DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dref and LOC105945140

DIOPT Version :9

Sequence 1:	NP_001260311.1	Gene:	Dref / 34328	FlyBaseID:	FBgn0015664	Length:	709	Species:	Drosophila melanogaster
Sequence 2:	XP_012813067.2	Gene:	LOC105945140 / 105945140	-ID:	-	Length:	693	Species:	Xenopus tropicalis

Alignment Length:	781	Identity:	147/781 - (18%)
Similarity:	268/781 - (34%)	Gaps:	252/781 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 PKMKSVYWRYFGFPSNDNNEVITKQNVVCIKCHKVLTNHGNTTNLRAHLQHRHKDLFKELCQEHD 95
            |:.||..|:||||.:|....::..:.:.|..|...:...|||:||..||:..|.|   |.|
Frog    19 PRAKSKVWKYFGFDTNAEGCILQWKKIYCRICMAQIAYSGNTSNLSYHLEKNHPD---EFC---- 76

  Fly    96 IHVPPRKTPRNVSHPPLSKRNVSSRRVKLEFINNRNHDNASDDELDEAAVATAAMQAEEDASSQT 160
                                         ||:.       |:.|....|.|||..:.:.::|.|.
Frog    77 -----------------------------EFVK-------SNTEQMREAFATAFSKLKPESSQQV 105

  Fly   161 MLYETMVPFTYDEAENLVEEEERLVMEPKYGRKRKVATPSSALMHGRVIKHEEGGYAAVANIAN- 224
            :                   :|.|:|:..:..:.|              ||.|...:.::.|..
Frog   106 V-------------------QETLIMKNTHSFENK--------------KHLELTSSVISLICEG 137

  Fly   225 --LAEALTDIVIKD-LRNVDSLYDAGFGEFLRQVLGNSAAMPEPHKIDSLINEMHASKFLEIGEI 286
              .|..|.:...|: |:..:..|:....:::     .|..:||.:   :.|.||          :
Frog   138 MYPASILDEPTFKNLLKTAEPRYEVPMRKYI-----CSRVLPEKY---NAIREM----------V 184

  Fly   287 TRDFTSEKPFSLAFEMWVNVEQRR-FLSIFHHFL----------------------DEETHSVRG 328
            .:|........::.:||.:|.|.| ::::..:|:                      :.:..::..
Frog   185 LKDLNDILWCGISTDMWKSVTQNRSYVTLSVYFMSTGPSNCLSVNSRCLKTFEVPEENKAETITR 249

  Fly   329 MLYAT-VEYNDYIVFDDLLTDF---YLANCTLAIINYDEEEDLLHTYLREKNIPISL-CYVSVID 388
            :||.| :|:..........|||   .:..|:|.                  :||:.: |.....|
Frog   250 VLYETFIEWGISAKVFGATTDFSKDIVKACSLL------------------DIPVDMPCLGQTFD 296

  Fly   389 KCLRRVFEIEEVATLLEQVKDLMQRHSTEIASKVSEVPMPTYNEHFPWTLYETLKFFAESISW-- 451
            ..:::.|::.::::||.:.:.|::.......:.............||..|      .::.:||
Frog   297 MGIQQAFQLPKLSSLLSRCRKLVEYFQQSSIAMYMLCEKQKQQNLFPCML------ISDRVSWWG 355

  Fly   452 --------------------SEDMD--HLVISA----------------KTVTEALSALVIALDT 478
                                .||.:  ||::.|                |.|.|.||.
Frog   356 STLVMLQRLKEQQFTIAGVLVEDSNNHHLMLEASEWNTIEGLVDLLQPFKQVAEMLSV------- 413

  Fly   479 LRGEDIPLCSMLSPITSKILIKKLGIAEQDDPLMMNLKRTISSVLQAHVISNDN----LTAAALL 539
               ...|..||:.|:...:|...|.|.|.|...:...|..|:.||.:.......    |..|..|
Frog   414 ---SKYPTISMVKPLLHMLLNTSLNIKETDPKEISMAKEVIAKVLSSTYQQTPEIDMFLNVATFL 475

  Fly   540 DPRFHRLTTIDNLERTV---RMLTHKYNINFGGVGEGESNEVAATSSVVAIKSEP---RVVDGSA 598
            |||:.:|..:...||..   |::......    :.:|:.| :.....|..|..||   ::...:.
Frog   476 DPRYKKLPFLSAFERAQVENRVIEEAKCF----IDKGKEN-IKNEEKVFTISEEPPMKKMASSTP 535

  Fly   599 PKKLGLKLLFDSNEIPNPPKRDAD---SSVESDLKRYRNEVVVQLDESPIEWWLKMGHIYGTLRD 660
            |....:..:.......:....|.:   :.|..:|..::::.|:.|:|.|::||          .|
Frog   536 PPTSSINSMLAEIFCQSGSSEDQEEWHAQVVEELSNFKSQKVLGLNEDPLKWW----------SD 590

  Fly   661 LASLYHSVPGVV--------TLSFKKALRDQIYDFN--------KRFMLTGSHIDAILFLHH--H 707
            ..:|:..:|.|:        |..|.:.|      ||        ||..|..:|:|..:||:.  |
Frog   591 RLTLFPLLPKVLQKYWCIRPTRVFPERL------FNSSANVVNSKRNRLAPAHVDEQIFLYENTH 649

  Fly   708 N 708
            |
Frog   650 N 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dref	NP_001260311.1	zf-BED	35..84	CDD:280965	16/48 (33%)
LOC105945140	XP_012813067.2	zf-BED	23..72	CDD:397159	16/48 (33%)
		DUF4413	412..514	CDD:405121	26/116 (22%)
		Dimer_Tnp_hAT	568..647	CDD:399013	23/94 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223749at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46169
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020