DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dref and ivph-3

DIOPT Version :9

Sequence 1:	NP_001260311.1	Gene:	Dref / 34328	FlyBaseID:	FBgn0015664	Length:	709	Species:	Drosophila melanogaster
Sequence 2:	NP_001368275.1	Gene:	ivph-3 / 177086	WormBaseID:	WBGene00022067	Length:	768	Species:	Caenorhabditis elegans

Alignment Length:	711	Identity:	146/711 - (20%)
Similarity:	249/711 - (35%)	Gaps:	210/711 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 CQEHDIHVPPRKTP-----RNVSHPPLSKRNVSSRRVKLEFINNRNHDNASDDELDEAAVATAAM 150
            ||| .|..|.::..     ..:|.|......:.::|..   |.|....:|:...|...:...|:.
Worm    77 CQE-SIDNPMKRQKLMAFCEQISSPQAPSTKMGNKRSN---IRNLVLAHAARKALRLNSQTDAST 137

  Fly   151 QAEEDASSQT--------MLYETMVPFTYDEAENLVEEEE---------------------RLVM 186
            .|:|.::|.|        .:.|...|...:..:  :|||:                     |...
Worm   138 TADEPSTSGTTGIVEKKETMNERKAPIFVETVK--MEEEKFQDDSAEDEPPPNLAPAPPIPRFAA 200

  Fly   187 EPKYGRKRKVATPSSALMHGRVIKHE---EGGYAAVANIANLAEALTDIVIKDLRNVDSLYDAGF 248
            .|.:.|.|   .||: ..:.||...|   |.||::|.....  |..|..::.:...:.|:.|...
Worm   201 VPVFPRSR---IPST-YPYRRVEPFEHTSEHGYSSVERYNE--EVATRFLLGNGLPLTSIEDHDL 259

  Fly   249 GEFLRQVLGNSAAMPEPHKIDSLINEMHASKFLEIGEITRDFTSEK---PFSLAFEMWVNVEQRR 310
            ..|| ..|..|.::|||       :.|....:   ||.....:.:|   |.::..|. :......
Worm   260 RTFL-TTLNPSRSLPEP-------SNMTTKAY---GEYRPSLSYQKSIGPLNVTIEA-IRKNDEI 312

  Fly   311 FLSIFHHFLDE--ETHSVRGMLYATVEYNDYIVFD-------DLLTDFYLANCTLAIINYDEEED 366
            ||||..|:.|.  |.|:       ||.:...|:.|       |.|.....||.::   |:. ..:
Worm   313 FLSISVHYYDSLGERHN-------TVHFEKIILADYEGKVVADRLRRVIDANKSM---NFG-ISN 366

  Fly   367 LLHTYLR-----EKNIPIS---LCYVSVIDKCLRRVFEIEEVAT---LLEQVKDLMQRH------ 414
            :|...||     .:|:|..   :|:.|.:....|.|.:|.|..:   ||.:....:::|
Worm   367 ILSPNLRMLTLVAENMPFKNRFICFFSYLSNIAREVIQIPEFLSSLKLLREYVGALRKHPEVYTK 431

  Fly   415 --STEIASKVSEVPMPTYNEHFPWTLYETLKFFAESISWSEDMDHL--------VISAKTVTEAL 469
              ...|.||:: ..:|..:....|  ..||:|.:.....:|...:|        .:.|  |.|
Worm   432 FRKMLIESKIT-TDIPALDVESDW--LSTLQFLSTCGLLNETFSNLHENWCMPKYLDA--VQE-- 489

  Fly   470 SALVIALDTLRGEDIPLCSMLSPI------TSKIL---------IKKLGIAEQDDPLMMNLKRTI 519
            :::...||.|    :.||::.:.|      .|::|         |:..||.|..:.:.....:..
Worm   490 NSMAFLLDFL----LVLCNVATQICSEDSSVSQVLYSMSIVNNAIENCGIVEAREKMRSTFSKYY 550

  Fly   520 SSVLQAHVISNDNLTAAALLDPRFHRLTTIDNLERTVRMLTHKYNINFGGVGEGESNEVAATSSV 584
            ||:....:  .|..:.:||||||:                                    ..|.:
Worm   551 SSISNGKI--GDFYSISALLDPRY------------------------------------GYSPM 577

  Fly   585 VAIKSEPRVVDGSAPKKLGLKLLFDSNEIPNPPKRDADSSVESDLKRYRNEVVVQ---LDES--P 644
            :..:.:...|:|...|:  :......|.|           |..:|:||| |::|.   .|||  |
Worm   578 IFSEEDWENVEGKLLKE--MSTTHQKNLI-----------VRKELQRYR-ELLVNRPLFDESNTP 628

  Fly   645 IEWWLKMGHIYGTLRDLASLYHSVPGVVTLSFKKALRDQIYDFNKRFMLTG---SHIDAIL 702
            ..||   ..:...|:.:...:....|:..:|..          .|||...|   :|:.|.|
Worm   629 GMWW---NDLQEELQFMYKKWFEYSGLPAVSID----------GKRFFAKGGKLAHLFATL 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
Dref	NP_001260311.1	zf-BED	35..84	CDD:280965
ivph-3	NP_001368275.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223749at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010