Protein Alignment bib and AQP4

DIOPT Version :10

• Sequence 1: NP_001260313.1
• Gene: bib / 34330
• FlyBaseID: FBgn0000180
• Length: 737
• Species: Drosophila melanogaster
• Sequence 2: NP_001304313.1
• Gene: AQP4 / 361
• HGNCID: 637
• Length: 352
• Species: Homo sapiens
• Alignment Length: 291
• Identity: 98/291 - (33%)
• Similarity: 153/291 - (52%)
• Gaps: 34/291 - (11%)

  Fly    61 TLEFWRSIISECLASFMYVFIVCGAA---AGVGVGASVSSVLLATALASGLAMATLTQCFLHISG 122
            |..||:::.:|.||..::|.:..|:.   .|......|..||:  :|..||::||:.|||.||||
Human    31 TQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLI--SLCFGLSIATMVQCFGHISG 93

  Fly   123 AHINPAVTLALCVVRSISPIRAAMYITAQCGGGIAGAALLYGVTVPGYQGNLQAAISHSAALAAW 187
            .|||||||:|:...|.||..::..||.|||.|.|.||.:||.||.|...|.|...:.| ..|.|.
Human    94 GHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVH-GNLTAG 157

  Fly   188 ERFGVEFILTFLVVLCYFVSTDPMK-KFMGNSAASIGCAYSACCFVSMPY----LNPARSLGPSF 247
            ....||.|:||.:|...|.|.|..: ...|:.|.:||.:.:.....::.|    :|||||.||:.
Human   158 HGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAV 222

  Fly   248 VLNKWDSHWVYWFGPLVGGMASGLVYEYIF-----------NSRNRNLRHNKGS---IDNDSSSI 298
            ::..|::||:||.||::|.:.:|.:|||:|           .:.::..:..|||   ::::.|.:
Human   223 IMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQV 287

  Fly   299 HSED---------ELNYDMDMEKPNKYQQSQ 320
            .::|         .::.|...||..|.|..:
Human   288 ETDDLILKPGVVHVIDVDRGEEKKGKDQSGE 318

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bib	NP_001260313.1	MIP	58..273	CDD:395174	84/219 (38%)
AQP4	NP_001304313.1	MIP	31..248	CDD:395174	84/219 (38%)