------V 205

  Fly   384 PLTENCTNQSNNRTVVFSMDKMEQIFNDMLGKNPSERSVQKNR--SQMPNSNVSTTK-------- 438
            .:.:....:.....|:.:.|.|:.:.:|...:..:.....|.|  :|..:|.|...|
Worm   206 TIVQEEKPEPEKGQVLENEDNMDMVIDDFDIETAAASLCHKGRMLAQTDHSKVYYRKFKKNFYIE 270

  Fly   439 -RCVEKMHVCRSENMGDRKPSVCLKHLVLAHSPEPVNPVTSYKELPLGNTILNAMDDLNFQTPLP 502
             ..:.:|.....:...:...|:.:|.:   ..|:|:.   ::.:..:...::|.:....:..|..
Worm   271 TEEIRRMTKAEVKAYREELDSITVKGI---DCPKPIK---TWAQCGVNLKMMNVLKKFEYSKPTS 329

  Fly   503 TQIYAWPHLVNRGSLVLVNPSGTGRSWSYLPVICSSVLSSFENVTSNLDTRIAPGPLAILIVDSV 567
            .|..|.|.:::...::.:..:|:|::.::|       |..|.::....:.....||:|:::..:.
Worm   330 IQAQAIPSIMSGRDVIGIAKTGSGKTLAFL-------LPMFRHILDQPELEEGDGPIAVILAPTR 387

  Fly   568 ENAKKLASHCEFLMKDFNTQNLKVVNTH-----AHSMMDVYMMLLNSCGVLVTTLAHLNNIL-SN 626
            |.|.:.........|..   .|||..|:     :..:.|    |.....::|.|...:.::| :|
Worm   388 ELAMQTYKEANKFAKPL---GLKVACTYGGVGISEQIAD----LKRGAEIVVCTPGRMIDVLAAN 445

  Fly   627 ELPLVNPTRLEFIIFDDYDRKRLDNAELLKEVFQKVNSIGGLSKQLVLVAQQW--HSERF-QKLL 688
            ...:.|..|:.:::.|:.|  |:.:.....::.:.||:|.. .||.||.:..:  |.|.. :|:|
Worm   446 SGKVTNLRRVTYLVLDEAD--RMFDKGFEPQIMKVVNNIRP-DKQTVLFSATFPRHMEALARKVL 507

  Fly   689 NRTTKPL-ILFGDFLEAALYGGLKFNVTLRSSALKARQLLDILA--EQDGSKKRTLIYCKNQMEL 750
            :   ||: ||.|.  ::.:...:..|..:.:...|..:||::|.  .::||   ::::...|.:.
Worm   508 D---KPVEILVGG--KSVVCSDITQNAVICAEHQKFLKLLELLGMYYEEGS---SIVFVDKQEKA 564

  Fly   751 EELSAILIEAGLQCV------------DISKAQNQSPNRLMLVDDSQVRKQLPVRNIQLLIHFSL 803
            :::...|:..|...|            |.|.|..::....:||..|...:.|.|:|:.|::::..
Worm   565 DDIVDQLMRTGYNSVAPLHGGIDQHDRDSSIADFKTGVIKVLVATSVAARGLDVKNLILVVNYDC 629

  Fly   804 PESWLRFSRRFHTMADNIRNLFTKPIGRGQDLITYILMD--ENNAKEW-----------PRIMKF 855
            |..:..:..|...         |...||.....|::|.:  |..|.|.           |..:|.
Worm   630 PNHYEDYVHRVGR---------TGRAGRKGYAYTFVLPEHQEKMAGEICRAFETAGCKPPADLKA 685

  Fly   856 LQDHGLTTQSMPDSEQQLDNT-LPYCPYKLSNG----NCNRNQCNKRHHFLKT------DLPKIG 909
            :.:...:..:....|.:|... .....||...|    :.|:.:..:..|.::.      ||.:
Worm   686 MFERFKSEMAAEGKEVKLGGKGFEGSGYKYDEGEAEADANKKRMTRLVHGMEAGGDDDDDLEE-- 748

  Fly   910 NPLLQPGTLIRCKFLKAYDPAHMAVMPMKYKSKDSTIWIDVPYPSYPSTLVFKMSFGVPRKVHNP 974
                |..::|:.|         ..|:..|            |....||:     |.|..:.....
Worm   749 ----QLSSMIKTK---------RRVVHGK------------PQSEKPSS-----SSGNAKNDREA 783

  Fly   975 CKINDVCFVQHKELLSRVRIVDNPARP------QVTVQLMDYGTELLQVKASQLLECPEQFRDLQ 1033
            .|..|...::.:||.:|::......:|      |:|.:.:..|.|:...:.|..:...|:...|.
Worm   784 GKRADQAKLKAEELSTRLKGASQVVQPVEKTAAQLTAEAVLRGAEVAPAQMSAAMLAKEKANRLN 848

  Fly  1034 QLAMDIRLSGLAGSG-----QGGMWSTDSIQWVQDRFADINEEIMQITVDFGVLD-VAYVKEIA 1091
            :     :|:.|.|..     |...|.....:|      |||:...|:.......: |.:|.|:|
Worm   849 E-----KLNYLGGEAAPTQQQEEAWEYFEEEW------DINDFPQQVRYKICSRESVGHVAELA 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SoYb	NP_001245959.1	TUDOR	7..115	CDD:278965
		SrmB	475..877	CDD:223587	82/439 (19%)
		P-loop_NTPase	480..>646	CDD:304359	29/171 (17%)
		TUDOR	927..1043	CDD:278965	21/121 (17%)
ddx-46	NP_001033411.1	SrmB	276..793	CDD:223587	106/588 (18%)
		DEADc	316..514	CDD:238167	44/217 (20%)
		HELICc	534..655	CDD:238034	25/132 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910