DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bib and aqp4

DIOPT Version :9

Sequence 1:	NP_001260313.1	Gene:	bib / 34330	FlyBaseID:	FBgn0000180	Length:	737	Species:	Drosophila melanogaster
Sequence 2:	NP_001345242.1	Gene:	aqp4 / 445293	ZFINID:	ZDB-GENE-040724-152	Length:	346	Species:	Danio rerio

Alignment Length:	246	Identity:	93/246 - (37%)
Similarity:	140/246 - (56%)	Gaps:	20/246 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 NNRLSSTLQAPKRSMQAEIRTLEFWRSIISECLASFMYVFIVCGAAAGVGVGASVSSV----LLA 101
            ||.:.:..:.        :.|.||||::..|.||  |.:|::....:.:..||...:.    |:.
Zfish    20 NNSIMAAFKG--------VWTQEFWRAVSGEFLA--MIIFVLLSLGSTINWGAKQENPPPADLVL 74

  Fly   102 TALASGLAMATLTQCFLHISGAHINPAVTLALCVVRSISPIRAAMYITAQCGGGIAGAALLYGVT 166
            .:|..||::|||.|||.||||||||||||:|:...|.:|..:...|:.|||.|.:.|||:|||||
Zfish    75 ISLCFGLSIATLVQCFGHISGAHINPAVTVAMVATRKLSLAKGVFYLLAQCLGAVVGAAILYGVT 139

  Fly   167 VPGYQGNLQAAISHSAALAAWERFGVEFILTFLVVLCYFVSTDPMKK-FMGNSAASIGCAYSACC 230
            ....:|.: ...|.:..::|.....:|.|:||.:|...|.:.||.:. ..|::|.:||.:.....
Zfish   140 PASVRGGM-GVTSVNEEISAGHAIVIELIITFELVFTVFATCDPKRNDLKGSAALAIGLSVCIGH 203

  Fly   231 FVSMPY----LNPARSLGPSFVLNKWDSHWVYWFGPLVGGMASGLVYEYIF 277
            ..::||    :|||||.||:.::.||..|||||.|||:||:.:..||||:|
Zfish   204 LFAIPYTGASMNPARSFGPAVIMVKWQDHWVYWVGPLIGGILAAAVYEYLF 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bib	NP_001260313.1	MIP	58..273	CDD:278651	86/223 (39%)
aqp4	NP_001345242.1	MIP	32..250	CDD:278651	86/220 (39%)
aqp4	NP_001345242.1	DUF737	<290..>345	CDD:310129
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0580
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1152704at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2356
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850