DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dref and ZBED6

DIOPT Version :9

Sequence 1:	NP_001260311.1	Gene:	Dref / 34328	FlyBaseID:	FBgn0015664	Length:	709	Species:	Drosophila melanogaster
Sequence 2:	NP_001167579.1	Gene:	ZBED6 / 100381270	HGNCID:	33273	Length:	979	Species:	Homo sapiens

Alignment Length:	902	Identity:	159/902 - (17%)
Similarity:	302/902 - (33%)	Gaps:	284/902 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 EDVSQLNFSK-LYSPKMK---SVYWRYFGFPSNDNNEVITKQ---NVVCIKCHKVLT-----NHG 70
            |.:.:.|..| :|.|..:   |:.|.:|.         :..|   ..:|..|.|.::     :|.
Human   112 ESLFESNIEKQIYLPSTRAKTSIVWHFFH---------VDPQYTWRAICNLCEKSVSRGKPGSHL 167

  Fly    71 NTTNLRAHLQHRHK------DLFKELCQEHDIHVPPRKTPRNVSHPPLSKRNVSSRRVKLEFINN 129
            .|:.|:.|||.||.      :.|.....|.|..:       :||..|.|..|.|...:..:.:::
Human   168 GTSTLQRHLQARHSPHWTRANKFGVASGEEDFTL-------DVSLSPSSGSNGSFEYIPTDPLDD 225

  Fly   130 ----RNHDNASDDEL-------------------------------------------------- 140
                :.||.::.|.|
Human   226 NRMGKKHDKSASDALRAERGRFLIKSNIVKHALIPGTRAKTSAVWNFFYTDPQHISRAVCNICKR 290

  Fly   141 ---------------------------------DEAAVATAAMQAEEDAS---SQTMLYETMVPF 169
                                             |..|||....:||.:.|   |.|:..|.....
Human   291 SVSRGRPGSHLGTSTLQRHLQATHPIHWAVANKDSGAVANGLDEAETERSDLLSDTLHGEKSTGS 355

  Fly   170 TYDEAENLVEEEERLVMEPKYGRKRKVATPSSALMHGRVIKHEEGGYAAVAN--IANLAEALTDI 232
            ....||:|.:.:..   ||....:.:..:|......|.:::.:|.......|  .:::::|:..:
Human   356 QDLTAEDLSDSDSD---EPMLEVENRSESPIPVAEQGTLMRAQERETTCCGNPVSSHISQAIIQM 417

  Fly   233 VIKDLRNVDSLYDAGFGEFLRQVLGNSAAMPE-----PHKIDSLINEMHASKFLEIGEITRDFTS 292
            :::|:...:......|..|: |::.....:|.     ...:..|.:.:....||.:..:    .|
Human   418 IVEDMHPYNYFSTPAFQRFM-QIVAPDYRLPSETYFFTKAVPQLYDCVREKIFLTLENV----QS 477

  Fly   293 EKPFSLAFEMWVNVEQRRFLSIFHHFLDEETHS-----------------VRGM----LYATV-- 334
            :| ..|..::|.:.....:..:..|::..||.|                 |.|:    |...:
Human   478 QK-IHLTVDIWTHDPSTDYFIVTVHWVSLETASFLNNGRIPDFRKWAVLCVTGLAKDCLITNILQ 541

  Fly   335 EYNDYIVF----DDLLTDFYLANCTLAIINYDEEEDLLHTYLREKNIPISLCYVSVIDKCLRRVF 395
            |.||.|..    :.|:..|.:::.:..:::..::....|       :|   |::..::..::..|
Human   542 ELNDQIGLWLSPNFLIPSFIVSDNSSNVVHAIKDGGFTH-------VP---CFLHCLNMVIQDFF 596

  Fly   396 -EIEEVATLLEQVKDLMQRHSTEIASKVSEVPMPTYNEH-FPW-------------TLYETLKFF 445
             |.:.:..:|...:......|..:  |..::.....|:| .||             |.| .||:.
Human   597 CEHKSIENMLVAARKTCHHFSHSV--KARQILQEFQNDHQLPWKNLKQDETGHWISTFY-MLKWL 658

  Fly   446 AESISWSEDMDHLVISAKTVTEALSALVIALDTLRGEDIPLCSMLSPI---TSKILIKKLGIAEQ 507
            .|.   ...:.|.:..|..|  .|::|...|.|.      :|.:|.|.   |.|:.:|..|: .|
Human   659 LEH---CYSVHHSLGRASGV--VLTSLQWTLMTY------VCDILKPFEEATQKVSVKTAGL-NQ 711

  Fly   508 DDPLM----------------------MNLKRTISSVLQAHVISNDNLTA-----AALLDPRFHR 545
            ..||:                      :||..::|..|:...:.:..|.:     |.||||.| :
Human   712 VLPLIHHLLLSLQKLREDFQVRGITQALNLVDSLSLKLETDTLLSAMLKSKPCILATLLDPCF-K 775

  Fly   546 LTTIDNLERTVRMLTHK---------YNINFGGVGEGESNEVAA----------TSSVVAIKSEP 591
            .:..|...:...:.|:|         |..:...:.:..::|.:.          |||:....|..
Human   776 NSLEDFFPQGADLETYKQFLAEEVCNYMESSPEICQIPTSEASCPSVTVGADSFTSSLKEGTSSS 840

  Fly   592 RVVDGSAPKKLGL---KLLFDSNEIPNPPKRDADSSVESDLKRYRNEVVVQLDESPIEWWLKMGH 653
            ..||.||...:.|   ..:|.|          |.:.|:...|...:|  ....:.|:.:|.:...
Human   841 GSVDSSAVDNVALGSKSFMFPS----------AVAVVDEYFKEKYSE--FSGGDDPLIYWQRKIS 893

  Fly   654 IYGTLRDLASLYHSVPGVVTLSFKKALRDQIYDFNKRF------MLTGSHIDAILFL 704
            |:..|..:|..|.|.|   ..|::.   :.|:..|..|      .|...:|:.::||
Human   894 IWPALTQVAIQYLSCP---MCSWQS---ECIFTKNSHFHPKQIMSLDFDNIEQLMFL 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dref	NP_001260311.1	zf-BED	35..84	CDD:280965	14/56 (25%)
ZBED6	NP_001167579.1	Required for nucleolar localization. /evidence=ECO:0000250\|UniProtKB:D2EAC2	1..89
		ZnF_BED	135..182	CDD:214746	14/55 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	207..232		4/24 (17%)
		ZnF_BED	269..315	CDD:214746	0/45 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	333..383		11/52 (21%)
		HATC (Hobo-Ac-Tam3) domain	866..948		19/87 (22%)
		Dimer_Tnp_hAT	868..948	CDD:283379	18/85 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1121
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223749at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820