DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SoYb and tdrd12

DIOPT Version :9

Sequence 1:	NP_001245959.1	Gene:	SoYb / 34331	FlyBaseID:	FBgn0051755	Length:	1476	Species:	Drosophila melanogaster
Sequence 2:	XP_021326385.1	Gene:	tdrd12 / 100334979	ZFINID:	ZDB-GENE-121214-348	Length:	1150	Species:	Danio rerio

Alignment Length:	1203	Identity:	229/1203 - (19%)
Similarity:	424/1203 - (35%)	Gaps:	297/1203 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 DFKEGGVALIAPHSGSVWSRSAIESLDKQLEDANQLTFQVVHRGKSNRNFGLLKFRSSCQTEDAA 185
            :.|||.|.::...:...|.|:.:||:.:                      |:|..::.|...|..
Zfish    58 ELKEGLVCVVFSVALKSWCRAIVESVLQ----------------------GVLDTQAWCLLVDYG 100

  Fly   186 N-FLIKQDQGRCKETLTMAIPYEDISFEKAEINDMAIDTRPRLRRILELVVLLSENAKESTPTPS 249
            : .::::|..|......:.:|:....|..|.:..|.            |.|.|||:..|..|:.|
Zfish   101 DRIIVREDDVRTPLEKFLLLPFRVRRFRLAAVRPMT------------LQVPLSEDTAELVPSAS 153

  Fly   250 --AIQQKKLDALLQ-----------------SHETYLIPNSVKLLSKVQSISES---SMQTALAN 292
              :...|.|..|||                 |.|.||..|:.|:....:.:::.   .:..|..:
Zfish   154 WDSSATKYLLNLLQVSTLVEAVLCETQDDCSSIELYLTINNTKICVNHELVAKKFACFVSDADGS 218

  Fly   293 RSKQISK--------ELPHKANQSE------------DNRKKEVKYLESENLSECLSKVKLSSYQ 337
            ||...:.        ..||:..:.:            ..||:...:..:|            :.|
Zfish   219 RSTDRAPVSLAWDIYSSPHQLLEMKGCCPLRAPPPDTPTRKQRTDHTHTE------------AEQ 271

  Fly   338 QKNTDSSTLSGP-----------RNLASSSTNSNSNVRKSMT-LF-------KSSGAHLTTSL-- 381
            ||...:..:..|           ||..:.:......:|...| ||       ||.....||.|
Zfish   272 QKAEAAEEIHTPSVGKPQVQKLRRNPGTYTIGRGWRIRAEATDLFTAQIHHSKSQYMKFTTLLQP 336

  Fly   382 -----SVPLTENCTNQSNNRTVVFSMDKMEQIFNDMLGKNPSERSVQKNRSQMPNSNVSTTKRCV 441
                 ||...::...|:::.:      :..:::|.:    .||...:.:..|.|  ::.....|.
Zfish   337 KQIPESVEEKQSSPGQTDDNS------EGSRVYNAI----DSEELKEADLPQEP--SLDDHLACA 389

  Fly   442 EKMHVCRSENMGDRKPSVCLK-------HL-VLAHSPEPVNPVTSYKELPLGNTILNAMDDLNFQ 498
            ..|.....:.:...:.:|..|       |. ||.||...:.|.::....|:.......:....:.
Zfish   390 RLMQFLNPDPLNPDQETVDAKVARCDPGHSGVLVHSAIRIEPCSNLTRAPITEQFRKFLLWRKYS 454

  Fly   499 TPLPTQIYAWPHLVNRGSLVLVNPSGTGRSWSYLP---VICSSVLSSFENVTSNLDTRIAPGPLA 560
            .|...:.|.||.:......|||:.|| ....||:|   :|..:|     :|.|:|..|  .||:|
Zfish   455 GPNVAESYCWPAVARGFDTVLVSHSG-DNPLSYIPPLLMILQTV-----SVVSSLAAR--TGPVA 511

  Fly   561 ILIVDSVENAKKLASHCEFLMKDFNTQNLKVVNTHAHSMM-------DVYMMLLNSCGVLVTTLA 618
            :::....|   |:.:..|.|.....|..|     |..|::       .....:..:|.:||||..
Zfish   512 VILCPGWE---KVQTVLELLEDSKATHGL-----HPTSVLLGVDQDEPKKFKIQKNCQLLVTTPF 568

