DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dref and zbed4

DIOPT Version :9

Sequence 1:	NP_001260311.1	Gene:	Dref / 34328	FlyBaseID:	FBgn0015664	Length:	709	Species:	Drosophila melanogaster
Sequence 2:	NP_001076410.1	Gene:	zbed4 / 100000808	ZFINID:	ZDB-GENE-041210-305	Length:	1249	Species:	Danio rerio

Alignment Length:	715	Identity:	135/715 - (18%)
Similarity:	243/715 - (33%)	Gaps:	219/715 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 KMKSVYWRYFGFPSNDNNEVITKQNVVCIKCHKVLTNHGNTTNLRAHLQHRHKDLFKELCQEHDI 96
            |..|..|.:|...|.|..:      |||:.|.:.::....||||......||...|.....|::.
Zfish   631 KKTSKLWNHFSISSADPTK------VVCLHCSRTISRGKKTTNLGTSCLFRHMQRFHGHVLENNS 689

  Fly    97 HV----PPRKTPRNVSHPPLSKRNVSSRRVKLEFIN-NRNHDNASD-DELDEAAVATAAMQAEED 155
            ::    |..:|                 :||.|.:: :...:||.. .|...||.....:.||
Zfish   690 NISGDGPSAET-----------------QVKQELMDISTYQENAEKFSECHPAAKKITKLIAE-- 735

  Fly   156 ASSQTMLYETMVPFTYDEAENLVEEEERLV--MEPKYGRKRKVATPSSALMHGRVIKHEEGGYAA 218
                 ||...:.|.|..|...|    .||:  ::|:|.     ..|||              |..
Zfish   736 -----MLALDLQPSTVVENVGL----NRLLEYLQPQYS-----LPPSS--------------YFT 772

  Fly   219 VANIANLAEALTDIVIKDLRNVDSLYDAGFGEFLRQV-LGN----------------SAAMPEPH 266
            ...|..:.|::.::|:..|:..    :.|...|...| :|:                |..:|:.
Zfish   773 STAIPEMYESVKEVVLTHLKEA----EGGIIHFTTSVWIGSQTQEYLILTAHWVSFESQVLPQG- 832

  Fly   267 KIDSLINEMHASKFLEIGEITRDFTS---EKPFSLAFEMWVNVEQRRFLSIFHHFLDEETHSVRG 328
                  .:.|.|..|.:..|..|:..   :|.....::.|:....   |.|.....|.:|  :|.
Zfish   833 ------QDFHCSALLGVASIDCDYNMLNIQKQLEYLWDTWMGSSG---LKIGFTVTDNQT--IRN 886

  Fly   329 MLYATVEYNDYIVFDDLLTDFYLANCTLAIINYDEEEDLLHTYLREKNIPISLCYVSVIDKCLRR 393
            :|                                  |...||.::        |:|..||..:..
Zfish   887 VL----------------------------------ESCDHTTMQ--------CFVHNIDLIVNE 909

  Fly   394 VFEIEE-VATLLEQVKDLMQR-HSTEIA-------SKVSEVPMPTYNEHFPWTLYETLKFFAES- 448
            ..:.:. |..||...:.:.:| |.:..|       .||.::|.....:..| :.::|..|..|.
Zfish   910 AIKSQRMVQNLLSIARKICERVHRSAKAKEKLAELQKVYQLPENQLVQDVP-SKWKTSYFMLERL 973

  Fly   449 ISWSEDMDHLVISAK--------------TVTEALSALVIALDTLR------GEDIPLCSMLSPI 493
            :...:.:|.:.|...              :|..||...|:|...:.      |:.|||..:|:..
Zfish   974 VEQKKAIDEMSIECNFRELISCDQWEVMGSVCNALKPFVVACREMSNRTATLGQVIPLIHILNRK 1038

  Fly   494 TSKILIKKLGIAEQDDPLMMNLKRTISSVLQAHVISNDNLTAAALLDPRFH-RLTTIDNLERTVR 557
            ...:..:.:||    |.::.:||..:.:.: :..:.:.....|.:||||:. .|.|.:..|:...
Zfish  1039 IDMLFDETMGI----DNMLKSLKEALVTRM-SPTLHDPRYIWATMLDPRYKTSLFTEEEAEQCKH 1098

  Fly   558 MLTHKYNINFGGVGEGES------NEVAATSSVVAIKSE----------PRVVDGSAPKKLGLKL 606
            .|..:..::.....|.::      :|:.|:|:.:|...|          .::.....||.|.|.:
Zfish  1099 DLIQELEVSTSNSAETKTPLSNGCSEIPASSNSLASNKENLWSLMDDIRQKIKQEEKPKSLELAV 1163

  Fly   607 LFDSNEIPNPPKRDADSSVESDLKRYRNEVVVQLDES--PIEWWLKMGHIYGTLRDLASLYHSVP 669
            |               ..:|.|:          ||:|  |:::|.....::..|..:|..|...|
Zfish  1164 L---------------EYLEEDI----------LDQSCDPLDYWNLKKLLWPDLAKVAVRYVGCP 1203

Fly 670 669
Zfish 1204 1203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dref	NP_001260311.1	zf-BED	35..84	CDD:280965	14/48 (29%)
zbed4	NP_001076410.1	zf-BED	205..253	CDD:280965
		zf-BED	368..414	CDD:280965
		ZnF_BED	538..586	CDD:214746
		zf-BED	634..681	CDD:280965	15/52 (29%)
		Dimer_Tnp_hAT	1165..1242	CDD:283379	11/49 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1121
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D223749at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820