DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5850 and TMEM184B

DIOPT Version :9

Sequence 1:	NP_001260310.1	Gene:	CG5850 / 34327	FlyBaseID:	FBgn0032172	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	XP_016884243.1	Gene:	TMEM184B / 25829	HGNCID:	1310	Length:	452	Species:	Homo sapiens

Alignment Length:	380	Identity:	113/380 - (29%)
Similarity:	191/380 - (50%)	Gaps:	55/380 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 IGGLFVLSAVPVSIWHIIQHVIHFTKPILQKHIIRILWMVPIYALNAWIGLFF---PKHSIYVDS 115
            |.|.||.:|:.::...|..|:..::.|..|::|:|||::|||||.::|:.|.|   .::.:|..:
Human    82 ISGFFVWTALLITCHQIYMHLRCYSCPNEQRYIVRILFIVPIYAFDSWLSLLFFTNDQYYVYFGT 146

  Fly   116 LRECYEAYVIYNFMVYLLNYLNLGMDLEATMEYKP-QVPHFFPLCCM--RPWVMGREFIHNCKHG 177
            :|:||||.|||||:.....||.....:.:.:..|| :....:..||:  :.:.:|  |:..||..
Human   147 VRDCYEALVIYNFLSLCYEYLGGESSIMSEIRGKPIESSCMYGTCCLWGKTYSIG--FLRFCKQA 209

  Fly   178 ILQYTVVRPITTFISVICELCGVYGEGEFAGNVAFPYIVVVNNISQFVAMYCLVLFYRANKEDLK 242
            .||:.||:|:....:|:.:..|.|.:|:|.....:.|:.::.|||..:|:|.|.|||.|.:|.|.
Human   210 TLQFCVVKPLMAVSTVVLQAFGKYRDGDFDVTSGYLYVTIIYNISVSLALYALFLFYFATRELLS 274

  Fly   243 PMKPIPKFLCIKAVVFFSFFQGVLLNVLVYYNIIKDIFGS--DVGDTNLASLLQNFLICIEMFIA 305
            |..|:.||..:|:|:|.||:||:||.:|.....|..|..:  .||:..:|:..|:|:||:|||.|
Human   275 PYSPVLKFFMVKSVIFLSFWQGMLLAILEKCGAIPKIHSARVSVGEGTVAAGYQDFIICVEMFFA 339

  Fly   306 AVAHIYSFPHHPF-------HINSP---------------------QYWNNPN-------HSWCR 335
            |:|..::|.:..:       ..:||                     :...||:       |::..
Human   340 ALALRHAFTYKVYADKRLDAQASSPAPPAPCPAGRCAPMKSISSSLKETMNPHDIVQDAIHNFSP 404

  Fly   336 AFLSMMDISDMQEDVTEHLGVVGSSLSRRFQGRSTYQPLARSPRRS---SSESEY 387
            |:......|.::...|...|..|.|.|....|       ||...::   ||:.|:
Human   405 AYQQYTQQSTLEPGPTWRGGAHGLSRSHSLSG-------ARDNEKTLLLSSDDEF 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5850	NP_001260310.1	Solute_trans_a	51..317	CDD:281602	95/270 (35%)
TMEM184B	XP_016884243.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D411703at33208
OrthoFinder	1	1.000	-	-		FOG0000529
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100407
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1529
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750