  Fly   619 HLNNILSNELPLVNPTRLEFIIFDDYD---RKRLDNAELLKEVFQKV---NSIGGLSKQLVLVAQ 677
            .|..:|..:..|.  .||..::.|:.|   .:..|...::.:.||::   .......:|::.|..
Zfish   569 SLLRLLEAQCFLF--LRLCHLVLDEADLLYSQAPDQISIILKHFQQLVCAEERVACPRQIIAVGG 631

  Fly   678 QWHSERFQKLLNRTTKPLILFGDFLEAALYGGLKFNVTLRSSALKARQLLDILAEQDGSKKRTLI 742
            :|.:.....:......|.::.....||||||.:...|.|.....|...||..|..|....::|||
Zfish   632 RWSAGIDGLVREHMIHPTVIITVMEEAALYGRVHQRVQLCLDCDKVSVLLSSLDFQPPKPQKTLI 696

  Fly   743 YCKNQMELEELSAILIEAGLQCV-------------------DISKAQNQSPNRLMLVDDSQVRK 788
            ...:..|.|.:...::...:..:                   |||:.     .:::||..:...|
Zfish   697 ITNSAEETEHVYKAVVNTAVFTLKAHEDATDQFDFIIDQWRKDISQG-----TQVILVTTNDCLK 756

  Fly   789 QLPVRNIQLLIHFSLPESWLRFSRRFHTMADNIRNLFTKPIGRGQDLI----TYILMDENNAKEW 849
            .|.:|:...::|:..|.:...|..|...|::|.|.|  ..:...:|..    :.:|:.|.|.:..
Zfish   757 ALGIRDATCVVHYGFPSTPKLFGSRLFCMSENFRKL--SDMDHSEDWTPGAQSVLLLSEQNVRHV 819

  Fly   850 PRIMKFLQDHGLT--------TQSMPDSEQQLDNTLPYCPYKLSNGNCNRNQCNKRHHFLKTDLP 906
            ..::::|:..|..        ...:..::::.....|.|....|.|.|..:......|.:.|.|.
Zfish   820 CGVLRYLRRTGALLPPELLQFALGIQQAKEEQKTHRPLCCSLKSFGFCRDSTVCPDRHTINTSLD 884

  Fly   907 KIGNPLLQPGTLIRCKFLKAYDPAHMAVMPMKYKS----------KDSTIWIDVPYPSYPSTLVF 961
            :...|                |...:.|:|:..|:          :...::.|:       ....
Zfish   885 QTQLP----------------DSGMIMVLPLFIKTASVYCGRIVRQKEDLYEDL-------ATQM 926

  Fly   962 KMSFGVPRKVHNPCKI----NDVCFVQHKELLSRVRIVDNPARPQ-----VTVQLMDYGTELLQV 1017
            |:.:...|:    |.:    ..:..:|.:....|||:::.|.:.:     ||..|:|.| ...:|
Zfish   927 KLHYASERR----CAVEVLKGALYAIQEENCYHRVRVLEVPEKGEQLFSSVTACLIDEG-RTQEV 986

  Fly  1018 KASQLLECPEQFRDLQQLAMDI---RLSGLAGSGQGGMWSTDSIQWVQDRFADINEEIMQITVDF 1079
            |:.|||:.|.||:||...|::|   |:..:.|...   |:....:.|.   ..|..::.|..|..
Zfish   987 KSHQLLQLPAQFQDLPGQAVEIILCRVQPVDGEVD---WNPKVTRAVS---LKIRGKLHQARVVM 1045

  Fly  1080 GVLDVAYVKEIALIEE-------------------CPTMLTSV----YKTFLRK-----ELLRQG 1116
            .:.:..:|..:..|..                   |...:..|    .|||:.:     |:|..|
Zfish  1046 SLGNTIWVDPMVRIRHHGATNRPRFAGFVRFLFPLCGLQVRMVRVPGLKTFINEYNVHTEILASG 1110

  Fly  1117 FAKIDSTSILELRAI------HEQWKQEMEELR 1143
            |...:...:..|:.:      |....|::.|.|
Zfish  1111 FGVSNPQHVDLLKTVLQRDQNHNMLDQQLSEHR 1143

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SoYb	NP_001245959.1	TUDOR	7..115	CDD:278965
		SrmB	475..877	CDD:223587	90/448 (20%)
		P-loop_NTPase	480..>646	CDD:304359	42/178 (24%)
		TUDOR	927..1043	CDD:278965	31/137 (23%)
tdrd12	XP_021326385.1	TUDOR	9..130	CDD:306940	16/93 (17%)
		SrmB	463..>781	CDD:223587	75/340 (22%)
		TUDOR	912..1010	CDD:306940	26/109 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I5115
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26337
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.960