DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG5850 and TMEM184A

DIOPT Version :10

Sequence 1:NP_001260310.1 Gene:CG5850 / 34327 FlyBaseID:FBgn0032172 Length:608 Species:Drosophila melanogaster
Sequence 2:NP_001091089.1 Gene:TMEM184A / 202915 HGNCID:28797 Length:413 Species:Homo sapiens


Alignment Length:413 Identity:119/413 - (28%)
Similarity:194/413 - (46%) Gaps:81/413 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 IGGLFVLSAVPVSIWHIIQHVIHFTKPILQKHIIRILWMVPIYALNAWIGLFF---PKHSIYVDS 115
            :.|:||.:|:.::...|..|:..:|.|..|::|||:|.:|||||.::|:.|..   .::.:|.||
Human    58 VSGIFVWTALVLTCHQIYLHLRSYTVPQEQRYIIRLLLIVPIYAFDSWLSLLLLGDHQYYVYFDS 122

  Fly   116 LRECYEAYVIYNFMVYLLNYLNLGMDLEATMEYKP-QVPHFFPLCCMRPWVMGREFIHNCKHGIL 179
            :|:||||:|||:|:.....||.....:.|.:..|| :....:..||:|.......|:..||...|
Human   123 VRDCYEAFVIYSFLSLCFQYLGGEGAIMAEIRGKPIKSSCLYGTCCLRGMTYSIGFLRFCKQATL 187

  Fly   180 QYTVVRPITTFISVICELCGVYGEGEFAGNVAFPYIVVVNNISQFVAMYCLVLFYRANKEDLKPM 244
            |:.:|:|:....::|.:..|.|.:|:|.....:.|:.::.|.|..:|:|.|.|||...:|.|:|.
Human   188 QFCLVKPVMAVTTIILQAFGKYHDGDFNVRSGYLYVTLIYNASVSLALYALFLFYFTTRELLRPF 252

  Fly   245 KPIPKFLCIKAVVFFSFFQGVLLNVLVYYNIIKDI---FGSDVGDTNLASLLQNFLICIEMFIAA 306
            :|:.|||.||||:|.||:||:||.:|....:|.::   .|:.:|...||:..|||:||:||..|:
Human   253 QPVLKFLTIKAVIFLSFWQGLLLAILERCGVIPEVETSGGNKLGAGTLAAGYQNFIICVEMLFAS 317

  Fly   307 VAHIYSFPHHPFHINSPQYWNNPNHSWCRAFLSMMDISDMQEDVTEHLGVVGSSLSRRFQGRSTY 371
            ||..|:||                   |:.:....:.|                           
Human   318 VALRYAFP-------------------CQVYAEKKENS--------------------------- 336

  Fly   372 QPLARSPRRSSSESEYLISKRQDQQLPGNSSQSAGVADDGNSSNSNYQQQQLHLPGAAGSQPSTR 436
             |...:|.:|.|      |..::...|.:..|.|  ..:.:.:..:|.||..|.....|:.||  
Human   337 -PAPPAPMQSIS------SGIRETVSPQDIVQDA--IHNFSPAYQHYTQQATHEAPRPGTHPS-- 390

  Fly   437 QRDTLHLRERERDPGAGAGGGGS 459
                             .|.|||
Human   391 -----------------GGSGGS 396

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5850NP_001260310.1 Solute_trans_a 51..318 CDD:460991 98/270 (36%)
TMEM184ANP_001091089.1 Solute_trans_a 55..329 CDD:460991 99/289 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 372..413 11/44 (25%)

Return to query results.
Submit another query.