DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5850 and TMEM184C

DIOPT Version :9

Sequence 1:	NP_001260310.1	Gene:	CG5850 / 34327	FlyBaseID:	FBgn0032172	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_060711.2	Gene:	TMEM184C / 55751	HGNCID:	25587	Length:	438	Species:	Homo sapiens

Alignment Length:	407	Identity:	181/407 - (44%)
Similarity:	257/407 - (63%)	Gaps:	41/407 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FEEWRIWIRPLLIITYVIFAIIVVPLLIVNSVKDGFQRNDQLILIGGLFVLSAVPVSIWHIIQHV 74
            :..||.|||||:.:.|::..::.|||.:....|.....:.:...|.|:|:|..:|:|:|.|:||:
Human     7 WRNWRQWIRPLVAVIYLVSIVVAVPLCVWELQKLEVGIHTKAWFIAGIFLLLTIPISLWVILQHL 71

  Fly    75 IHFTKPILQKHIIRILWMVPIYALNAWIGLFFPKHSIYVDSLRECYEAYVIYNFMVYLLNYL--- 136
            :|:|:|.|||.|||||||||||:|::||.|.:|..:||||:.|||||||||||||.:|.|||
Human    72 VHYTQPELQKPIIRILWMVPIYSLDSWIALKYPGIAIYVDTCRECYEAYVIYNFMGFLTNYLTNR 136

  Fly   137 --NLGMDLEATMEYKPQVPHFFPLCCMRPWVMGREFIHNCKHGILQYTVVRPITTFISVICELCG 199
              ||.:.|||    |.|..||.||||..||.||...:..||.|:||||||||.||.:::||||.|
Human   137 YPNLVLILEA----KDQQKHFPPLCCCPPWAMGEVLLFRCKLGVLQYTVVRPFTTIVALICELLG 197

  Fly   200 VYGEGEFAGNVAFPYIVVVNNISQFVAMYCLVLFYRANKEDLKPMKPIPKFLCIKAVVFFSFFQG 264
            :|.||.|:.:.|:.|:|::||:||..|||||:|||:..||:|.|::|:.||||:|.|||.||:|.
Human   198 IYDEGNFSFSNAWTYLVIINNMSQLFAMYCLLLFYKVLKEELSPIQPVGKFLCVKLVVFVSFWQA 262

  Fly   265 VLLNVLVYYNIIKDIFGSDVGDTN-LASLLQNFLICIEMFIAAVAHIYSFPHHPFHINSPQYWNN 328
            |::.:||...:|.:....:..... :|:.||:|:||||||:||:||.|:|.:.|       |...
Human   263 VVIALLVKVGVISEKHTWEWQTVEAVATGLQDFIICIEMFLAAIAHHYTFSYKP-------YVQE 320

  Fly   329 PNHSWC-RAFLSMMDISDMQEDVTEHLGVVGSSLSRRFQGRSTYQPLARSPRRSSSESEYLISKR 392
            .....| .:||:|.|:||:::|::|.:..||    |..:|.         ||:.      |..:.
Human   321 AEEGSCFDSFLAMWDVSDIRDDISEQVRHVG----RTVRGH---------PRKK------LFPED 366

  Fly   393 QDQ----QLPGNSSQSA 405
            |||    .|..:|||.|
Human   367 QDQNEHTSLLSSSSQDA 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5850	NP_001260310.1	Solute_trans_a	51..317	CDD:281602	143/271 (53%)
TMEM184C	NP_060711.2	Solute_trans_a	50..316	CDD:308940	143/269 (53%)
TMEM184C	NP_060711.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..438		12/44 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149795
Domainoid	1	1.000	302	1.000	Domainoid score	I1405
eggNOG	1	0.900	-	-		E1_KOG2641
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32403
Inparanoid	1	1.050	339	1.000	Inparanoid score	I2379
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D411703at33208
OrthoFinder	1	1.000	-	-		FOG0000529
OrthoInspector	1	1.000	-	-		oto89353
orthoMCL	1	0.900	-	-		OOG6_100407
Panther	1	1.100	-	-	LDO	PTHR23423
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1529
SonicParanoid	1	1.000	-	-		X5983
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790