DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bib and AQP6

DIOPT Version :9

Sequence 1:	NP_001260313.1	Gene:	bib / 34330	FlyBaseID:	FBgn0000180	Length:	737	Species:	Drosophila melanogaster
Sequence 2:	NP_001643.2	Gene:	AQP6 / 363	HGNCID:	639	Length:	282	Species:	Homo sapiens

Alignment Length:	258	Identity:	86/258 - (33%)
Similarity:	130/258 - (50%)	Gaps:	47/258 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 GGHGVNNRLSSTLQAPKRSMQAEIRTLEFW----RSIISECLASFMYVFIVCGAAAGVGVGA--- 93
            ||.|..:.|:..|                |    |::.:|.||:.:|||.        |||:
Human     7 GGRGWASMLACRL----------------WKAISRALFAEFLATGLYVFF--------GVGSVMR 47

  Fly    94 ---SVSSVLLATALASGLAMATLTQCFLHISGAHINPAVTLALCVVRSISPIRAAMYITAQCGGG 155
               ::.|| |..|:...|..|...|.....||||.|||||||..|...||..||..|:.||..|.
Human    48 WPTALPSV-LQIAITFNLVTAMAVQVTWKASGAHANPAVTLAFLVGSHISLPRAVAYVAAQLVGA 111

  Fly   156 IAGAALLYGVTVPGYQGNLQAAISHSA---ALAAWERFGVEFILTFLVVLCYFVSTDPMKKFMGN 217
            ..|||||||| :|   |:::..:..:.   :::..:...||.:||..:|||.|.||| .::..|:
Human   112 TVGAALLYGV-MP---GDIRETLGINVVRNSVSTGQAVAVELLLTLQLVLCVFASTD-SRQTSGS 171

  Fly   218 SAASIGCAYSACCFVSMPY----LNPARSLGPSFVLNKWDSHWVYWFGPLVGGMASGLVYEYI 276
            .|..||.:.:....:.:.:    :|||||.||:.::.|:..|||:|.|||:|.:.:.|:|.::
Human   172 PATMIGISVALGHLIGIHFTGCSMNPARSFGPAIIIGKFTVHWVFWVGPLMGALLASLIYNFV 234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bib	NP_001260313.1	MIP	58..273	CDD:278651	80/231 (35%)
AQP6	NP_001643.2	MIP	25..231	CDD:294134	79/219 (36%)
		NPA 1	82..84		1/1 (100%)
		NPA 2	196..198		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..282
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1152704at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920