DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dref and Zbed6

DIOPT Version :9

Sequence 1:	NP_001260311.1	Gene:	Dref / 34328	FlyBaseID:	FBgn0015664	Length:	709	Species:	Drosophila melanogaster
Sequence 2:	XP_038947242.1	Gene:	Zbed6 / 103693666	RGDID:	9238526	Length:	983	Species:	Rattus norvegicus

Alignment Length:	818	Identity:	143/818 - (17%)
Similarity:	268/818 - (32%)	Gaps:	264/818 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PASPVAIGELKYEDVSQLNFSKLYSPKMK--------------------------------SVYW 38
            |:||.:.|..:|.....|:.:::...:.|                                |..|
  Rat   207 PSSPGSNGSFEYIPTDSLDENRMGKKRDKSASDALRAKRGRFLIKSNIVKHALIPGTRAKTSAVW 271

  Fly    39 RYFGFPSNDNNEVITKQNVVCIKCHKVLT-----NHGNTTNLRAHLQHRHKDLFKELCQEHDIHV 98
            .:|   ..|...:   ...||..|.:.::     :|..|:.|:.|||           ..|.||.
  Rat   272 NFF---YTDPQHI---SRAVCNICKRSVSRGRPGSHLGTSTLQRHLQ-----------ATHPIHW 319

  Fly    99 PPRKTPRNVSHPPLSKRNVSSRRVKLEFINNRNH-------------DNASDDELDEAAVATAAM 150
            .............|.:....|.    :.:|:..|             |.:..|:.||..|    :
  Rat   320 AVANKDSGAIGNGLDETETESG----DLLNDTLHGEKSSGSQDLTAEDLSDSDDTDEPPV----L 376

  Fly   151 QAEEDASSQTMLYETMVPFTYDEAENLVEEEERLVMEPKYGRKRKVATPSSALMHGRVIKHEEGG 215
            :.|..:.|         |....|.:||...:|           |:..|.:          |.|.
  Rat   377 EVENRSES---------PIPVAEQDNLAHTQE-----------RETTTDT----------HCED- 410

  Fly   216 YAAVANIANLAEALTDIVIKDLRNVDSLYDAGFGEFLRQVLGNSAAMPE---------PHKIDSL 271
                |..:.:::|:..::::||...:......|..|| |::.....:|.         |...||:
  Rat   411 ----AASSQISQAVIQMIVEDLHPYNYFSTPAFQRFL-QIVAPDYRLPSETYFFTKAVPQLYDSV 470

  Fly   272 INEMHASKFLEIGEITRDFTSEKPFSLAFEMWVNVEQRRFLSIFHHFLDEETHS----------- 325
            ..::.         :|.:....:...|..::|.:.....:..:..|::..||.|
  Rat   471 REKIF---------LTLENVQSQKIHLTVDIWTHDPSTDYFIVTVHWVSLETASSPSNGGTPNFR 526

  Fly   326 ------VRGM----LYATV--EYNDYIVF----DDLLTDFYLANCTLAIINYDEEEDLLHTYLRE 374
                  |.|:    |...:  |.||.|..    :.|:..|.:::.:..:::..:.....|
  Rat   527 KWAVLCVTGLAKDCLITNILQELNDQIGLWLSPNFLIPSFIVSDNSSNVVHAIKGGGFTH----- 586

  Fly   375 KNIPISLCYVSVIDKCLRRVF-EIEEVATLLEQVKDLMQRHSTEIASKVSEVPMPTYNEH-FPW- 436
              :|   |::..::..::..| |.:.:..:|...:......|..:  |..::.....|:| .||
  Rat   587 --VP---CFLHCLNIVIQDFFCEHKSIENMLVAARKTCHHFSHSV--KARQILQEFQNDHQLPWK 644

  Fly   437 ------------TLYETLKFFAESISWSEDMDHLVISAKTVTEALSALVIALDTLRGEDIPLCSM 489
                        |.| .||:..|.   ...:.|.:..|..|  .|::|...|.|.      :|.:
  Rat   645 NLKQDETGHWISTFY-MLKWLLEH---CYSVHHSLGRASGV--VLTSLQWTLMTY------VCDI 697

  Fly   490 LSPI---TSKILIKKLGIAE----------------QD-------------DPLMMNLKRTISSV 522
            |.|.   |.::.:|..|:.:                :|             |.|.:.|:   |..
  Rat   698 LKPFEEATQRVSVKTTGLNQVLPIIHHLLFSLQRLREDFQVRGITQALNLVDSLSLKLE---SDA 759

  Fly   523 LQAHVISNDNLTAAALLDPRFHRLTTIDNLERTVRMLTHK---------YNINFGGVGEGESNEV 578
            |.:.::.:.:...|.||||.| :.:..|...:...:.|:|         |..:..|..:..|:|.
  Rat   760 LLSAMLKSKHCILATLLDPCF-KNSLEDFFPQGADLETYKQILAEEVCNYMESSPGACQIASSEA 823

  Fly   579 A------ATSSVVAIK---SEPRVVDGSAPKKLGL---KLLFDSNEIPNPPKRDADSSVESDLKR 631
            :      .|.|..:||   |....:|.||...:.:   ..||.|          |.:.|:...|.
  Rat   824 SGPLVRLGTDSFTSIKEGTSSAGSMDSSAADSVAIGSRSFLFPS----------AVAVVDEYFKE 878

  Fly   632 YRNEVVVQLDESPIEWWLKMGHIYGTLRDLASLYHSVP 669
            ..:|  :...:.|:.:|.:...|:..|..:|..|.|.|
  Rat   879 KYSE--LSGGDDPLVYWQRKVSIWPALTQVAIQYLSCP 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dref	NP_001260311.1	zf-BED	35..84	CDD:280965	13/53 (25%)
Zbed6	XP_038947242.1	ZnF_BED	135..182	CDD:214746
		ZnF_BED	270..316	CDD:214746	12/62 (19%)
		Dimer_Tnp_hAT	873..953	CDD:399013	10/44 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223749at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010